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Preeti Kothiyal, Preeti
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Medicine & Pharmacology

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Various approaches for targeting colon: a review Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

The colonic region of GIT has become an increasingly important site for drug delivery and absorption. This site specific delivery of drug to lower parts of the GIT is advantage for localized treatment of several colonic disease like colon cancer, crohn’s disease, ulceratice colitis, IBD, diarrhea etc. colon targeted drug delivery system (CTDDS) ensure direct treatment at the disease site and avoiding the systemic side effects. It is suitable for absorption site for protein and peptide drugs. Cytochrome P450 3A class of drug metabolizing enzyme, have lower activity in colon.  This review, mainly compares the primary approaches for (CTDDS) Colon targeted Drug Delivery system namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.
In-situ gel: a study of dental diseases Bisht, Neha; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

In-situ forming polymeric gelling systems has become prominent among novel drug delivery system (NDDS) in recent years due to advantages such as sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug in comparison to conventional drug delivery system (DDS). This is a type of mucoadhesive DDS where the polymeric formulation is in sol form before administration and once comes in contact with body fluids; it undergoes gelation to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. Conventional formulation for the treatment of dental diseases has certain drawbacks. A new concept of in situ gel was develop to overcome the shortcoming of conventional formulation which deals with dental diseases. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel.
Formulation and evaluation of colon targeted dosage form of prednisolone tablet using sterculia gum Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
Publisher : Creative Pharma Assent

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Abstract

Matrix tablets of Prednisolone were prepared by wet granulation method using various proportions of Sterculia gum with Carbopol 934P and Sterculia gum with Ethyl cellulose at 1:1, 1: .5 and 1:2 ratio. Coating was carried out by using 1:1 ratio of Eudragit L100 and Eudragit S100. All the preparation were evaluated for Pre compressional properties, Post compressional properties and in-vitro Dissolution study in different pH buffer of 0.1N HCL ,pH 7.4 , pH 6.8 in order to mimic GIT condition. Formulation shows good results with good percentage yield.
In-situ gel: a study of dental diseases Bisht, Neha; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.43 KB)

Abstract

In-situ forming polymeric gelling systems has become prominent among novel drug delivery system (NDDS) in recent years due to advantages such as sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug in comparison to conventional drug delivery system (DDS). This is a type of mucoadhesive DDS where the polymeric formulation is in sol form before administration and once comes in contact with body fluids; it undergoes gelation to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. Conventional formulation for the treatment of dental diseases has certain drawbacks. A new concept of in situ gel was develop to overcome the shortcoming of conventional formulation which deals with dental diseases. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel.
Various approaches for targeting colon: a review Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.671 KB)

Abstract

The colonic region of GIT has become an increasingly important site for drug delivery and absorption. This site specific delivery of drug to lower parts of the GIT is advantage for localized treatment of several colonic disease like colon cancer, crohn’s disease, ulceratice colitis, IBD, diarrhea etc. colon targeted drug delivery system (CTDDS) ensure direct treatment at the disease site and avoiding the systemic side effects. It is suitable for absorption site for protein and peptide drugs. Cytochrome P450 3A class of drug metabolizing enzyme, have lower activity in colon. This review, mainly compares the primary approaches for (CTDDS) Colon targeted Drug Delivery system namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process
Formulation and evaluation of colon targeted dosage form of prednisolone tablet using sterculia gum Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol. 2 No. 3 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.876 KB)

Abstract

Matrix tablets of Prednisolone were prepared by wet granulation method using various proportions of Sterculia gum with Carbopol 934P and Sterculia gum with Ethyl cellulose at 1:1, 1: .5 and 1:2 ratio. Coating was carried out by using 1:1 ratio of Eudragit L100 and Eudragit S100. All the preparation were evaluated for Pre compressional properties, Post compressional properties and in-vitro Dissolution study in different pH buffer of 0.1N HCL ,pH 7.4 , pH 6.8 in order to mimic GIT condition. Formulation shows good results with good percentage yield.
Co-Authors Laxmi Goswami, Laxmi Neha Bisht, Neha Neha Singh Raghuvanshi, Neha Singh