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All Journal Indonesian Journal of Chemical Science Unesa Journal of Chemistry

Mirwa Adiprahara Anggarani

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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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KANDUNGAN SENYAWA BIOAKTIF DAN AKTIVITAS ANTIOKSIDAN BAWANG MERAH NGANJUK (Allium Cepa L.) Shela Insanul Hikmah; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Nganjuk, East Java is a shallot producing area, but its potential as a medicinal and cosmetic plant has not been developed much, especially in the use of its bioactive compounds. The content of bioactive compounds is considered to be potential as antioxidants. This study aimed to determine bioactive compounds and antioxidant activity. Extraction of the samples used a multilevel maceration method with three types of solvents according to polarity, namely ethanol (polar), ethyl acetate (semi-polar), and dichloromethane (non-polar). The type of sample testing carried out is the measurement of bioactive compounds analysis and determination of antioxidant activity using the DPPH method. Flavonoid levels used the AlCl3 method and for the determination of phenolic levels using the Folin Ciocalteu method. The results showed that Nganjuk shallot extract contained bioactive compounds of alkaloids, flavonoids, phenolics, saponins, tannins, triterpenoids, and quinones. The total flavonoid and phenolic levels were weak, namely 0,881% respectively, and 0,966%. Antioxidant activity is shown at the IC50 values of in the ethanol, ethyl acetate, and dichloromethane extracts were 384,0341 ppm; 5336,7889 ppm; 884,2754 ppm. These results indicate that the antioxidant activity of Nganjuk activity is very weak because the value of IC50 > 200 ppm. Key words: nganjuk shallot, bioactive compounds, antioxidant activity

ANALISIS SENYAWA BIOAKTIF DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG PUTIH (Allium Sativum L.) PROBOLINGGO Lailatul Wakhidah; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Garlic is a plant from the Allium genus which is found in the mountainous area of Probolinggo. The potensial bioactive content of this local product has not been studied to be developed in the development of garlic product diversification. This study aims to see the bioactive components, phenol content, flavonoid levels, and antioxidant activity in Probolinggo garlic tubers. The method in this research is divided into two parts, namely the extraction process and sample testing. The extraction process uses a multilevel method with three kinds of solvents, namely dichloromethane (non polar), ethyl acetate (semi polar), and ethanol (polar). The sample tests carried out included analysis of bioactive compounds, phenol levels using the Folin Ciocalteu method, flavonoid levels using the AlCl3 method, and antioxidant activity using the DPPH method. The results of the research on Probolinggo garlic tuber extract with dichloromethane and ethyl acetate solvents containing bioactive steroids and triterpenoids, while ethanol solvent contains bioactive compounds of flavonoids, saponins, steroids, triterpenoids and phenolics. Garlic tuber extract with ethanol solvent has a total phenolic value of 28,756 mg GAE / g and total flavonoids of 21,601 mg QE / g. The IC50 values in the extracts of dichloromethane, ethyl acetate, and ethanol were 421.9643 µg / mL, 310.5998 µg / mL, 257.7503 µg / mL, respectively. In terms of the components of flavonoids, saponins, steroids, triterpenoids and phenolic, garlic tuber extract has a very weak antioxidant activity value. Keywords : garlic tubers, bioactive compounds, antioxidant activity.

PENENTUAN TOTAL FENOLIK, TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN BAWANG KUCAI (Allium tuberosum) Jihan Shofwatul Islam Dalilah Aziz; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The purpose of this research was to determine total phenolic, total flavonoid and antioxidant activity of chinese leeks extract. The extraction process involves a method of leveling using three different types of solvents are dichloromethane, ethyl acetate and ethanol 96%. The samples tested included analysis of total phenolic using Folin-Ciocalteau method, total flavonoid using colorimetric aluminum chloride method and antioxidant activity using DPPH method. The results showed that dichloromethane extract was not found phenolic and flavonoid compounds that are potential as antioxidants. Total phenolic content in ethyl acetate and ethanol extract were 9.5975 mg GAE/g extract and 11.8015 mg GAE/g extract. Total flavonoid content were 4,3454 mg QE/g extract and 7,7165 mg QE/g extract. The value of IC50 on ethyl acetate extract were 563,1250 ppm and and ethanol extract 312,5532 ppm, which are categorized as weak antioxidant. Keywords: chinese leeks, total phenolic, total flavonoid, antioxidant activities

