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All Journal Jurnal Penyakit Dalam Indonesia Journal of General Procedural Dermatology and Venereology Indonesia
Ramadan, Edwin Ti
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Medicine & Pharmacology

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Low-calorie diet improves PASI score in psoriasis patients with obesity: An evidence-based case report Kuniawan, Kristian; Fahira, Alessa; Ramadan, Edwin Ti; Budianti, Windy Keumala
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
Publisher : UI Scholars Hub

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Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction.Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text.Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters.Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management.
Two-point Compression POCUS sebagai Metode Diagnosis Dini Trombosis Vena Dalam Proksimal Ramadan, Edwin Ti; Maharani, Sausan Hana; Cahyanur, Rahmat; Priantono, Dimas; Rajabto, Wulyo
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 2
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Deep vein thrombosis (DVT), especially in the proximal part of the lower extremity, might progress to pulmonary embolism and be fatal. Therefore, it is crucial to prompt the diagnosis of DVT in the emergency room (ER). Due to its efficiency and patient convenience, duplex ultrasound has become the preferred diagnostic method for DVT. Point-of-care ultrasonography (POCUS) was known as a simpler and faster way to use ultrasonography at the bedside. The two-point compression method has become frequently used due to its ability to take less time for examination, yet there are still concerns about its accuracy. This study was conducted to find out whether two-point compression POCUS can be used as an early diagnostic method for proximal DVT. The literature search was carried out in the databases PUBMED, EMBASE, and SCOPUS on March 29, 2023, using keywords “Deep Vein Thrombosis”, “two-point compression POCUS”, and “diagnosis”. Four publications were chosen from the search results. One cross-sectional study was found to have a low validity value because POCUS and Doppler ultrasound operators were not blinded, and the reference test was only performed on positive DVT results on POCUS. All studies had high sensitivity and specificity (>90%) compared to the reference test, except for one cross-sectional study in critical patients in ICU, which had a 63% sensitivity value. In conclusion, the two-point compression POCUS method can be utilized as an early diagnostic method for proximal DVT, with the disclaimer that POCUS operators should get curriculum-based training before doing the examination.
Co-Authors Dimas Priantono, Dimas Fahira, Alessa Kuniawan, Kristian Maharani, Sausan Hana Rahmat Cahyanur Windy Keumala Budianti Wulyo Rajabto