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All Journal Jurnal Kedokteran Diponegoro Ophthalmologica Indonesiana
Nugraha Adiyasa
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Health Professions Medicine & Pharmacology Public Health

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PERBANDINGAN PEMBERIAN BRODIFAKUM DOSIS LD50 DAN LD100 TERHADAP RESIDU BRODIFAKUM PADA HEPAR TIKUS WISTAR Nugraha Adiyasa; Tuntas Dhanardhono; Sigid Kirana Lintang Bhima
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.164 KB) | DOI: 10.14710/dmj.v5i4.15597

Abstract

Latar Belakang : Brodifakum adalah senyawa yang umumnya digunakan sebagai racun tikus. Namun, sering disalah gunakan pada kasus kriminal. Brodifakum akan di metabolisme tubuh melalui organ ekskresi diantaranya hepar. Paparan brodifakum dalam dosis yang berbeda akan menghasilkan kadar residu yang berbeda pula.Tujuan: Mengetahui perbandingan pemberian brodifakum dosis LD50 dan LD100 terhadap jumlah residu brodifakum pada hepar tikus wistar.Metode: Penelitian ini merupakan penelitian eksperimental dengan menggunakan pendekatan post test only control group design. 27 sampel tikus wistar diberikan perlakuan pemberian brodifakum secara per oral. Residu brodifakum dideteksi menggunakan High Performance Liquid Chromatography. Dilakukan analisa deskriptif, uji non parametrik Mann-Whitney terhadap data. Hasil analisis dinyatakan bermakna bila nilai p<0,05.Hasil: Konsentrasi brodifakum pada hepar hewan coba meningkat berdasarkan jumlah brodifakum yang dimakan. Tikus mati pada hari ke-3 sebanyak 4, pada hari ke-5 sebanyak 7 dan pada hari terminasi sebanyak 16 tikus diterminasi. Kadar residu terendah didapatkan pada angka 0,00002 mg/kg dan tertinggi pada angka 0,00100 mg/kg. Uji Mann-Whitney didapatkan hasil perbandingan residu brodifakum pada hepar tikus pada dosis kontrol dan LD50 (p=0,001) dan pada kontrol dan LD100 (p=0,000). Antara jumlah residu brodifakum pada hepar tikus pada dosis LD50 dan LD100 (p=0,539).Simpulan: Tidak ada perbedaan bermakna antara jumlah residu brodifakum pada hepar tikus pada dosis LD50 dan LD100 (p=0,539).
Comparison of Endothelial Cell Loss after Phacoemulsification Surgery between Patients with Diabetes Mellitus and Non-Diabetic Patients at Kariadi Hospital: A Prospective Study: Oral Presentation - Observational Study - Resident Nugraha Adiyasa; Wisnu Sadasih; A. Rizal Fanany
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/90mnqv03

Abstract

Abstract Introduction & Objectives : To compare the endothelial cell loss after phacoemulsification surgery in patients with DM and non- DM patients Methods : This was a prospective study conducted at Kariadi Hospital, Semarang, Indonesia. A total of 20 eyes of 20 patients (10 DM and 10 non-DM) who underwent phacoemulsification surgery were included in this study. The central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX) were measured preoperatively and on day-7 postoperatively. The percentage of endothelial cell loss (%ECL) was calculated and compared between the two groups. Results : The mean pre-operative and post-operative CCT was similar in both groups (DM =546.6±44.26μm, non-DM=516.7±42.2μm, p=0.949 ;DM=562.8±46.1μm, non-DM=533.7±46.6μm, p=0.997). The mean percentage of endothelial cell loss was slightly higher in the DM group compared to the non- DM group but not significant (6.66±2.36% vs. 2.31±1.72%, p=0.566). There were no significant differences between the CV and HEX on pre-operative and day-7 after surgery Conclusion : Patients with DM have a slightly higher percentage of endothelial cell loss after phacoemulsification surgery compared to non-DM patients. The mean CCT, CV and HEX pre-operation and day-7 were quite similar in both groups. These findings suggest that patients with DM may require more careful monitoring and follow-up after phacoemulsification surgery.
Co-Authors A. Rizal Fanany Sigid Kirana Lintang Bhima Tuntas Dhanardhono Wisnu Sadasih