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Editha Renesteen
Faculty of Military Pharmacy, The Republic of Indonesia Defense University
Medicine & Pharmacology

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IMMUNOREGULATION OF MULTIPLE SCLEROSIS BY HELMINTH THERAPY Editha Renesteen
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.019 KB) | DOI: 10.35617/jfionline.v12i2.49

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) which is characterized by the recruitment of T cells into the CNS, leading to demyelination and axonal damage. Currently, there are limited options for MS therapy, thus researchers start to use helminths therapy as a new therapeutic agent. Helminths are promising organisms to treat autoimmune diseases like MS by interfering the host’s immune responses. Several helminths, including Trichinella spiralis, Trichuis suis, Fasciola hepatica, Schistosoma japonicum and Schistosoma mansoni are under investigation in animal models for MS, experimental autoimmune encephalitis (EAE). Furthermore, Trichuis suis, Fasciola hepatica and Schistosoma mansoni are being examined in patients. This review outlines basic insight of MS, immunoregulation mechanisms induced by helminths, current helminths therapy for MS as well as helminths therapy for MS application in the future.
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