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All Journal ALCHEMY Jurnal Penelitian Kimia
Arifah Khusnuryani
Prodi kimia, Fakultas Sains dan Teknologi, UIN Suka Yogyakarta
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

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SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE Susy Yunita Prabawati; Arifah Khusnuryani; Khamidinal Khamidinal
ALCHEMY Jurnal Penelitian Kimia Vol 13, No 1 (2017): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.13.1.4324.95-102

Abstract

The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR and 1H-NMR spectrometer. The  product was obtained as a orange solid which has a melting point at    58 - 59 ˚C. Identification of the product by IR spectrophotometer showed the absorption of  C=C in the wavenumber of 1496.76 cm-1 which confirmed that the hydration reaction of chalcone had occurred. Analysis using 1H-NMR spectrometer also showed the proton of the CH=CH appearing on chemical shift (δ) 7.99 ppm. The antibacterial activity test showed that the compounds of 3-methoxy-4- hydroxychalcone has a potential as an antibacterial against bacteria E. coli and B. subtilis.
Co-Authors Khamidinal Khamidinal Susy Yunita Prabawati