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All Journal Andalas obstetrics and gynecology journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Science and Society (IJSOC)
Tutty Ariani
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Andalas /Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Clinical Appearance Of Tinea Corporis Resembles With Tinea Imbricata And Condyloma Acuminata Genital In A Reproductive Woman With HIV : A Case Report Indah Kencana; Tutty Ariani; Qaira Anum; Yosse Rizal
Andalas Obstetrics And Gynecology Journal Vol 5, No 2 (2021)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.287-302.2021

Abstract

Background: HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system that can cause immunodeficiency. Immunodeficiency results in increased susceptibility to fungal infections. The other opportunistic infection, condyloma acuminate is prevalent in groups at high risk for HIV acquisition and in HIV-infected individuals. Case: There were ring-shaped reddish patches with scaly and itchy on the right back since 3 weeks ago. Patients often scratch it especially when sweating and hot weather. The itchy reddish patches with scaly were increased in number and size on the right back then spreading over the edge to form ring-like patches. Patient complained ring-shaped reddish patches getting more red, scaly, itchy, and wider. 6 months ago, there was a lump that sometime felt itchy in below part of vulva. Patient in reproductive age and not married yet, but sexually active. Patient had a sexual relation with male who HIV 2 years ago. Patient also suffered HIV and got ARV since 6 month ago. There was no protection (condom) during the sexual intercourse. Dermatologic state in right back with efflorescence is plaque erythema with annular concentric ring forms, scale, and blackish crust. Venereologycal state show vegetation in vulva with size 0,2 - 1,5 x 1 x 0,5 cm with verrucous surface. Acetowhite test is positive result. KOH 10% of skin scrapping show fungal element and fungal culture result is tricophyton rubrum. Patient was diagnosed tinea corporis (TC) and condyloma acuminata (CA) genital griseovulfin 900 mg, cetirizin 10 mg, ketokonazol 2% cream twice a day, tricholoroacetat 90% and showed good improvement.Discussion: Diagnosis tinea corporis and CA genital based on clinical findings and mycological examination. Early diagnosis and proper treatment are important in HIV patients in order to prevent severe infection. After 4 weeks treatment, show improvement on TC however CA lesion no reduced. Keywords: tinea corporis,condyloma acuminate, tinea imbricata, HIV, Reproductive age
A Rare Case of Nail Lichen Planus Nolanda Trikanti; Rina Gustia; Tutty Ariani; Mutia Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.824

Abstract

Background: Nail lichen planus (NLP) is often associated with the involvement of other mucocutaneous sites. Though isolated nail involvement can be seen in a number of cases, it is seen in up to 10% of cases. Nail lichen planus is a rare case. This is the first case in the last 5 years in the dermatology and venereology department of Dr. M. Djamil Hospital Padang. Case presentation: A 26 years old woman came to the Dermatology and Venereology Department at Dr. M. Djamil Hospital Padang with all of her fingernails and toenails ridging, thinning, and brittle, and the color became yellow brown-blackish that worsened 6 months ago. This complaint had been suffered for 5 years ago. Dermatological examination showed onychodystrophy, longitudinal ridging and fissuring, yellow-brownish blackish discoloration on all fingernails and toenails, and there were no skin and mucosa lesions. The dermatology life quality index (DLQI) patient was 8. Potassium hydroxide (KOH) examination and fungal culture were negative. Histopathological examination showed hypergranulosis and sawtooth rete ridges. The patient was treated with clobetasol propionate 0,05% ointment with occlusion twice per day and showed improvement. Conclusion: Nail lichen planus can occur in the absence of skin or mucosal involvement. In this case, there is no skin or mucosal involvement. The diagnosis in this case is based on clinical, dermoscopic, and histopathological examination.
Performing Ocular Examinations as A Component of Self-Care For Individuals with Leprosy with The Aim of Eradicating Social Stigma and Prejudice Hendriati Hendriati; Tutty Ariani; Havriza Vitresia; Kemala Sayuti; Andrini Ariesti; Julita Julita; Qaira Anum; Satya Wydya Yenny; Rina Gustia; Gardenia Akhyar; Ennesta Asri; Indah Indria Sari; Astria Rima Rara Yuswir; Novian Novian; Rizki Dwayana; Agustin Vira; Rika Desviorita; Rendra Darma Satria
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.537-546.2024

Abstract

Leprosy is still a health problem in several countries, including Indonesia. Disability due to leprosy is a health threat for sufferers and causes quality-of-life problems that can disrupt the productivity of leprosy patients. Ocular involvement in leprosy is joint, but little data has been reported. Apart from multi-drug treatment (MDT), leprosy sufferers must also be able to carry out continuous self-care to prevent further disability. This is a collaborative activity between the Department of Ophthalmology and Dermatology Venereology of the Faculty of Medicine, the University of Andalas in Puskesmas Pauh Kamba district of Padang Pariaman. This is an advocacy activity on self-care (3M: Seeing, Examining, and Protecting) and eye examination. The activity was followed by interactive discussions and continued with a direct examination for skin abnormalities and disabilities, eye examination, and fundoscope. The activity results were obtained from 24 respondents, 11 men and 13 women. The age range is 16-59 years (67%), with the highest level of education being Elementry School graduates, which is 11 people (46%). In the self-care questionnaire of patients, 40% behaved well, and the results of eye examinations almost suffered from dry eye complaints without disabilities.
In Vitro Reduction of Antifungal Azole Sensitivity in Malassezia spp. and Resistance Prevention Strategies Sari Almira Taria; Tutty Ariani
International Journal of Science and Society Vol 8 No 3 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i3.1712

