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All Journal YARSI Medical Journal Narra J Cermin Dunia Kedokteran Jurnal Penyakit Dalam Indonesia
Haerani Rasyid, Haerani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN MINYAK IKAN TERHADAP KONSENTRASI ASAM LEMAK DAN GEJALA KLINIS MALARIA Rasyid, Haerani; Suwandi, Danny
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.962 KB) | DOI: 10.33476/jky.v15i1.1003

Abstract

The aim of the study is to find out the effects of fish oil supplementation on fatty acids concentration (Eicosapentanoat Acid and Docosahexaenoat Acid), fever attacks and Dikke Drupple (DDR) interpretation of samples. This study was designed as ?A Randomized Double Blind Pretest and Post-test Controled Group?. Samples were divided into two groups, experiment group with fish oil suplementation (8% EPA, 35 DHA) and control group (placebo) for 8 weeks. This study was conducted in a malaria endemic, Kadaila village, subdistrict of Karossa, District of Mamuju in 2003. The result of the study showed significant increased concentration of EPA and DHA of the experiment group than the control group (p 0,05). The fever attack was significantly decreased (p 0,05) in experiment group than the control group, while DDR was not significantly different (p 0,05) between two groups.
Hubungan Obstructive Sleep Apnea dengan Hipertensi Rasyid, Haerani; Zatalia R., St. Rabiul
Cermin Dunia Kedokteran Vol 43, No 9 (2016): Kardiovaskuler
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.806 KB) | DOI: 10.55175/cdk.v43i9.862

Abstract

Hipertensi merupakan masalah kesehatan penting yang berdasarkan etiologinya dikelompokkan menjadi hipertensi primer dan hipertensi sekunder. Obstructive sleep apnea merupakan salah satu penyebab hipertensi sekunder. Sekitar 50% subjek dengan OSA menderita hipertensi, di lain pihak diperkirakan 30-40% subjek hipertensi menderita OSA. Obstructive sleep apnea merupakan suatu sindrom klinik dengan karakteristik episode berulang kejadian apnea dan hypopnea akibat sumbatan total atau parsial jalan napas atas selama tidur. Pengetahuan interaksi OSA dengan hipertensi, serta tatalaksana klinis yang baik untuk kedua penyakit tersebut akan dapat menurunkan risiko penyakit kardiovaskuler.Hypertension, based on its etiology is classified to primary hypertension and secondary hypertension. Obstructive sleep apnea is a cause of secondary hypertension. About 50% OSA patients are accompanied with hypertension, and about 30-40% hypertension patients are with OSA. Obstructive sleep apnea is a clinical syndrome which is characterized by recurrent episodes of apnea and hypopnea because of total or partial obstructive upper airway during sleep. Understanding interaction between OSA and hypertension and its clinical management could help reduce risk of cardiovascular disease.
Conn’s Syndrome Due to Adrenal Adenoma Rasyid, Haerani; Bakri, Syakib; Kasim, Hasyim; Hidayat, Andi Rahmat; Syarif, Syarif; Azis, Abd
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Conn’s syndrome is characterized by an increase in aldosterone level causes sodium retention and an increase in urine excretion of potassium. This syndrome is characterized by trias hypokalemia, hypertension, and metabolic alkalosis. This article discussed a case report of a patient with uncontrolled hypertension with neuromuscular symptoms caused by recurrent hypokalemia. After an evaluation of the imaging test, we found a left adrenal tumor then we performed unilateral adrenalectomy surgery. Histopathology examination from the excised tumor revealed the adrenal adenoma. After unilateral adrenalectomy, the patient showed clinical and laboratory improvement.
Green algae Caulerpa racemosa compounds as antiviral candidates for SARS-CoV-2: In silico study Tassakka, Asmi CMAR.; Iskandar, Israini W.; Juniyazaki, Andi BA.; Zaenab, St; Alam, Jamaluddin F.; Rasyid, Haerani; Kasmiati, Kasmiati; Sinurat, Ellya; Dwiany, Fenny M.; Martien, Ronni; Moore, Abigail M.
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.179

Abstract

Green algae (Caulerpa racemosa) are known to contain bioactive compounds which are hypothesized to have antiviral activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to analyze the anti-SARS-CoV-2 potential of compounds extracted from the green alga Caulerpa racemosa using in silico analysis. The extract was obtained through maceration with 96% ethanol and the compounds present in the extract were identified through gas chromatography-mass spectroscopy (GC-MS). The binding affinities were analyzed in silico using the PyRx application and visualized in the PyMOL software. GC-MS analysis of Caulerpa racemosa extract showed 92 spectral peaks, each of which was assigned to a bioactive compound. Of the six compounds with a strong binding affinity, n-[1-(1-adamantan-1-yl-propyl)-2,5-dioxo-4-trifluoromethyl-imidazo lidin-4-yl] 4-methoxy-benzamide had the lowest score (-8.1 kcal/mol) against the SARS-CoV-2 3C-like protease binding site, similar with that of remdesivir. The molecular dynamics calculations demonstrated that root means square deviation values of the selected inhibitors remained stable throughout a 15-nanosecond simulation. In conclusion, the in silico analysis suggests that Caulerpa racemosa extract is a potential antiviral candidate against SARS-CoV-2.
Co-Authors Alam, Jamaluddin F. Aman, A Makbul Andi Rahmat Hidayat, Andi Rahmat Azis, Abd Dwiany, Fenny M. Iskandar, Israini W. Juniyazaki, Andi BA. Kasim, Hasyim Kasmiati Kasmiati Martien, Ronni Moore, Abigail M. Patellongi, Ilham J Sinurat, Ellya Suwandi, Danny Syakib Bakri Syarif Syarif Tassakka, Asmi CMAR. Zaenab, St Zatalia R., St. Rabiul