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All Journal Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas
M. Artabah Muchlisin
Department of Pharmacy, Faculty of Health Sciences, University of Muhammadiyah Malang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Jejaring Farmakologi Tanaman Jati Belanda (Guazuma ulmifolia Lamk.) Sebagai Imunomodulator Nour Lena; Ahmad Shobrun Jamil; M. Artabah Muchlisin; Irsan Fahmi Almutahrihan
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.20782

Abstract

Covid-19 merupakan wabah penyakit yang menginfeksi sistem pernafasan pada manusia. Kasusnya terjadi hampir di seluruh negara di dunia dan keberadaannya sangat meresahkan karena penyebarannya terjadi dengan sangat cepat. Salah satu upaya yang dapat dilakukan untuk mencegah penyebaran penyakit Covid-19 adalah dengan meningkatkan sistem imun. Sistem imun melindungi tubuh dari infeksi dengan memproduksi molekul protein yang disebut antibodi yang mengikat antigen agen infeksi. Berdasarkan studi literatur yang telah dilakukan, beberapa tanaman lokal Indonesia memiliki potensi sebagai imunomodulator. Fokus penelitian ini ditujukan untuk mengetahui jejaring protein yang terkait dengan sistem imun tubuh yang teraktivasi karena pemberian ekstrak tanaman jati belanda (Guazuma ulmifolia Lamk.). Metode penelitian yang digunakan adalah deskriptif eksploratif berdasarkan online database dan web server (KNApSAck Family, Dr. Duke’s Phytochemical and Ethnobotanical Databases, SwissTargetPrediction, GeneCards, SwissADME, Venny, dan StringDB). Berdasarkan hasil penelitian, tanaman G. ulmifolia mengandung 17 senyawa metabolit sekunder, lima diantaranya memiliki bioavailabilitas yang tinggi meliputi ent-catechin, (-)-epigallocatechin, caffeine, kaempferol, dan quercetin. Senyawa (-)-epigallocatechin diprediksi dapat berinteraksi dengan MAPK14 yang memiliki koneksi dengan lima jalur penting dalam imunomodulator yaitu Fc epsilon RI signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, THF17 cell differentiation, TNF signaling pathway, dan IL-17 signaling pathway.
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators M. Helmi; Ahmad Shobrun Jamil; M. Artabah Muchlisin; Irsan Fahmi Almuhtarihan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
Co-Authors Ahmad Shobrun Jamil Irsan Fahmi Almuhtarihan Irsan Fahmi Almutahrihan M. Helmi Nour Lena