<![CDATA[In the education system in Indonesia in the 21st century, students are required to have 4C skills, namely, (1) communication; (2) collaboration; (3) critical thinking ability; (4) creativity and innovation. The ability to collaborate is one of the main competencies that students must acquire to meet the needs and skills in the world of work. This research is in the form of a systematic literature study that aims to obtain media information, methods, results, and problems in the application of collaborative learning in an educational environment. Literature was obtained through the Scopus database with a boolean operator search technique, then 1446 literatures found were then filtered for reporting items for a systematic review and meta-analysis approach (PRISMA) so that 33 literatures on 21st century skills were obtained. The results showed that the media used could be through LMS, software, and games as well as the most dominant method used is Problem Based Learning (PBL) with additional media innovation or other methods. The use of these media and methods has a positive impact on improving learning outcomes and collaboration skills, students also feel motivated and challenged by collaboration, including the use of online media was able to increase students' lower self-confidence to collaborate. However, collaborative learning has several problems including, (1) current students tend to be non-homogeneous so they tend not to be ready for collaboration; (2) educators do not clearly know the obstacles of students when conducting online collaborative learning; (3) students lack experience with projects so they are reluctant to work in groups; (4) distance collaborative learning is not enough to capture social signals than face-to-face; (5) learning media has not been fully able to improve 21st century skills and objectives; (6) measuring tools for collaborative skills do not yet have sufficient indicator.]]>
