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All Journal Jurnal Buana Farma Journal of Pharmaceutical and Sciences.
Nurasni Nurasni
Program Studi Farmasi Klinis, Universitas Prima Indonesia. Medan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Antidiabetes Fraksi Etil Asetat Daun Seledri (Apium graveolens L.) Terhadap Tikus Jantan Wistar (Rattus norvegicus) Rena Meutia; Novitaria br Sembiring; Octavian Ashido Nababan; Nerly Simanjuntak; Erida Novriani; Nurasni Nurasni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.368 KB) | DOI: 10.36490/journal-jps.com.v6i2.40

Abstract

The high population of diabetic patients every year is increasing, with the number of diabetic patients increasing by 463,000 in 2019. Estimates of Idiabetic foot in 2045 the number of the diabetic patient will be 700.000.000 patients. Celery leaves are used as an anti-diabetic (Apium graveolens L.). This study aimed to determine the anti-diabetic activity of the ethyl acetate fraction in celery leaves against male Wistar rats. Celery leaf Simplicia powder was extracted with 70% ethanol solvent in the maceration method. After obtaining 70% ethanol extract, then fractionation of n-hexane, ethanol-water, and ethyl acetate was carried out. The anti-diabetic test of the ethyl acetate fraction on celery leaves used the compound alloxan at a dose of 150 mg/kg BW. This study obtained the results of the ethyl acetate fraction in celery leaves at a dose of 300 mg/kg, which had the highest anti-diabetic activity with a reduction percentage of 65% compared to the positive control with a reduction percentage of 64%. The contents of chemical compounds from the ethyl acetate fraction in celery leaves are alkaloids, flavonoids and saponins.
UJI EFEKTIVITAS FORMULASI SEDIAAN SALEP FRAKSI ETIL ASETAT DAUN KOPASANDA (Chromoleana odorata L.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS JANTAN WISTAR (Rattus norvegicus) Nurasni; Neswita, Elfia; A’la, Nurul
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1687

Abstract

This study aimed to test the effectiveness of an ointment made from the ethyl acetate fraction of cotton apple (Chromoleana odorata L.) leaves in accelerating the healing of cut wounds in male white mice. Empirically, cotton apple leaves have long been used as a traditional medicine to treat wounds and infections. The objectives of this study were to assess the healing time, determine the most effective concentration, and compare the effectiveness of the ethyl acetate fraction ointment with a commercially available product. This was a laboratory experimental study with a post-test only control group design. Ointment formulations were prepared in three extract concentrations: FI (5%), FII (10%), and FIII (15%), each containing 1 gram, 2 grams, and 3 grams, respectively, and included positive and negative control groups. Effectiveness testing was conducted on experimental animals, comparing all treatment groups. Observed parameters included erythema, edema, and wound closure, measured by wound length using a ruler. The results showed that the FI formulation with a 10% concentration provided the fastest healing time, with wounds healing on average on the 10th day. Statistical analysis using ANOVA test (p < 0.005) showed that the ointment preparation of ethyl acetate fraction of cottonwood leaves was effective in accelerating the healing of cuts. Tukey's further test showed a significant difference between FI with KTP, KE, K-, FII, and FIII, but there was no significant difference between FII and povidone iodine ointment.
Co-Authors A’la, Nurul Erida Novriani Nerly Simanjuntak Neswita, Elfia Novitaria br Sembiring Octavian Ashido Nababan Rena Meutia