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Pharmacological activities of pyrazolone derivatives Parajuli, Rishi Ram; Pokhrel, Priyanka; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Pyrazoline is a five member heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The review of the literature shows that the pyrazoline derivatives are quite stable and has inspired the chemists to synthesize the new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various pharmacological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc. and the pharmacological activities of different synthesized compound are reviewed in the present article.

Evaluation of phytochemical parameters, antibacterial and antihelminthic activity of leaves and bark extracts of plant Bombax ceiba Shah, Suyogya; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmonjoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol 5 No 3 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0006

Bombax ceiba, commonly known as the red silk-cotton tree, is a large, briefly deciduous tree occurring in warm monsoon forests in southern Asia. Various phytochemical constituents present in different plant parts has been already reported earlier to possess many biological activities, here in this work extraction was performed by mixture of solvent (distilled water: ethanol) as well as the individual solvents (water) and (ethanol). The phytochemical screening of the leaves and barks was found to exhibit the presence of carbohydrates, glycoside, saponin, phytosterol phenol, tannins, flavonoid, proteins and diterpenes and negative result for alkaloids in all the solvent extracts. The ethanolic extract of leaves was subjected to antihelmenthic activity and the result was found to be moderate.

A short glimpse on promising pharmacological effects of Begenia ciliata Pokhrel, Priyanka; Parajuli, Rishi Ram; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Bergenia ciliata is a potent indigenous folk medicine that has been proved fruitful in the treatment of various adverse conditions of the body. The major chemical constituents of plant include tannic acid, gallic acid, glucose, metarbin, albumen, bergenin, (+)-catechin, gallicin. Bergenia ciliata was subjected to bioactivity analysis. The plant has antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. It was observed that root and leaves extract were promising as antifungal agent. The root and leaves extract were effective against Microsporum canis, Pleuroetus oustreatus and Candida albicans.Â Â All the extracts except chloroform extract of root and leaves of Bergenia ciliata were found to possess hypoglycemic activity in Streptozotocin (STZ) treated rats. The methanolic extract exhibited significant anti-tussive activity in a dose-dependent manner. B. ciliata bear potent anti-neoplastic activities that may have prospective clinical use as precursor for preventive medicine. Methanolic and aqueous B. ciliata rhizome extracts were found to possess antioxidant activity, including reducing power, free radical scavenging activity and lipid peroxidation inhibition potential. Bergenia ciliata extracts exhibit a narrow spectrum antibacterial activity. The results obtained thus suggest that extracts of B. ciliata have promising therapeutic potential and could be considered as potential source for drug development by pharmaceutical industries.

Phytochemical screening, and antihelminthic activity of leaf and root extracts of Cassia tora plant Shrestha, Aashish; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmonjoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol 5 No 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0011

Cassia tora is one of the most important sources of medicinally important phytochemicals and widely used in Ayurvedic and Chinese system of medicine. The fresh plants of Cassia tora were collected from the different locality of Dharan, Sunsari district during the month of August. In this study leaves and root extracts were subjected to extraction by soxheletion by using ethanol and water and the extracts were subjected to antibacterial activity against Staphylococcus aureus and Citrobacter koseri. The ethanolic extracts were screened for antihelmenthic activity against Indian adult earth worm (Pheretima posthuma), with a moderate result. The result of antibacterial activity revealed that aqueous extract  of leaves and roots showed better activity in comparison to aqueous extracts particularly against gram positive bacteria (Staphylococcus aureus).

Pharmacological activities of pyrazolone derivatives Parajuli, Rishi Ram; Pokhrel, Priyanka; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.737 KB)

Pyrazoline is a five member heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The review of the literature shows that the pyrazoline derivatives are quite stable and has inspired the chemists to synthesize the new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various pharmacological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc. and the pharmacological activities of different synthesized compound are reviewed in the present article.

A short glimpse on promising pharmacological effects of Begenia ciliata Pokhrel, Priyanka; Parajuli, Rishi Ram; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.886 KB)

Bergenia ciliata is a potent indigenous folk medicine that has been proved fruitful in the treatment of various adverse conditions of the body. The major chemical constituents of plant include tannic acid, gallic acid, glucose, metarbin, albumen, bergenin, (+)-catechin, gallicin. Bergenia ciliata was subjected to bioactivity analysis. The plant has antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. It was observed that root and leaves extract were promising as antifungal agent. The root and leaves extract were effective against Microsporum canis, Pleuroetus oustreatus and Candida albicans. All the extracts except chloroform extract of root and leaves of Bergenia ciliata were found to possess hypoglycemic activity in Streptozotocin (STZ) treated rats. The methanolic extract exhibited significant anti-tussive activity in a dose-dependent manner. B. ciliata bear potent anti-neoplastic activities that may have prospective clinical use as precursor for preventive medicine. Methanolic and aqueous B. ciliata rhizome extracts were found to possess antioxidant activity, including reducing power, free radical scavenging activity and lipid peroxidation inhibition potential. Bergenia ciliata extracts exhibit a narrow spectrum antibacterial activity. The results obtained thus suggest that extracts of B. ciliata have promising therapeutic potential and could be considered as potential source for drug development by pharmaceutical industries.

Evaluation of phytochemical parameters, antibacterial and antihelminthic activity of leaves and bark extracts of plant Bombax ceiba Shah, Suyogya; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmajoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Bombax ceiba, commonly known as the red silk-cotton tree, is a large, briefly deciduous tree occurring in warm monsoon forests in southern Asia. Various phytochemical constituents present in different plant parts has been already reported earlier to possess many biological activities, here in this work extraction was performed by mixture of solvent (distilled water: ethanol) as well as the individual solvents (water) and (ethanol). The phytochemical screening of the leaves and barks was found to exhibit the presence of carbohydrates, glycoside, saponin, phytosterol phenol, tannins, flavonoid, proteins and diterpenes and negative result for alkaloids in all the solvent extracts. The ethanolic extract of leaves was subjected to antihelmenthic activity and the result was found to be moderate

Phytochemical screening and antihelminthic activity of leaf and root extracts of Cassia tora plant Shrestha, Aashish; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmajoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Cassia tora is one of the most important sources of medicinally important phytochemicals and widely used in Ayurvedic and Chinese system of medicine. The fresh plants of cassia tora were collected from the different locality of Dharan, Sunsari district during the month of August. In this study leaves and root extracts were subjected to extraction by soxheletion by using ethanol and water and the extracts were subjected to antibacterial activity against Staphylococcus aureus. and Citrobacter koseri, the ethanolic extracts were screened for antihelmenthic activity against Indian adult earth worm (Pheretima posthuma) with a moderate result. The result of antibacterial activity revealed that aqueous extract of leaves and roots showed better activity in comparison to aqueous extracts particularly against gram positive bacteria (Staphylococcus aureus).

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