Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Odonto dental journal
Ririn Dwi Pratiwi
Gadjah Mada University
Health Professions Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Anxiolytic effect of aqueous extract of moringa oleifera in balb/c mice Ririn Dwi Pratiwi; Sri Kuswandari; Rinaldi Utomo
Odonto : Dental Journal Vol 10, No 1 (2023): July 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.1.1-6

Abstract

Background: Anxiety control is required to achieve successful dental treatment especially in children. Dental anxiety is exaggerated fear or worry associated with dental treatment and it is followed with a sense of losing control. Moringa oleifera has been claimed as a potential plant to treat anxiety. A large amount of flavonoid in Moringa oleifera leaves is known to have anxiolytic effect due to their interaction with gamma-aminobutyricacid (GABA) receptors like benzodiazepine molecule. The aim of this study was to determine the anxiolytic effect of aqueous extract of Moringa oleifera (AEMO) leaves in balb/c mice. Method: Subject of this study was 25 mice divided into 5 groups. Diazepam as a positive control (K+), CMC-Na 0.5% as a negative control (K-), aqueous extract of M. oleifera leaves 375 mg/kgBW (P1), 500 mg/kgBW (P2), and 625 mg/kgBW (P3). Tests were conducted using Elevated Plus Maze. Before and after data were analyzed with paired T-test, differences of anxiety score between groups was analyzed with One-way ANOVA. Result: Group P2 and P3 significantly reduce anxiety in mice (p
Co-Authors Rinaldi Utomo Sri Kuswandari