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All Journal Jurnal Kedokteran Diponegoro Jurnal Muara Medika dan Psikologi Klinis
Frans Ferdinal
Tarumanagara University
Health Professions Medicine & Pharmacology Neuroscience

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UJI TOKSISITAS, AKTIVITAS ANTIOKSIDAN DAN KADAR METABOLIT SEKUNDER DAUN KEMANGI (Ocimum X africanum lour) Timotius Timotius; David Limanan; Frans Ferdinal
Jurnal Muara Medika dan Psikologi Klinis Vol. 1 No. 2 (2021): Jurnal Muara Medika dan Psikologi Klinis
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmmpk.v1i2.15308

Abstract

High pollutant level has caused an increase in disease that is correlated to Reactive Oxygen Species through a condition that is oxidative stress. Oxidative stress can be stabilized with antioxidants by stabilizing active and unstable radicals to become inactive and stable. Basil leaves (Ocimum x africanum lour) are known to posses antioxidant composition. The aim of this study is to determine the antioxidant ability and toxicity level of basil leaves. The research was conducted through an in vitro experimental study design and bioassays. Extraction of this research was carried out by maceration method using methanol as solvent. The tests were carried out in the form of antioxidant capacity tests using the 1,1-diphenyl-2-picrylhydrazyl method, toxicity tests using the brine shrimph lethality test method on Basil Leaf extract. In basil leaf extract, the antioxidant capacity test obtained IC50 of 174.04 ?g/mL, phenolic level test was 10872,92 mg/mL, alkaloid level test was 8.15 ?g/mL, toxicity test obtained LC50 of 158.36 ?g/mL. This study concludes that basil leaves contain antioxidants not as much as vitamin C however basil leaves do not have an effect that triggers an increase in stomach acid, so it has potential as an alternative antioxidant for a patient with stomach acid disorder, in addition, basil leaves also have cytotoxicity activity that is possible to be used as anti-carsinogen.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY ASSESSMENT OF YELLOW WOOD ROOT (ARCANGELISIA FLAVA (L.) MERR.) USING THE FRAP AND ABTS METHOD Maria Sheryll Oktaverlyn; Noer Saelan Tadjudin; Eny Yulianti; Frans Ferdinal
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 4 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i4.51703

Abstract

Background: Yellow wood root/ Arcangelisia flava, a traditional medicinal plant commonly used in Kalimantan, Indonesia, has been found to possess strong antioxidant properties. Although previous studies have reported that this plant contains certain phytochemicals and exhibits antioxidant activity, other specific phytochemical composition of the root and its antioxidant capacity using the FRAP and ABTS method remain poorly understood. Objective: This study aimed to examine the phytochemical content and antioxidant activity of the methanol extract from Arcangelisia flava (yellow wood) root. Methods: The research was conducted using an in vitro experimental approach to evaluate the presence of secondary metabolites and antioxidant capacity through the Ferric Reducing Antioxidant Power (FRAP) and 2,2′-azinobis-(3-ethylbenozothiazoline-6- sulfonate) (ABTS) assays. Extraction was performed on 75 grams of dried yellow wood root simplicia using methanol as the solvent, yielding 21.57 grams of extract (28.76%). Results: Phytochemical analysis detected a range of secondary metabolites including alkaloids, terpenoids, phenolics, quinones, saponins, tannins, coumarins, betacyanins, cardiac glycosides, flavonoids, and glycosides, while steroids and anthocyanins were not detected. The antioxidant activity was measured at extract concentrations of 10-30 μg/mL. In the FRAP assay, the extract reduced Fe³⁺ to Fe²⁺ with an IC₅₀ value of 17.48 μg/mL, while in the ABTS assay, it neutralized free radicals with an IC₅₀ of 21,99 μg/mL. Both results indicate a strong antioxidant potential and are comparable to the Trolox standards (IC₅₀ = 10.54 μg/mL and 13.27 μg/mL, respectively). Conclusion: These findings support the traditional use of Arcangelisia flava (L.) Merr., suggesting its potential as a source of natural antioxidants. Further research is recommended to explore its mechanisms and potential applications in health and disease prevention.
Co-Authors David Limanan Eny Yulianti Maria Sheryll Oktaverlyn Noer Saelan Tadjudin Timotius Timotius