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All Journal International Journal of Integrative Sciences International Journal of Scientific Multidisciplinary Research (IJSMR)
Rehan Haider
Riggs Pharmaceutical Karachi, Department of Pharmacy, University of Karachi
Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Social Sciences

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Genetic Pharmacotherapy Rehan Haider
International Journal of Scientific Multidisciplinary Research Vol. 1 No. 4 (2023): May, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijsmr.v1i4.4374

Abstract

In current drug development, proof-of-concept—determining whether a ligand engaging its target is likely to be therapeutic—requires specific ligands. This presents a catch-22, as the motivation to develop ligands requires proof-of-concept studies that cannot be conducted without ligands. A strategy we term genetic pharmacotherapy—a refinement of genetic blockade focused on drug-gable targets—obviates the catch-22 by enabling proof-of-concept studies before the development of specific ligands via genetic means in mouse models. In this strategy, which could help avert investment in molecular entities that will ultimately prove therapeutically efficacious, a gene is conditionally down-regulated via a molecular switch in adult mice. Both the precise temporal control of the intervention and the consequent change in the target protein function parallels the administration of drugs, with the additional advantage of perfect specificity. Moreover, genetic pharmacotherapy overcomes the impediment of the blood-brain barrier, which makes developing ligands for psychiatric disorders particularly challenging                                                                                                       
Evolutionary Biology and Drug Development Rehan Haider
International Journal of Integrative Sciences Vol. 2 No. 6 (2023): June 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijis.v2i6.4392

Abstract

Evolution is the unifying framework in biology and scales to all dwelling systems. It is the central organizing questioning to grant clarification for reputedly disparate herbal phenomena; from the very small (individual molecules) to the very large (ecosystems), from the upward push and unfold of molecular editions to the habits and physique shapes of elephants. In modern times, our maintain shut for evolution in medicinal pills has acquired momentum. Individuals have championed the cause, dedicated journals have emerged, and new books on the trouble are often posted (“The Evolution and Medicine Review” is an terrific web-based advisable useful resource presenting up to date information on the subject, http://evmedreview.com). This union between evolution and cure has already most fulfilled our hold close of pathological techniques (Maccallum, 2007, Nesse & Stearns, 2008). Drug enchancment and therapeutic strategies are areas in which evolutionary standards would perchance moreover be specially helpful. The avalanche of bioinformatic methods, genomic data, and the subsequent emergence of evolutionary genomics in the ultimate few many years propose that integrating these fields into drug graphs is now a possibility. Incorporating evolutionary documents is now not completely really useful a posteriori when we might also moreover in addition hope to apprehend why resistance to a special compound emerged. It is in addition treasured a priori, to structure increased efficacious drugs, suggest possible resistance profiles and conceptualize novel therapeutic strategies
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