Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Klinik Indonesia Universa Medicina Majalah Patologi Indonesia Eduvest - Journal of Universal Studies
Birgitta M. Dewayani, Birgitta M.
Unknown Affiliation
Aerospace Engineering Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Ekspresi Negatif Melanoma Cell Adhesion Molecule (MCAM) Berkorelasi dengan Metastasis Kelenjar Getah Bening Aksila pada Triple Negative Breast Cancer Nurwenda, Sartika; Dewayani, Birgitta M.; Afiati, Afiati; Hernowo, Bethy S.
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1263.621 KB)

Abstract

  Triple negative breast cancer (TNBC) adalah karsinoma payudara yang memiliki ekspresi negatif untuk estrogen receptor (ER), progesteron receptor (PR), dan Human Epidermal Growth Factor Receptor (HER2). TNBC memiliki sifat agresif, frekwensi metastasis ke Kelenjar Getah Bening (KGB) aksila yang tinggi, prognosis yang buruk, dan rekurensi yang tinggi. Metastasis ke KGB aksila akan mempengaruhi angka kesintasan hidup dan angka rekurensi penderita TNBC. Melanoma cell adhesion molecule (MCAM) adalah membran glikoprotein dari superfamili imunoglobulin, yang terlibat di dalam ikatan antar sel, yang kemudian dikenal sebagai marker untuk progresi dan metastasis melanoma dan karsinoma prostat. Namun, peran MCAM pada karsinoma mammae masih kontroversial. Tujuan penelitian ini untuk menilai korelasi ekspresi MCAM dengan metastasis ke KGB aksila pada TNBC. Penelitian ini dilaksanakan pada periode 1 Januari 2010–31 April 2015 di laboratorium Patologi Anatomi Fakultas Kedokteran, Universitas Padjadjaran. Penelitian ini dilakukan menggunakan desain potong lintang analisis korelasi dengan menggunakan uji korelasi lambda. Pewarnaan imunohistokimia MCAM dilakukan terhadap 56 sampel blok parafin dari kelompok TNBC yang tidak bermetastasis dan telah bemetastasis ke KGB aksila. Sebanyak 22 dari 28 (78,6%) orang TNBC yang telah bermetastasis ke KGB aksila memiliki nilai histoskor MCAM <4 (negatif), sebaliknya 16 dari 28 (57,1%) orang TNBC yang tidak bermetastasis ke KGB aksila memiliki nilai histoskor ≥4 (positif). Ketiadaan ekspresi MCAM berkorelasi dengan metastasis TNBC ke KGB aksila, namun bukan satu-satunya faktor penentu metastasis.Kata kunci: KGB, metastasis, MCAM, triple negative breast cancer Negative Expression of Melanoma Cell Adhesion Molecule (MCAM) Correlated with Axillary Lymph Node Metastasis in Triple Negative Breast Cancer Triple negative breast cancer (TNBC) is breast cancers that demonstrate the absence of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. TNBC has an aggressive behaviour, high frequency of metastases to the axillary lymph nodes and recurrence, and poor prognosis. Metastasis to the axillary lymph nodes will affect the rate of survival and recurrence in TNBC. Melanoma cell adhession molecule (MCAM) is a membrane glycoprotein of the immunoglobulin superfamily, which is involved in the cells binding, which later became known as the marker for the progression and metastasis of melanoma and carcinoma of the prostate. However, MCAM role in mammary carcinoma still kontroversial. The aim of this study was to assess correlation between MCAM expression with incidence of metastatic to axillary lymph nodes in TNBC. This research was conducted during January 1st 2010–April 31st 2015 at Pathology Anatomy, Faculty of Medicine, Universitas Padjadjaran. This study used a cross-sectional design, using lambda correlation test. MCAM immunohistochemical staining performed on 56 samples of paraffin blocks of TNBC group that did not metastasized and has metastasized to the axillary lymph nodes. A total of 22 of 28 (78.6%) of TNBC metastatic to axillary lymph nodes have histoskor MCAM value <4 (negative), whereas 16 of 28 (57.1%) of TNBC non metastatic have histoskor value ≥ 4 (positive). Negative expression of MCAM correlated with TNBC that had metastasized to axillary lymph nodes, although not the only factor that influenced them.Keywords: Lymph node, metastasis, MCAM, triple negative breast cancer
Paclitaxel-carboplatin chemotherapy induced hematologic toxicities among epithelial ovarian cancer patients Charles, Afandi; Dewayani, Birgitta M.; Sahiratmadja, Edhyana; Winarno, Gatot N.A.; Susanto, Herman
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.165-170

