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Amitasari Damayanti
Program Studi Farmasi Universitas Hang Tuah
Medicine & Pharmacology

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Review Interaksi Obat-Obat Potensial Terapi Antibiotik Pada Infeksi Saluran Pernafasan Pasien Anak Rawat Inap Di Rumah Sakit Ainaya Rizqiah; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.41

Abstract

Drug interaction is a pharmacological or clinical response to the administration of drugs in combination or concurrently that can change the effectiveness of one drug with another drug. These effects can be dangerous if drug interactions lead to increased toxicity or decreased therapeutic effectiveness of a drug. Antibiotics are a treatment used for pediatric with respiratory infections. Overuse of antibiotics can lead to antimicrobial resistance. The purpose of the literature review study was to determine the types of antibiotic drug interactions and analyze the severity of antibiotic drug interactions in pediatric patients with respiratory tract infections who were hospitalized and carried out using the narrative review method. The results showed that there were interactions between antibiotics with antibiotics and antibiotics with other drugs with moderate and major severity, and there were types of pharmacokinetic and pharmacodynamic drug interactions in pediatric patients with respiratory tract infections.
KAJIAN EFEK INTERAKSI OBAT GOLONGAN STATIN DENGAN CALCIUM CHANNEL BLOCKER (CCB) TERHADAP RHABDOMIOLISIS Marathus Sholikhah Prihatini Sukma; Ana Khusnul Faizah; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.45

Abstract

Drug interaction is one of the factors that can affect drug activity in the body's response. Drugs can interact with chemicals, herbs, food, and other medications, thereby changing the drug's therapeutic effect. Drug interactions are common in hypertensive and hyperlipidemic patients receiving Calcium Channel Blocker (CCB) and statin therapy. This study uses a narrative review method to examine the effect of drug interactions between statins and calcium channel blockers from articles to analyze rhabdomyolysis. Secondary data is taken from the primary literature, namely journals or articles published in the database (Google Scholar, Pubmed). Drug interactions between statins and CCBs are known to have a severity level due to the administration of amlodipine and simvastatin. This severity can cause rhabdomyolysis and can be identified by pain, muscle weakness, urine color that looks like tea, and measuring CK levels that exceed expected levels (200 U/L). In this study, rhabdomyolysis was shown by increasing creatine kinase (CK) levels by ten times after simvastatin 20 mg and amlodipine 10 mg for one month; other studies also reported that CK levels increased up to 100,000 U/L given atorvastatin 80 mg and amlodipine 5 mg therapy. The effect of drug interactions between statins and CCBs that cause rhabdomyolysis can be detected as early as one month. Treatment of rhabdomyolysis due to drug interactions is replacing statin therapy (simvastatin instead of pravastatin or rosuvastatin).
KAJIAN EFEK SAMPING ANTIDEPRESAN TERHADAP FUNGSI SEKSUAL Vita Manda; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.49

Abstract

Depression is a mental health disorder that is a severe mood disorder characterized by the appearance of symptoms of a decrease in mood (mood), such as loss of interest, energy, concentration, and disturbances in appetite and sleep. One of the treatments for depression is the use of antidepressants. Still, sexual dysfunction has been reported as a side effect of using antidepressants, especially Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), and other antidepressants, namely Tricyclic Antidepressants (TCAs) have also been reported. ). Research results on the side effects of using antidepressant drugs have been reported to have decreased sexual arousal and impaired orgasm (orgasm development). There are side effects that occur in the use of SSRI, SNRI, and TCA antidepressants on sexual function
Co-Authors Ainaya Rizqiah Marathus Sholikhah Prihatini Sukma Vita Manda