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D. S. Goswami, D. S.
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Medicine & Pharmacology

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Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug Goswami, D. S.; Uppal, N.
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.
Preparation and characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers Goswami, D. S.; Sharma, M.
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

Purpose of this research was to study mucoadhesive tablets of Amoxicillin trihydrate using Neem gum as mucoadhesive natural polymer. The conventional oral dosage form of this drug has low half life and high dosing frequency. Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Azadirachta indica as mucoadhesive polymer. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC K4M, carbopol 934P and sodium alginate) and natural (neem gum) polymers have been made to prepare total ten formulations. Further, different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing neem gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that neem gum is suitable for preparation of mucoadhesive tablets
Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug Goswami, D. S.; Uppal, N.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.
Co-Authors M. Sharma, M. N. Uppal, N.