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All Journal Bioscientist : Jurnal Ilmiah Biologi
Diana Hernawati
Program Studi Pendidikan Biologi, FKIP, Universitas Siliwangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Social Sciences

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Pola Persebaran dan Keanekaragaman Kelomang di Zona Litoral Pantai Leuweung Sancang Kabupaten Garut Cinthiya O. B. A. Fau; Diana Hernawati; Diki Muhamad Chaidir
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 1 (2023): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i1.6767

Abstract

The littoral zone of Leuweung Sancang Beach, Garut Regency has very diverse biodiversity, such as hermit crabs. This study aims to determine the distribution patterns and species diversity of hermit crabs in the littoral zone of Leuweung Sancang Beach. This research was conducted from February 2022 to June 2022. This research uses quantitative methods and sampling techniques using a 100 meter transect belt which is divided into 100 plots with a size of 1 x 1 meter. The stations used are Cibako 1 station, Cikujang Jambe 2 station, and Ciporeang 3 station. The results of this study obtained data on the distribution pattern of hermit crabs on Leuweung Sancang Beach, namely clusters with an id value > 1 obtained data on the diversity of hermit crabs consisting of 3 family, 5 genus, and 13 species. The results of the calculation of the ecological index on hermit crabs show that the average density of hermit crab species is 15.73 ind/m2, the average diversity index is 1.27 includes the moderate diversity category, the average uniformity index is 0.52 includes the moderate uniformity category, and the average dominance index is 0.39 includes the category of moderate dominance.
Analisis In Silico : Aktivitas Senyawa Antibakteri dalam Zingiber aromaticum terhadap Salmonella typhi Ade Wina Utari Suherman; Diana Hernawati; Rinaldi Rizal Putra
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 1 (2023): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i1.7636

Abstract

Typhoid fever is an acute infectious disease of the small intestine caused by the bacterium Salmonella typhi. The prevalence of typhoid fever in the world is 27 million cases per year and causes 200,000 deaths. In Indonesia, it is estimated that the incidence of typhus is 148.7 per 100,000 people per year. Treatment of typhoid fever using ciprofloxacin antibiotics still causes bacterial resistance so that the discovery of herbal ingredients as an alternative to typhoid fever drugs is still being developed. This study aims to look at the potential of the active compound Zingiber aromaticum in terms of physicochemical prediction, pharmacokinetics, binding affinity, and level of toxicity. Previous studies have proven that Zingiber aromaticum has the potential to inhibit Pseudomonas aeruginosa and Salmonella typhi bacteria. The method used is molecular docking between the active compounds Zingiber aromaticum to be compared with the control drug ciprofloxacin as a comparison. As a result, all active compounds of Zingiber aromaticum have potential as drug candidates because they fulfill the lipinski’s rule of five. Zerumbon has the best pharmacokinetic profile compared to ciprofloxacin. Compounds in class 4, 5 and 6 are relatively safer, not mutagenic and not toxic to the liver compared to ciprofloxacin. The compounds that have a better binding affinity value than ciprofloxacin are isokaempferide, (-)-beta-Sitosterol, afzelin, kaempferol 3-(3'-acetylrhamnoside), and 3-O-beta-D-Glucopyranosyl sequentially namely -8,1 kcal/mol, -9.0 kcal/mol, -9.4 kcal/mol, -9.3 kcal/mol and -9.3 kcal/mol. The most valid compounds compared to ciprofloxacin are (-)-beta-sitosterol with RMSD l.b 1.513 and RMSD u.b 2.169.
Co-Authors Ade Wina Utari Suherman Cinthiya O. B. A. Fau Diki Muhamad Chaidir Rinaldi Rizal Putra