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All Journal PCJN Pharmaceutical and Clinical Journal of Nusantara
Jonathan Makuwira
Malawi University of Science and Technology, P.O Box 5196, Limbe, Malawi.
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Analysis of Embryo Development and Early Performance of Larvae of Barbonymus Schwanenfeldii: A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.947 KB) | DOI: 10.58549/pcjn.v1i01.3

Abstract

Tengadak fish is a freshwater fish that can be found in rivers, lakes and canals and ditches. One of the important phases in fish development is the embryo. Embryo development (embryogenesis) is more in the process of formation and development of the embryo, not only the increase in the number and mass of embryonic blastomer cells but also the activity of blastomeric cells.The purpose of this study was to analyze the stages of embryonic development and early larval performance in Tengadak fish (Barbonymus schwanenfeldii). This study used systematic literature review using data from PubMed, NCBI, Google Scholar databases using keywords, namely, “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. Approximately, 350 articles were obtained for the keywords “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. All articles were selected based on inclusion criteria and exclusion and obtained as many as 27 articles that meet the inclusion criteria From the results of research conducted, it can be concluded that this research has sequentially described the embryonic development and early performance of the larvae of the barbonymus schwanenfeldii. Need research on the other animal for future research.
Analysis Of Medicinal Plants On Embryo Development Of Mice (Mus Musculus L.) And White Rats (Rattus Novergicus): A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.217 KB) | DOI: 10.58549/pcjn.v1i01.4

Abstract

White rats are often used to assess protein quality, toxicity, carcinogenic, and pesticide content of an agricultural food product. M. Musculus mice are rodents that are very easy to breed, and easy to maintain. Embryogenesis is the process of growth and development of the embryo. The purpose of this study was to analyze medicinal plants on the embryonic development of Mice (Mus musculus L) and White Rats (Rattus Novergicus). This method uses a Systematic Review approach which is based on the Preferred Guide to Reporting Items for Systematic Review and Meta-analysis (PRISMA). Total of 700 articles were obtained which then entered the elimination stage resulting in 50 articles on medicinal plants (Mus musculus L) and White Rats (Rattus Novergicus). Based on the results of the study, it can be concluded that the identification of medicinal plants that are toxic to the embryonic development of Mice (Mus musculus L.) White Rats (Rattus Novergicus).
Apis Mellifera Propolis Extract As A Stimulator Of Brain Cell Development (Study On Experimental Animals) Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.011 KB) | DOI: 10.58549/pcjn.v1i01.5

Abstract

Apis mellifera could have potential as cell growth stimulator ability of the propolis. It also expected to increase the growth and proliferation of brain cells. This study aimed to analyze Apis mellifera Propolis Extract as a Stimulator of Brain Cell Development in Experimental Animals. This research is an experimental study using a completely randomized design (CRD) with 6 treatments and 4 replications. The research consisted of making Propolis Extract, Making Media (DMEM Stock Media, Washing Media, Culture and Treatment Media), Brain Cell Isolation and Culture, Observation of Culture Results (Cell Viability, Population Doubling Time, The results found that all treatments with propolis extract showed higher average viability than the control, which had average viability of 86.3%. Based on PDT (Population Doubling Time value), propolis extract has a good effect on brain cell growth, hence increasing cell proliferation. In addition, the confluent brain cells of rats given propolis extract had higher average confluency than those not given propolis extract. Propolis extract can protect neurons from damage by increasing the brain-derivatedneurotrophic factor (BDNF) gene expression in cell line neuron cultures.
Testing Honey on Chicken Embryos as Candidates for Herbal Medicine in Indonesia Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.052 KB) | DOI: 10.58549/pcjn.v1i01.6

Abstract

The nutrients in honey had function as antioxidants. The aim of this study was to testing honey on chicken embryos as candidates for herbal medicine in Indonesia. This study used treatment method, consisting of 6 (six) doses of honey products. The solution volume of each treatment dose was fixed at 10 l/egg via the route to the air bag. At the age of 13 days, embryo morphology and possible abnormalities were observed in all treatments. Each two eggs are cracked. The remainder was continued by incubation in the incubator until day 21. During this time the eggs were observed and the number was recorded to find out which eggs would die and which eggs would hatch at the end of the incubation period. Newborn chicks (DOC) were weighed and observed for possible morphological abnormalities. From the results of the research conducted, it was found that the percentage of viable chicken eggs sprouted after being injected with honey (days 13-21 after inoculation) and the morphology of chicken embryos after being injected with honey. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. The conclusion of the study is that propolis from honey products can be used as herbal medicine.
Co-Authors Mafruchati, Maslichah