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Yayat Sudaryat
Politeknik Kesehatan Kemenkes Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS EKSTRAK DAUN DAN BUAH BELIMBING WULUH (Averrhoa bilimbi) SEBAGAI ANTIDIABETES MELALUI INHIBISI α-AMILASE Mimin Kusmiyati; Yayat Sudaryat; Zuri Rismiarti; Elsa Dewita Sari
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 15 No 1 (2023): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v15i1.2118

Abstract

Diabetes mellitus is a group of disorders characterized by hyperglycemia. The leaves and fruit of Averrhoa bilimbi may be used to treat type 2 diabetes mellitus by inhibiting the action of the α-amylase enzyme. This research was conducted to determine the potential of Averrhoa bilimbi leaves and fruit extracts in inhibiting the action of the α amylase enzyme in vitro. The activity test of Averrhoa bilimbi leaves and fruit extract was carried out using the DNS method with 3 test groups, namely negative control (without sample or standard), positive control (acarbose), and test solution (extract of Averrhoa bilimbi leaves and fruit) with a concentration of 10 ppm , 15 ppm, 20 ppm, 25 ppm, and 30 ppm. The results obtained were expressed as IC50 values ​​sequentially for acarbose, leaves extract, and fruit extract, namely 32,0397 ppm, 30,2749 ppm, and 16,1616 ppm. data were analyzed by Post Hoc ANOVA test, which showed a significant difference between acarbose and Averrhoa bilimbi fruit extract (p < 0.05). It is concluded that the extract of both Averrhoa bilimbi leaves and fruit has anti-diabetes potential in vitro.
Co-Authors Elsa Dewita Sari Mimin Kusmiyati Zuri Rismiarti