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All Journal Pharmacon Jurnal Kesehatan Farmasi
Dwi Saryanti
Program Studi DIII Farmasi, Sekolah Tinggi Ilmu Kesehatan Nasional
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formulasi Tablet Ekstrak Daun Kelengkeng (Euphoria Longana Lam) dengan Variasi Polivinil Pirolidone (PVP K-30) Sebagai Bahan Pengikat Dwi Saryanti; Fatma Eka Saputri
Jurnal Kesehatan Farmasi Vol 4, No 1 (2022)
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.852 KB) | DOI: 10.36086/jpharm.v4i1.1231

Abstract

Background: Longan leaf (Euphoria longana Lam) is one of the plants that can be used by the community as an antipyretic or fever reducer with phytochemical content of saponins, flavonoids, triterpenoids and steroids, tannins, and glycosides. The tablet preparation was chosen in the formulation because it has an accurate dosage per tablet or per unit of use. This study aims to determine the concentration of PVP K-30 can produce tablet preparations from longan leaf extract as a binder that has good physical stability.Methods: Longan leaf extract was obtained by extraction by maceration method using 96% ethanol as solvent. Tablet preparations were made with ethanol extract of longan leaves with varying concentrations of PVP K-30 2%,3%, and 4%. The granule physical stability test includes: water content test, angle of repose test, flow time test, and determination test. The results of the physical stability test of the granules all met the requirements. The tablet physical stability test was carried out on days 0, 7, 14, 21 including: organoleptic test (shape, color, smell, and taste), weight uniformity test, size uniformity test, hardness test, friability test and disintegration time test. Results: The best concentration of PVP K-30 as a binder in longan leaf extract tablets (Euphoria longana Lam) was formula I with a concentration of 2% PVP K-30 binder with a weight uniformity test value (1.611±0.056) size uniformity test ( 1.036±0.046) friability test (0.545±0.090) hardness test (5.494±0.080) disintegration time test (10:22±0.055). Conclusion: Higher levels of PVP K-30 increase hardness, reduce friability and increase tablet disintegration time
Formulasi Gel Antibakteri Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Menggunakan Hydroxy Propyl Methyl Cellulose(HPMC) dan Uji Aktivitas terhadap Staphylococcus aureus Febriana Eka Valentina; Dwi Saryanti
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 1 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i1.18328

Abstract

The content of flavonoids, alkaloids, and saponins in fragrant pandan leaves (Pandanus amaryllifolius Roxb.) can be antibacterial to inhibit the growth of microorganisms on the skin. The extract obtained from fragrant pandan leaves (DPW) is processed into a gel, with the consideration that the gel adheres well, does not block skin pores, is easily rinsed with water and has very good absorption. The purpose of this study was to determine the HPMC content as a gelling agent so as to obtain an antibacterial gel preparation of DPW extract with the best physical quality and antibacterial activity on Staphylococcus aureus (SA). The  DPW ethanol 96% extract gel made from 2%, 3%, 4% HPMC was tested for the physical stability of the gel stored at room temperature for 21 days which included evaluation of organoleptic, homogeneity, degree of acidity, viscosity, spreadability, adhesion. Gel activity against SA was carried out using the well method. Antibacterial gel from DPW extract using 2% HPMC concentration has the best physical quality compared to DPW extract gel with other HPMC concentrations. Antibacterial gel from DPW extract with 2% HPMC concentration in gel form, dark green color, pandan aroma, homogeneous and uniform, pH 6 ± 0, pH is not harmful to skin, viscosity 325 ± 0 dPa.s, spreadability 7.5 gcm /s , adhesion 15.17 ± 0.00 seconds, antibacterial activity against SA with an inhibition zone of 27.26 ± 25.30 mm was classified as very strong. The result of preparations were stable for 21 days.
Co-Authors Fatma Eka Saputri Febriana Eka Valentina