Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Unesa Journal of Chemistry
First Ambar Wati
Departemen Kimia, Universitas Negeri Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
POTENSI SENYAWA EUGENOL DARI CENGKEH (Syzygium aromaticum) SEBAGAI INHIBITOR PROTEASE HIV-1 (PR) Ahmad Misbakhus Sururi; Dina Kartika Maharani; First Ambar Wati
Unesa Journal of Chemistry Vol 12 No 1 (2023)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.624 KB) | DOI: 10.26740/ujc.v12n1.p26-30

Abstract

Syzygium aromaticum is a medicinal plant that is well known for its uses in the medical world. This plant contains essential oil that has a lot of bioactivitis, namely eugenol. This study aims to determine the potency of the compound eugenol and its derivatives as an inhibitor of HIV-1 protease (PR), an HIV-1 antiviral candidate. The ligands used in this study were eugenol, methyl eugenol, acetyl eugenol, and isoeugenol. The results showed that the compound acetyl eugenol has the potential to act as an HIV-1 protease inhibitor better than other eugenol derivatives because it has a lower binding affinity value (-6.2 kcal/mol) of the other compounds. Further studies such as in vitro and in vivo tests are needed to prove its activity as an HIV-1 protease.
Co-Authors Ahmad Misbakhus Sururi Dina Kartika Maharani