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Lupita Wijaya, Lupita
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Health Professions Medicine & Pharmacology Public Health

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Tatalaksana Nyeri Neuropatik Perifer dengan Sediaan Patch Wijaya, Lupita
Cermin Dunia Kedokteran Vol 48, No 9 (2021): Nyeri Neuropatik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.911 KB) | DOI: 10.55175/cdk.v48i9.1484

Abstract

Obat-obat oral seperti antidepresan trisiklik, antikonvulsan (gabapentin dan pregabalin), dan SSRI (selective serotonin reuptake inhibitors), masih menjadi pilihan pertama yang direkomendasikan oleh pedoman internasional dan Eropa untuk terapi nyeri neuropatik. Namun, penurunan nyeri hanya sebesar 30-40% dan sering disertai efek samping sistemik. Obat topikal sediaan patch menjadi salah satu terapi alternatif.Oral drugs like tricyclic antidepressant, anticonvulsants (gabapentin and pregabalin), and SSRI (selective serotonin reuptake inhibitors), still become first choice as recommended by international and Europe therapy guidelines for neuropathic pain. However, the regimen is effective in only about 30-40% cases and often has undesirable systemic adverse effects. Topical drugs in patch form can be one of alternative therapy for neuropathic pain.
Penatalaksanaan Terkini Penyakit Alzheimer Wijaya, Lupita
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.994 KB) | DOI: 10.55175/cdk.v46i1.544

Abstract

Alzheimer atau demensia merupakan suatu penyakit neurodegeneratif yang terjadi pada usia lanjut (65 tahun ke atas) berupa penurunan daya ingat akibat deposisi plak beta amiloid di dalam otak. Terapi yang diberikan saat ini seperti asetilkolinesterase, masih inadekuat karena tidak spesifik terhadap target terapi yakni plak beta amiloid. Diperlukan terapi baru yang bekerja langsung pada target.Alzheimer or dementia is a neurodegenerative disorder which often happened in the elderies (over 65 years old) with memory loss because of beta amyloid deposition in the brain. Current therapy such as acetylcholinesterase, still have inadequate response because that drug isn’t specific to therapeutic target, the beta amyloid plaque. A new therapy that acts directly to therapeutic target, is needed.
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