Abstract

BackgroundEpithelial ovarian cancer (EOC) is one of the most common cancers diagnosed in Indonesian women. A combination of paclitaxel and carboplatin is used to treat EOC as standard chemotherapy which is known to have hematologic toxicities. This study aimed to investigate the effect of combined paclitaxel-carboplatin chemotherapy on hematologic status in EOC patients managed at Dr. Hasan Sadikin General Hospital, Bandung, West Java.MethodsAll patients with confirmed pathological diagnosis of EOC at Dr. Hasan Sadikin General Hospital in the period of 2013 to 2014 were registered. Only patients with complete hematologic data before and after chemotherapy were collected and compared using the paired non-parametric Wilcoxon and McNemar tests. ResultsIn total there were 147 patients with EOC (median age 46 ± 12 years), with the most dominant pathological diagnosis of mucinous (32.7%) and serous (29.3%) types. Only 33 patients had hematologic data before the initiation of chemotherapy. There was a significant decrease after chemotherapy including hemoglobin level (12.0 vs 10.9 g/dL, p=0.013), erythrocyte count (4.53 vs 3.74 million/mL, p&lt;0.001), leukocyte count (7,700 vs 4,000/mm3 p&lt;0.001) and platelet count (343,000 vs 215,000/mm3, p&lt;0.001). Interestingly, anemia cases after chemotherapy were predominant (87.9%) compared with erythopenia, leukopenia, thrombocytopenia i.e. 39.4%, 57.6%, and 27.3% respectively. ConclusionsThis study confirmed the hematologic toxicities after paclitaxel-carboplatin chemotherapy in EOC patients treated in Hasan Sadikin General Hospital, West Java. The hemoglobin concentration may serve as prognostic factor. Further studies directed to other factors such as genetic factor for polymorphisms may be encouraged to explore the decrease of the hematologic indices.
Clinicopathological Features of Ovarian Adult Granulosa Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2019 to 2025 Irma Melati, Ganda; Dewayani, Birgitta M.; Primastari, Etis
Eduvest - Journal of Universal Studies Vol. 5 No. 10 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i10.52256

Abstract

Adult granulosa cell tumor (AGCT) is the most common ovarian sex cord–stromal tumor (SCST), comprising approximately 70% of cases. It is a low-grade malignant neoplasm with a tendency for late recurrence and metastasis. Tumor stage and rupture in stage I disease are the most important prognostic factors. This study aimed to describe the clinicopathological characteristics of AGCT patients treated at Dr. Hasan Sadikin General Hospital, Bandung, from 2019 to 2025. This observational analytic study included 46 women who underwent surgical resection and were histopathologically diagnosed with AGCT with documented International Federation of Gynecology and Obstetrics (FIGO) stage at Dr. Hasan Sadikin General Hospital between 2019 and 2025. Sampling was consecutive. Variables observed included age, FIGO stage, laterality, ascites, surgical procedures, tumor size, histopathological pattern, mitotic count, necrosis, lymphovascular invasion, endometrial pathology, and adjuvant chemotherapy. Data were analyzed descriptively. The mean age of patients was 47 years (range 19–63). The mean tumor size was 23.7 cm, and most tumors (82.6%) measured ≥10 cm. Nearly all were unilateral (97.8%), with slight predominance in the right ovary (54.3%). Ascites was present in 56.5% of patients. Histologically, 89.1% exhibited multiple admixed growth patterns with low mitotic activity. Necrosis and lymphovascular invasion were observed in 30.4% and 17.4% of cases, respectively. Endometrial alterations were rare (6.5%). Stage distribution was 47.8% stage I, 2.2% stage II, 41.3% stage III, and 8.7% stage IV. Adjuvant chemotherapy was administered to 50% of patients, most frequently paclitaxel–carboplatin (60.8%).
Relationship Between Histopathology Grading (Nottingham System) and Expression of HER2/Subtype Luminal B in Breast Carcinoma with Lymph Node Metastases Irmaya, Dita; Hernowo, Bethy S.; Dewayani, Birgitta M.
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.650

Abstract

Background Molecular subtypes of breast carcinoma, histological grade, and lymph node msetastases are significant in determining the therapy and prognosis of the patient. The luminal B subtype comprises 15%-20% of breast cancers and has a more aggressive phenotype, higher histological grade, proliferative index, and a worse prognosis. This study aimed to evaluate the relationship between histopathological grading and expression of  HER2 with lymph node metastases in luminal B subtype breast carcinoma. Methods We analyzed 279 invasive breast carcinoma luminal-B subtypes from the anatomic pathology laboratory of Dr. Hasan Sadikin Bandung between January 2017 and March 2023. Histological grade using the Nottingham system, expression of HER2 using immunohistochemistry examination, and lymph node metastases status were obtained from anatomic pathology records. The association between histological grade and expression of HER2 with lymph node metastases was examined with chi-square tests. Result: In the current study, we included 279 subjects, dominated by patients whose age at diagnosis was less than 50 years old. The Chi-square analysis showed no statistically significant difference in tumor size between patients with metastasis and those without metastasis,P = 0.74. The Chi-square analysis showed a significant relationship between histopathological grade and lymph node metastases, p < 0.01 and expression HER2 status and lymph node metastasis  p < 0.05 Conclusion This study found that patients present with larger tumors classified as T3 and moderate to poor grade III and grade II histological grades. The statistical analysis showed no significant difference in the age of diagnosis between patients with metastasis and those without. However, the Chi-square analysis revealed a significant correlation between the histopathological grade and HER2 expression with lymph node metastasis.
Co-Authors Afandi Charles, Afandi Afiati Afiati Bethy S. Hernowo Edhyana Sahiratmadja Gatot N.A. Winarno Herman Susanto Irma Melati, Ganda Irmaya, Dita Nurwenda, Sartika Primastari, Etis