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Marsah Rahmawati Utami

Universitas Singaperbangsa Karawang, Karawang, Jawa Barat, Indonesia.

Author-ID : 6278115

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Review Artikel: Validasi Metode Analisis Penetapan Kadar Parasetamol Dalam Sampel Biologis Dengan Berbagai Metode Tiwi Ambarati; Najla Yusiana Wahyudi; Saarah Hamidah Asmara Indratno; lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Paracetamol is one of the most widely used pain relievers and analgesic drugs by the public. Examination of drug concentrations in biological samples using appropriate methods is necessary to ensure drug quality and optimize drug therapy. Therefore, this literature study was conducted with the aim of determining paracetamol levels in biological samples and testing its validity with various methods. Literature research was carried out by searching for several research journal articles that had been published in 2013-2023, which were selected according to the inclusion and exclusion criteria. Six journals were obtained regarding the validation of analytical methods for determining paracetamol levels in biological samples using various methods such as Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), Mass Spectrometry-High Performance Liquid Chromatography (HPLC- MS), and Mass Spectrometry Ultra High-Performance Liquid Chromatography (UHPLC-MS). From the above review it can be concluded that the method of analyzing paracetamol compounds in biological samples can be carried out with these four methods where the results of the analytical methods namely accuracy, selectivity, linearity, precision, LOD, and LOQ all meet the requirements or set criteria.

Perbandingan Metode Analisis Kadar Senyawa dan Toksisitas Merkuri (Hg) dalam Sampel Biologis Priscinya Christiana Debora; Sofianti Hidayat; Mochamad Galuh Ryandha; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Mercury or mercury (Hg) is a type of metal as an organic and inorganic compound that can be found in nature and is spread in rocks, ores, soil, water and air. Mercury in the body can be detected in biological materials such as urine, blood, breast milk and hair. This study aims to analyze the content and toxicity of mercury (Hg) in biological samples such as blood, hair, urine and breast milk with various analytical methods including CV-AAS, AAS, CV-AFS, ICP-MS, FI-CV-AAS, and Mercury Analyzers. Data collection was based on the Literature Review by collecting several published research journals both at national and international levels which were filtered according to inclusion and exclusion criteria using the PRISMA method (Preferred Reporting Item for Systematic Review and Meta-Analysis). The method used depends on the needs of the analysis, its sensitivity and availability. Of the several methods used, AAS or atomic absorption spectrophotometry is the most commonly used method, because this method is simple and considered fast for analyzing mercury levels in biological samples.

Validasi Metode Analisis Senyawa Obat Dalam Sampel Biologis (Urine) Shinta Puspa Dwiyanti; Diva Afiah Hanifa Irawan; Zuyyinna Alya Abbas; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Urine is one of the selected specimens because the content of metabolites and drugs in urine is relatively high. In addition, the easiest and most stable sample to examine is a urine sample. The aim of this study was to determine a valid analytical method for analyzing drug compounds in biological samples of urine. The research method used was to conduct a literature study on several credible journals with journal criteria for the last 10 years regarding determining drug levels in human urine. The final results were obtained from five different analytes, namely Trimethoprim (TMP), ciprofloxacin, acetaminophen, methanol, and opiates which have been validated using several validation methods namely; HPLC with Photodiode Array Detector (PDA), HPLC with fluorescence detector, capillary electrophoresis with UV detector, spectrofluorometric, Gas Chromatography-Mass Spectrometry (GC-MS), GC-FID, and Spectro photo densitometry using human samples urine, all have met the validation requirements. So, it can be concluded that the biological sample of human urine is quite accurate as the sample used in the analytical validation method.

Co-Authors Diva Afiah Hanifa Irawan lina Nurfadhila Mochamad Galuh Ryandha Najla Yusiana Wahyudi Priscinya Christiana Debora Saarah Hamidah Asmara Indratno Shinta Puspa Dwiyanti Sofianti Hidayat Tiwi Ambarati Zuyyinna Alya Abbas

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