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All Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Unri Conference Series: Community Engagement
Nur Aira Juwita
Universitas Sumatera Utara
Humanities Education

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Analisis Network Pharmacology Senyawa Metabolit Sekunder Tumbuhan Benalu Kopi (Loranthus ferrugineus Roxb.ex Jack Danser) pada Penyakit Kanker Payudara Nur Aira Juwita; Wawan Sujarwo; Dinda Rizka Manurung
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 4 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/gz2pdd34

Abstract

This study aims to evaluate the potential of coffee bean metabolite compounds as breast anticancer agents through a network pharmacology approach. The method used starts from literature study and PubChem database. Selection of compound eligibility was carried out with SwissADME using Lipinski's Rule of Five criteria. Protein target prediction was done through SwissTargetPrediction, while breast cancer target data was obtained from GeneCards and OMIM. Protein-protein interactions were analyzed with STRING and visualized using Cytoscape. Compound-protein interactions were analyzed through STITCH. The results showed that nine metabolite compounds from coffee bean met the pharmacokinetic criteria, with five main compounds showing anticancer potential is quercetin, oleic acid, linoleic acid, GCG, and PPARA. Protein interaction network analysis identified five central target proteins: IL6, TNF, AKT1, PTGS2, and ESR1. The compound-protein interactions suggest multitarget potential in the modulation of breast cancer-related molecular pathways. Keywords: Breast Cancer, Loranthus ferrugineus, Network Pharmacology
Peningkatan Skill Wirausaha Siswa Melalui Pembuatan Sabun Cair Bebas Alergen Mengandung Minyak Atsiri Limbah Kulit Jeruk Nipis Di SMA Labschool, Banda Aceh Poppy Anjelisa Zaitun Hasibuan; Muhammad Fauzan Lubis; Nurul Suci; Nur Aira Juwita; Didi Nurhadi Illian
Unri Conference Series: Community Engagement Vol 7 (2025): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.7.264-267

Abstract

Secondary school students' entrepreneurial competencies frequently remain confined to theoretical understanding without practical application in economically viable products. Concurrently, lime (Citrus aurantifolia) peel waste, containing valuable antibacterial essential oils, is often discarded without optimal utilization. This community engagement initiative aimed to enhance students' entrepreneurial capabilities through training in producing hypoallergenic liquid soap derived from lime peel essential oil. The intervention employed a Community Based Interactive Approach (CBIA) methodology, implemented through three distinct phases: pre-implementation, implementation, and monitoring and evaluation. Analytical results demonstrated that the formulated liquid soap exhibited dermatologically favorable properties including a pH range of 5.0-6.8, viscosity between 1100-1285 cP, and stable foam height maintenance (5.5-6.5 cm). The product demonstrated moderate antibacterial efficacy against Staphylococcus aureus (9.75 mm inhibition zone) and Escherichia coli (6.88 mm inhibition zone). Hedonic evaluation revealed exceptionally positive consumer acceptance, with ≥80% of panelists expressing preference for the product's aroma, chromatic characteristics, and textural properties. Irritation assessment confirmed the product's dermatological safety. Most significantly, participants exhibited a substantial 54.5% improvement in entrepreneurial comprehension, with mean evaluation scores increasing from 55 (pre-test) to 85 (post-test). This program successfully augmented students' entrepreneurial competencies while providing an innovative solution for repurposing organic waste into commercially viable products.
Co-Authors Didi Nurhadi Illian Dinda Rizka Manurung Hasibuan, Poppy Anjelisa Zaitun Muhammad Fauzan Lubis Nurul Suci Wawan Sujarwo