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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Pandu Husada
Kartika Prahasanti
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Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Potensi Penggunaan Antagonis TRPV1(Transient Receptor Potential Vanilloid Type 1) Krim PAC-14028 Sebagai Terapi Dermatitis Atopik Tri Rosalia Nur Sholikah; yuli Wahyu Rahmawati; Kartika Prahasanti; Nenny Triastuti
JURNAL PANDU HUSADA Vol 2, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v2i2.6598

Abstract

Transient Receptor Potential Vanilloid type 1(TRPV1) adalah saluran kation nonselektif yang diaktifkan oleh berbagai rangsangan penghasil rasa sakit seperti capsaicin, perubahan pH dan panas. Diketahui kemungkinan bahwa TRPV1 berperan penting dalam terjadinya pruritus dan induksi inflamasi pada dermatitis atopik, sehingga Antagonis TRPV1 PAC-14028 dapat menjadi pilihan terapi potensial untuk pasien dermatitis atopik. Tujuan ditulisnya artikel ini untuk mengetahui potensi penggunaan antagonis TRPV1 krim PAC-14028 sebagai terapi pada dermatitis atopik. Artikel ini dibuat dengan meninjau jurnal penelitian dan artikel artikel ilmiah berdasarkan pencarian menggunakan PubMed, PMC, Google Scholar. Hasil penelitian menunjukkan Antagonis TRPV1 krim PAC-14028 dapat menekan gejala mirip dermatitis atopik dengan mempercepat pemulihan penghalang kulit. Sehingga dapat disimpulkan bahwa Krim PAC-14028 mempunyai potensi sebagai pengobatan pada dermatitis atopik.
The Relationship Between Degrees of Myopia and Intraocular Pressure at dr. Wahidin Sudirohusodo Mojokerto Hospital Rini Kusumawar Dhany; Tiara Alifiyah; Kartika Prahasanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.25598

Abstract

Myopia is a common refractive disorder, and its prevalence continues to rise globally, including in Indonesia. In young adults over 21 years of age, the prevalence of myopia with a refractive error greater than -0.5 D reaches 48.1%. Myopia has been associated with various ocular complications, including elevated intraocular pressure (IOP), which can lead to further vision impairment. This study aims to analyze the relationship between the degree of myopia and intraocular pressure in myopic patients. A cross-sectional and consecutive sampling of myopia patients at Dr. Wahidin Sudirohusodo Hospital. Data from medical records and direct examination. Chi square correlation analysis revealed a significant relationship between the degree of myopia and intraocular pressure. In the right eye, the p-value was 0.03 (p < 0.05), while in the left eye, it was 0.01 (p < 0.05). Patient characteristics showed that the majority were female (69.6%), and most patients were young adults aged 21–40 years (79.7%). There is a significant relationship between the degree of myopia and intraocular pressure at Dr. Wahidin Sudirohusodo hospital.
Pregnancy in women with thalassemia dependent transfusion: A case report on the importance of multidisciplinary surveillance to improve maternal and child safety Made Oka Heryana; Kris Gratia Ageng Nanda; Pradana Zaky Romadhon; Kartika Prahasanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.25951

Abstract

Thalasemia affects hemoglobin production. Transfusion-dependent thalassemia is a demanding clinical condition requiring lifelong care and follow-up. A 38-year-old woman is pregnant with her fourth child at 35 weeks gestation. This woman was diagnosed with Hb-E thalassemia-dependent transfusion (Hb electrophoresis showing Hb E 51.5%, Hb F 41.5%, and Hb A 3.5%). The Patient appeared pale with anemic conjunctiva, white sclera, and abdominal enlargement due to pregnancy. The Patient weighs 42 kg, and her height is 150 cm (BMI 18.67). Laboratory results were microcytic hypochromic anemia with hemoglobin 7.4 g/dL, erythrocytes 3.12 million/mL, mean cell volume (MCV) 74.0 fl, mean cell hemoglobin (MCH) 23.7 pg, mean cell hemoglobin (MCHC) 32 g/dL, and platelets with a platelet count of 133,000/µL. A cesarean method was chosen to terminate the pregnancy. There was no intrapartum and postpartum complication in this Patient. Her baby was 1.860 grams and 47 cm in length. There are no abnormalities found in the neonatal examination. Management of pregnant women with thalassemia requires special attention from preconception, during pregnancy, and toward delivery time. Multidisciplinary involvement such as hematologists and obstetricians is the primary key to the safety of mothers and children.
Co-Authors Kris Gratia Ageng Nanda Made Oka Heryana Nenny Triastuti Rini Kusumawar Dhany Romadhon, Pradana Zaky Tiara Alifiyah Tri Rosalia Nur Sholikah Yuli Wahyu Rahmawati, Yuli Wahyu