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Yusra Pintaningrum
Interventional Cardiology Division, Cardiology and Vascular Department, Faculty of Medicine, Universitas Mataram, West Nusa Tenggara General Hospital, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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Hasil Tomografi Koherensi Optik Dibandingkan dengan Ultrasonografi Intravaskular untuk Memandu Intervensi Koroner Perkutan: Tinjauan Sistematis dan Analisis Meta dari Uji Coba Kontrol Acak Ketut Angga Aditya Putra Pramana; Ni Gusti Ayu Made Sintya Dwi Cahyani; Yusra Pintaningrum
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.4870

Abstract

In the recent years, the alternative intravascular imaging modalities that are most frequently employed to direct and optimize PCI have been intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The comparative effectiveness of OCT-guided vs IVUS-guided PCI is still up for debate. The purpose of this study was to conduct a systematic review and meta-analysis of all available studies comparing OCT-guided versus intravascular ultrasound (IVUS)-guided PCI. Electronic journals searching were performed in PubMed, ScienceDirect, and Cochrane from January 2015 to March 2023 to identify randomized control trial (RCT) studies that compare OCT‐guided PCI to IVUS‐guided PCI. Meta-analyses were performed on included studies and Odds ratio (OR) and 95% Confidence Interval (CI) were estimated using Review Manager v5.4. A total of four RCT enrolling 1316 participants were included in our analysis. There is no statistical significance was observed in the OCT versus IVUS comparison on all cause mortality [OR = 1.75, 95% CI (0.52, 5.88), p = 0.37], cardiovascular mortality [OR = 1.40, 95% CI (0.27, 7.11), p = 0.69], MACE [OR = 1.04, 95% CI (0.63, 1.71), p = 0.88], ST [OR = 0.94, 95% CI (0.16, 5.52), p = 0.95], TLR [OR = 0.77, 95% CI (0.39, 1.50), p = 0.44], and TVR [OR = 1.19, 95% CI (0.68, 2.07), p = 0.54].
Efikasi Terapi Empagliflozin pada Pasien Gagal Jantung Akut: Meta-analisis Yusra Pintaningrum; Komang Pranayoga
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5000

Abstract

Heart failure is still a common disorder with a high morbidity and mortality rate around the world. New drugs sodium-glucose cotransporter 2 inhibitors (SGLT2i) such as empagliflozin are currently showing promising results across the HF spectrum. Based on this, the authors are interested in researching the efficacy of Empaglifozin Therapy in Patient with Acute Heart Failure. This study used a systematic search using PRISMA principle in several online databases (Pubmed, Cochrane library and Google scholar). The selected study was an RCT or clinical trial with a population of Acute HF patients. The intervention group is Empagliflozin in any dose compared to placebo. The primary outcome for this meta-analysis is the levels of BNP or NT-proBNP and mortality after intervention. Selected study will be assessed and analyzed using Review Manager software version 5.3 with 95% CI. The two studies selected in this meta-analysis had a total sample size of 290 in the intervention group and 285 in the placebo group. Heterogenecity test obtained [p=0.44; I2 0%], indicating the homogenous data and the study is recommended to use the fixed effect method. The pooled effect size of RR is 0.472 [CI95% 0.24-0.75, P=0.003], meaning that there is a significant favorable outcome in empagliflozin group than in the placebo group. The results showed that empagliflozin had shown a favorable effect in reduction of the risk of death and reducing level of NT-proBNP in patient with acute heart failure.
Co-Authors Ketut Angga Aditya Putra Pramana Komang Pranayoga Ni Gusti Ayu Made Sintya Dwi Cahyani