PENENTUAN FENOLIK TOTAL, FLAVONOID TOTAL, DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG LANANG (Allium sativum L.) Dhini Tri Wilujeng; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Free radicals are unstable molecules that can cause oxidative stress. Oxidative stress can lead to damage to cells, tissues, and organs, which can lead to degenerative diseases. Oxidative stress can be reduced by increasing the body's immunity through antioxidants, where these antioxidants can be found in one of the natural ingredients, namely single bulb garlic. The purpose of this study was to determine the potential of imported single bulb garlic with various solvents as a source of natural antioxidants based on total phenolic levels, flavonoids, and antioxidant activity. The Follin-ciocalteu method was used to determine total phenol, total flavonoids were determined colorimetrically with AlCl3, and antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picryhydrazyl) method. The results showed that the total phenolic extract of ethanol 96%, ethyl acetate, and dichloromethane were 13.77 (medium); 26.60 (medium); and 6.36 (low) mg GAE/gr extract. The total flavonoids of ethanol 96% extract, ethyl acetate, and dichloromethane were 0.97; 2.88; and 0.47 mgQE / gr extract. Meanwhile, the antioxidant activity (IC50 value) for 96% ethanol extract was 339.69 ppm (weak), 174.03 ppm for ethyl acetate extract (medium), and 430.48 ppm for dichloromethane extract (weak). Based on the research results, it can be concluded that imported single bulb garlic with the three solvents have potential as a source of natural antioxidants, but the test results are no better than total phenolic, total flavonoids, and antioxidant activity of local single bulb garlic. Key words: Total Phenolic, flavonoid, antioxidant, single bulb garlic

ANALISIS KADAR FENOLIK, FLAVONOID DAN AKTIVITAS ANTIOKSIDAN UMBI BAWANG BOMBAI (Allium cepa L.) Mirwa Adiprahara Anggarani; Rizki Amalia
Unesa Journal of Chemistry Vol 11 No 1 (2022)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Onions are included in the Alliaceae that is often used as a spice in cooking. Onions have potential as a natural antioxidants. The active compounds that act as antioxidants in onions are phenolic and flavonoid contents. The study aimed to determine the water content, ash content, secondary metabolite compounds, total phenolic contents, total flavonoid contents, and antioxidant activity of the onion bulbs (Allium cepa L.). The extraction method chosen was the multilevel maceration method using three different solvents according to their polarity. The solvents are dichloromethane, ethyl acetate, and 96% ethanol. The total extract obtained from dichloromethane, ethyl acetate, and 96% ethanol solvent was 3,661; 1,476; 72,612. The results showed that onions bulb had a moisture content of 64.7% in the wet form and 5.2% in the powder form. The ash content obtained was 5.64%. Phytochemical screening of onion bulb extracts revealed the presence of flavonoids, saponins, tannins, phenolics, quinones, steroids and triterpenoids. The total phenolic and total flavonoid contents of the onion bulb ethanol extract were 18,245 mg GAE/g extract and 3,381 mg QE/g extract. The IC50 value of the onion bulb ethanol extract is 78.723 μg/mL, which includes in the strong antioxidant group. Key words: onion bulb, total phenolic contents, total flavonoid contents, antioxidant activities

Literature Review of Antioxidant Activity of Several Types of Onions and Its Potensial as Health Supplements Mufidatul Ilmiah; Mirwa Adiprahara Anggarani; Dzikra Nasyaya Mahfudhah
Indonesian Journal of Chemical Science Vol 12 No 1 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v12i1.57689

Radikal bebas merupakan suatu atom atau molekul yang memiliki elektron tidak berpasangan yang akan menyebabkan suatu senyawa atau molekul lain menjadi lebih reaktif. Radikal bebas yang terdapat pada tubuh makhluk hidup akan menimbulkan penyakit generatif yakni kerusakan sel. Radikal bebas dapat dinetralkan menggunakan sumber anti oksidan misalnya bawang-bawangan karena mengandung senyawa aktif berupa flavonoid. Kandungan flavonoid didalam bawang-bawangan berpotensi sebagai suplemen Kesehatan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari beberapa jenis bawang dan potensinya sebagai suplemen kesehatan. Metode yang digunakan dalam artikel ini yakni studi literatur dari berbagai sumber ilmiah, baik nasional maupun internasional. Diperoleh data aktivitas antioksidan pada beberapa jenis bawang yang diekstraksi yang menggunakan pelarut etanol. Aktivitas antioksidan yang ditunjukkan dengan nilai IC50 bawang putih probolinggo, bawang dayak, bawang merah nganjuk, daun bawang kucai dan bawang prei secara berurutan menghasilkan nilai IC50 secara berurutan sebesar 257,75ppm; 41,46ppm; 384,03ppm; 312,79ppm; dan 61,05ppm. Diantara kelima jenis bawang yang memiliki aktivitas antioksidan tertinggi adalah bawang dayak, disusul dengan bawang prei yang masuk dalam kategori kuat. Dengan demikian bawang Dayak dan bawang prei dapat digunakaan sebagai sumber antioksidan dalam suplemen kesehatan.

Co-Authors Dhini Tri Wilujeng Dzikra Nasyaya Mahfudhah Jihan Shofwatul Islam Dalilah Aziz Lailatul Wakhidah Mufidatul Ilmiah Rizki Amalia Shela Insanul Hikmah

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