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All Journal Journal of Pharmaceutical and Sciences.
Lina Nurfadhila
Universitas Singaperbangsa Karawang, Jawa Barat, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Review: Analisis Senyawa Obat Warfarin dalam Plasma Darah dengan Metode HPLC/KCKT Siti Nafisa; Siti Rohmah; Yumareta Anggun Nihan; Lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.127 KB) | DOI: 10.36490/journal-jps.com.v6i2.143

Abstract

Warfarin is a synthetic derivative of coumarin whose use as an oral anticoagulant generally used to prevent and treat blood clots, prophylaxis also the treatment of pulmonary embolism, and thrombosis of venous, prophylaxis and treatment prophylaxis of thromboembolic complications from atrial fibrillation or replacement of heart valve, and the risk of death from recurrent myocardial infarction, and thromboembolic events after myocardial infarction can be reduced. Warfarin is a narrow therapeutic index of oral anticoagulants where if there is a slight change in the level of warfarin in the blood, a change in the effective response can occur. Many analytical techniques have been developed for the analysis of warfarin levels in blood plasma, for example using High-Performance Liquid Chromatography coupled with ultraviolet/fluorescence detection, SFC-MS/MS, LC-MS/MS, CZE with ultraviolet detection, and MEKC-ESI–MS. The test method used for monitoring this Review Article has the purpose of reviewing and comparing analytical methods/detection techniques used for the analysis of warfarin in blood plasma. The HPLC method has several advantages in the analysis of warfarin drug levels, such as ease, accuracy, effectiveness of analysis time, and advantages of high sensitivity and selectivity.
Analisis Kualitatif Senyawa Parasetamol Pada Sampel Biologis Menggunakan Metode Gas Chromatography - Mass Spectrometry (GC-MS) Siti Nuriah; Mutia Desvi Putri; Sri Rahayu; Chalisya Vanya Advaita; Lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.433 KB) | DOI: 10.36490/journal-jps.com.v6i2.158

Abstract

In this review article, an analysis was carried out regarding the use of the Gas Chromatography - Mass Spectrometry (GC-MS) method in the qualitative analysis of paracetamol compounds in various biological samples such as blood, serum, hair, and urine. Paracetamol is a non-opioid analgesic drug used to relieve mild to moderate pain. The method used in writing this article is a literature study using primary data in the form of national journals from the Google Scholar and Sinta databases. The search was carried out using keywords related to the qualitative analysis of paracetamol compounds using the GC-MS method on biological samples. The purpose of reviewing this article is to compare the treatment and preparation processes of various biological samples used in the qualitative analysis of paracetamol compounds using the Gas Chromatography - Mass Spectrometry (GC-MS) method, such as blood, serum, hair, and urine. The results of the study of several journals showed that there were several biological samples used in the qualitative analysis of paracetamol using the GC-MS method, namely blood, serum, hair and urine. Each biological sample has different preparation and extraction procedures according to the characteristics of the matrix. It can be concluded that of the four samples, hair samples can show positive results in a longer period of time while blood and urine samples can only provide drug information for a few days.
Co-Authors Chalisya Vanya Advaita Marsah Rahmawati Utami Mutia Desvi Putri Siti Nafisa Siti Nuriah Siti Rohmah Sri Rahayu Yumareta Anggun Nihan