Abstract

Malassezia spp. are lipophilic yeasts that constitute part of the normal skin flora but are also implicated in various dermatological conditions, including pityriasis versicolor, seborrheic dermatitis, and folliculitis. In recent years, decreased in vitro antifungal susceptibility has been increasingly reported, potentially contributing to therapeutic failure and disease recurrence. Literature evaluating the minimum inhibitory concentration (MIC) patterns of azole agents and the molecular mechanisms of the decreased susceptibility in Malassezia spp. remains limited. Therefore, this literature review examines scientific articles related to the antifungal susceptibility of commonly used azoles against skin infections caused by Malassezia spp. Relevant publications were analyzed, focusing on in vitro studies, minimum inhibitory concentration (MIC) values, resistance mechanisms, and strategies for preventing antifungal resistance. Several studies demonstrate increased MIC values, particularly for azole antifungals such as fluconazole and ketoconazole. Fluconazole exhibited the highest MIC values (4 to >64 mg/L; MIC50 32 mg/L; MIC90 64 mg/L), whereas posaconazole showed the lowest (0.06–2 mg/L; MIC50 0.125 mg/L; MIC90 0.5 mg/L). Ketoconazole and itraconazole demonstrated relatively good antifungal activity, while amphotericin B showed moderate efficacy. Compared to Candida spp., Malassezia spp. generally exhibited higher MIC values, suggesting reduced susceptibility. Resistance mechanisms include ERG11 gene mutations, increased efflux pump activity, and biofilm formation. Decreased antifungal susceptibility in Malassezia spp. represents an emerging clinical concern with significant implications for treatment outcomes. Rational therapeutic approaches, including antifungal stewardship, susceptibility-guided therapy, and combination strategies, are essential to prevent resistance and improve clinical effectiveness.
The 15-Year Shadow: Borderline Lepromatous Leprosy with Erythema Nodosum Leprosum Following Prolonged Treatment Default Rendra Darmasatria; Tutty Ariani; Yosse Rizal; Rina Gustia; Irdawaty Izrul
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1405

Abstract

Background: Leprosy, caused by Mycobacterium leprae, persists as a global health issue where the primary challenges are not merely microbial but are deeply rooted in delayed diagnosis and poor treatment adherence. These delays, often driven by profound social stigma, lead to progressive, irreversible disability and sustain community transmission. Erythema Nodosum Leprosum (ENL), an acute immunological complication, further devastates patients' quality of life and complicates management. Case presentation: A 53-year-old Indonesian farmer presented with a 15-year history of untreated leprosy, a journey of neglect initiated by fear of treatment side effects and community ostracism. Clinical examination revealed advanced borderline lepromatous (BL) leprosy with diffuse skin infiltration, multiple anesthetic plaques, and thickened, tender peripheral nerves. He had established WHO Grade 1 disability, characterized by significant sensory loss in his hands and feet and early intrinsic muscle atrophy. A slit-skin smear confirmed a bacteriological index of +3 with a morphological index of 5%, indicating a high load of viable bacilli. Histopathology confirmed BL leprosy with a concurrent mild ENL reaction. A comprehensive, patient-centered management plan was initiated, including a 12-month course of multidrug therapy (MDT-MB), adjunctive care, and intensive counseling. Conclusion: This case powerfully illustrates the "shadow effect" of leprosy—how years of untreated disease, fueled by psychosocial barriers, culminate in a complex nexus of advanced infection, immunological reaction, and permanent neurological impairment. The patient's successful re-engagement with the health system underscores that eradicating the burden of leprosy requires a paradigm shift from a purely pharmacological approach to a deeply humanistic one. Effective control hinges on building compassionate health systems that actively dismantle stigma, empower patients with knowledge, and deliver holistic, multidisciplinary care to prevent the profound human cost of neglect.
Molecular Detection of Leprosy: A Literature Review Hersa Firda Kartika; Tutty Ariani
International Journal of Science and Society Vol 8 No 1 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i1.1608

Abstract

Leprosy is an infectious disease caused by the bacterium Mycobacterium leprae, which can lead to permanent damage to the skin, nerves, and tissues. Early diagnosis is crucial to prevent further complications. Molecular technology has emerged as a significant tool in enhancing the accuracy and speed of leprosy diagnosis. By employing techniques such as Polymerase Chain Reaction (PCR) and genetic analysis, bacterial DNA detection can be performed even at the early stages of infection, when clinical symptoms are not yet apparent. Additionally, this technology allows for the identification of different bacterial strains, providing insights into the epidemiology and transmission patterns of the disease. The application of molecular technology also has the potential to improve the monitoring of treatment effectiveness and resistance of therapy regiments. Although challenges remain in accessibility and implementation of this technology in countries with high prevalence, innovations in molecular diagnosis offer new hope for the control and eradication of leprosy globally. Further research and investment in healthcare infrastructure are essential to maximize the potential of this technology in the diagnosis and management of leprosy.
Co-Authors Agustin Vira Andrini Ariesti Anum, Qaira Astria Rima Rara Yuswir Ennesta Asri Gardenia Akhyar Hendriati, Hendriati Hersa Firda Kartika Indah Indria Sari Indah Kencana Irdawaty Izrul Julita Julita Kemala Sayuti Mutia Sari Nolanda Trikanti Novian Novian Rendra Darma Satria Rendra Darmasatria Rika Desviorita Rina Gustia Rizki Dwayana Sari Almira Taria Satya Wydya Yenny Vitresia, Havriza Yosse Rizal Yosse Rizal