Kristy Iskandar
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan, Unviersitas Gadjah Mada/ Rumah Sakit Akademik Universitas Gadjah Mada, Yogyakarta

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Studi Prospektif pada Anak dengan Manifestasi Neurologi yang Terinfeksi SARS-CoV-2 di Rumah Sakit Umum Pusat Dr. Sardjito, Yogyakarta Kristy Iskandar; Agung Triono; Alexandra Widita Swipratami; Yunika Puspa Dewi; Marissa Leviani Hadiyanto; Ignatia Rosalia Kirana; Salsabilla Hasna Mutiara Rizki; Elisabeth Siti Herini
Sari Pediatri Vol 25, No 1 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.1.2023.1-6

Abstract

Latar belakang. Infeksi virus SARS-CoV-2 dilaporkan menyerang anak-anak dengan prevalensi 1-5% kasus di dunia. Manifestasi neurologis dapat terjadi pada fase akut maupun subakut infeksi SARS-CoV-2. Gejala neurologi telah ditemukan pada 9,2% pasien anak dengan COVID-19 dan berhubungan dengan perburukan kualitas hidup serta prognosis pasien. Tujuan. Penelitian ini bertujuan untuk mendeskripsikan kejadian infeksi SARS-COV-2 pada anak dengan manifestasi neurologi di Rumah Sakit Umum Pusat Dr. Sardjito pada tahun 2021.Metode. Penelitian deskriptif prospektif ini mengambil subjek pasien berusia 0-18 tahun dengan manifestasi neurologi yang dirawat di Rumah Sakit Umum Pusat Dr. Sardjito pada Januari 2021 sampai Januari 2022. Pemeriksaan konfirmasi SARS-CoV-2 dilakukan dengan swab tenggorokan dan cairan serebrospinal yang dianalisis melalui polymerase chain reaction dan/atau antibodi Immunoglobulin G dan M serum.Hasil. Infeksi SARS-CoV-2 ditemukan pada 45,5% pasien ensefalitis/ensefalopati, 30,3% pasien status epileptikus, 21,2% pasien epilepsi, 21,2% pasien gangguan neuromuskular, dan 12,1% pasien stroke. Delapan belas pasien (54,5%) memenuhi kriteria MIS-C. Tidak ditemukan hubungan signifikan antara luaran pasien dengan insidensi infeksi SARS-CoV-2 (p=0,4).Kesimpulan. Infeksi SARS-CoV-2 positif ditemukan cukup tinggi pada pasien dengan manifestasi neurologi. Kejadian multisystem inflammatory syndrome meningkat pada pasien anak dengan manifestasi neurologi yang terinfeksi SARS-CoV-2 sehingga memerlukan pengawasan.
Increasing the Health-Related Quality of Life in Children with Congenital Rubella Syndrome: A Mixed-methods Study Elisabeth Siti Herini; Agung Triono; Kristy Iskandar; Ashadi Prasetyo; Albaaza Nuady; Marissa Leviani Hadiyanto; Kania Diantika; Veronica Wulan Wijayanti; Avianti Pramastuti
Journal of Community Empowerment for Health Vol 6, No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.80029

Abstract

Introduction: Rubella infection during the first trimester of pregnancy is a significant cause of fetal malformation syndrome, or Congenital Rubella Syndrome (CRS), which affects the children’s quality of life (QoL). A Community Engagement Program was arranged collaboratively to increase the QoL of children with CRS and enhance parents’ skills and knowledge to better care for their children with CRS. Methods: A mixed-method descriptive study was conducted from April to October 2022 at Dr. Sardjito General Hospital. Sample recruitment used the purposive sampling method, which had been clinically and serologically diagnosed with CRS. Children’s QoL data were analyzed with a cross-sectional study design. The tools used were the Pediatric Quality of Life Inventory (PedsQL)TM 4.0 Generic Core Scales and SPSS version 26 to analyze paired T-tests. A focus group discussion (FGD) was used for qualitative thematic analysis. Results: We involved ten members willing to participate voluntarily in the PedsQL assessment and FGD. The result was an increase in patients’ QoL in the Physical Function domain that was statistically significant: pre-test and post-test physical health summary [490 (±261) vs. 510 (±251); p=0.022]. While social, emotional, and school functions increased were not statistically significant. From the FGD, the parents had diverse experiences and understanding of CRS-supporting examinations and treatments needed. Parents felt the children’s growth and development, as social and school functions were the common burdens. In order to help CRS prevention, the parents suggested a more comprehensive premarital program and antenatal care. Conclusions: The Community Engagement Program helps to increase the patient’s QoL in the Physical Function domain. Comprehensive multidiscipline management is needed to support children’s growth, social and educational functions. Periodic evaluations are required to monitor the QoL of children with CRS.