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All Journal Cerdika: Jurnal Ilmiah Indonesia
Adang Muhammad Gugun
Universitas Muhammadiyah Yogyakarta
Humanities Economics, Econometrics & Finance Education Health Professions Public Health Social Sciences

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DIFFERENCES IN S-RBD ANTIBODY TITERS OF SARS-CoV-2 POST-VACCINATION AND POST-COVID-19 IN UMY EMPLOYEES THAT DO GENERAL MEDICAL CHECK UP AT AMC MUHAMMADIYAH HOSPITAL YOGYAKARTA Suryanto Suryanto; Adang Muhammad Gugun
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 7 (2023): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v3i7.637

Abstract

COVID-19 is a global health problem today. Prevention is the best effort, including vaccination. The earliest evidence of the effectiveness of vaccination was marked by an increase in antibody levels. Research is needed to prove the effectiveness of vaccination by measuring levels of SARS-CoV-2 S-RBD antibodies and comparing them with individuals infected with COVID-19. This study aims to determine and prove differences in the levels of SARS-CoV-2 S-RBD antibodies in individuals with a history of COVID-19 vaccination in subjects who have been infected and who have not been infected with COVID-19. The type of research to be conducted is an analytic observational study with a cross sectional design. The variables studied were the levels of SARS-CoV-2 S-RBD antibodies in individuals who received the COVID-19 vaccination. Subjects consist of groups who have experienced infection and who have never been infected with COVID-19. The subjects used in this study were UMY employees who did general post-vaccination check-ups. The sampling technique used purposive sampling method with the inclusion criteria: (i) employees who are actively working (ii) Age 20-56 years (iii) There is a history of infection evidenced by PCR examination evidence (iv) getting vaccinated for more than 2 weeks. Exclusion criteria for employees who have a history of immune or autoimmune deficiency. This research was conducted at AMC Muhammadiyah Hospital. Examination of antibody levels of S-RBD SARS-CoV-2 was carried out using the Elisa method. Data analysis used descriptive method. The research subjects were 90, consisting of 45 subjects who had been exposed and 45 subjects who were not exposed to COVID-19. Subjects exposed to COVID-19 consisted of 25 men and 15 women, while subjects who were not exposed to COVID-19 consisted of 19 men and 26 women. The research subjects were 23 to 64 years old. From the results of the examination of S-RBD SARS-CoV-2 antibody levels, the results showed that the exposed group had a minimum level of 45.16 AU/mL while the maximum level was more than 1,000 AU/mL. In the unexposed group, 12 subjects had levels <3 AU/mL, while the rest had a minimum level of 3.01 AU/mL and a maximum level of 39.6 AU/mL. From this study, it can be concluded that there are differences in the levels of SARS-CoV-2 S-RBD antibodies which are higher in individuals who have been exposed to COVID-19 than individuals who have not been exposed. There are subjects who have not responded to the COVID-19 vaccination.
The Difference In Potassium Levels In Fresh Blood Bags With Blood Bags Stored At Pku Muhammadiyah Gamping Hospital Suryanto Suryanto; Adang Muhammad Gugun; Diah Nurpratami
Cerdika: Jurnal Ilmiah Indonesia Vol. 4 No. 2 (2024): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v4i2.758

Abstract

Blood transfusion, one of them, is a process of transferring blood components containing glucose, lactate, and potassium. During storage, blood cells undergo metabolic changes such as decreased blood pH, hemolysis, and increased potassium levels. One of the complications of transfusion that must be avoided is hyperkalemia due to the release of potassium. This study aimed to determine differences in stored blood potassium levels and PRC QC results during 11 days of storage. This was an analytic observational study with a cross sectional approach. A T-test was used to analyze the difference. In addition, PRC blood quality control (QC) was also carried out for stored blood according to standards. This study used 40 samples of fresh blood bags obtained from UTD PMI Yogyakarta City. The mean potassium level in fresh blood bags was 4.373 ± 0.417 mmol/L (3.70-5.50) and the average potassium level in blood bags stored for 6 days was 8.290 ± 0.275 mmol/L (7.80-8.90). There was a significant difference in potassium levels between fresh blood bags and blood bags stored for 6 days (p = 0.000). The overall QC PRC result is 50% which indicates the need for improvement in terms of the blood component separation process.
The Effect of Initial Anti-tuberculosis Drug Therapy on Transminase Enzymes Adang Muhammad Gugun; Suryanto Suryanto; Dyah Nova Ranti Ayuningtyas
Cerdika: Jurnal Ilmiah Indonesia Vol. 4 No. 03 (2024): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v4i03.762

Abstract

Tuberculosis is still a health problem in the world. TB treatment is carried out in 2 phases, namely early and advanced. This study aims to determine changes in serum transaminase enzyme levels (SGOT and SGPT) in pulmonary TB patients before and after initial drug administration. This study was observational with a cohort study design study. Observations were conducted in tuberculosis patients who received initial ATD therapy for 2 months for SGOT and SGPT enzyme levels before and after treatment. The subject of the study was a new case of a pulmonary TB patient aged ?16 years. Subjects received initial therapy in the form of isoniazid, rifampicin, pyrazinamide, and ethambutol. Recruitment of subjects through successive sampling methods with informed consent. Using a spectrophotometer, SGOT and SGPT enzyme tests were performed on the median blood serum cubital vein. Data analysis using the Wilcoxon Test. The study involved 19 subjects (10 men and 9 women) aged 16-65 years. Before ATD, the mean SGOT was 22.84 IU/L, and SGPT was 21.37 IU/L. After ATD, SGOT increased to 58.63 IU/L (p = 0.023), and SGPT to 80.84 IU/L (p = 0.007). Of the 19 subjects, 8 experienced a significant increase in SGOT and 5 SGPT. Five cases showed an increase in SGPT in line with SGOT, and 3 cases showed an increase in SGOT without SGPT. One case saw an increase in SGOT and SGPT of more than 5 times the reference value. This study confirms an increase in transaminase enzymes during initial therapy with first-line ATD.
Co-Authors Diah Nurpratami Dyah Nova Ranti Ayuningtyas Suryanto Suryanto