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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Melody Nethania Sutedja
Department of Obstetrics and Gynecology, Mariano Marcos Memorial Hospital and Medical Center, Ilocos Norte, Philippines
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Comparative Efficacy of Endometrial Biopsy using Pipelle and Diagnostic Dilatation & Curettage in Mariano Marcos Memorial Hospital and Medical Center Melody Nethania Sutedja; Ruth Judith Gay V. Cristobal; Maria Constancia Celina C. Ferraris; Czarina Juliana L. Alcaraz; Gisele V. Gonzales-Acantilado
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.871

Abstract

Background: The use of Pipelle sampling for endometrial histology and pathology is of some controversy - and vast importance. Pipelle procedures are performed commonly in medical offices when women show abnormal vaginal bleeding. While the method has several advantages over dilatation and curettage (D&C), clinical questions exist on the precision and accuracy of the procedure. This study aimed to assess the effectiveness of Pipelle biopsy sampling versus Dilatation & Curettage (D&C) in adequacy of sampling specimen in terms of cost effectiveness, diagnosis success rate, sensitivity, specificity, positive predictive value, and negative predictive value. Methods: A retrospective study was conducted among all enrolled women with abnormal uterine bleeding counselling outpatient and inpatient in MMMHMC Batac from 2016 to 2017. Sample was divided in two groups - those that underwent Pipelle biopsy and those who underwent D&C. Key statistics were computed using SPSS 16. Results: Cost effectiveness analysis showed that Pipelle biopsy offers a more cost effective alternative with an estimate of one correct diagnosis every P16 spent versus P61 spent for a correct diagnosis using D&C. Both procedures resulted in a 100% likelihood ratio of having the condition with a positive test result, with D&C resulting in a higher diagnosis success rate of 98% (versus 92% for Pipelle) and higher proportion of those who have the disorder, given the procedure tested positive. Conclusion: Pipelle biopsy offers a more cost effective alternative to D&C. Both procedures resulted in equal probability of having the condition with a positive test result, with D&C resulting in a higher success rate of diagnosis and sensitivity rate, albeit not statistically significant.
Mayer-Rokitansky-Kuster-Hauser Syndrome with Hyperandrogenemia: A Rare Case of Mullerian Dysgenesis Melody Nethania Sutedja; Florely Joy Estrera-Gregorio
Archives of The Medicine and Case Reports Vol. 4 No. 4 (2023): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v4i4.399

Abstract

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome with hyperandrogenism is a variety of Müllerian duct anomalies categorized by congenital aplasia of uterus and upper part two third of the vagina usually associated with uncommonly high level of testosterone. The MRKH affects 1 out of 4500 women and it is the most common causes of primary amenorrhea, however there are only 4 cases reported of MRKH syndrome with hyperandrogenemia in literature2. The MRKH syndrome usually remains asymptomatic up until the patient complains with primary amenorrhea nonetheless with normal secondary sexual physical development. We reported a case of a 21-year-old female with MRKH syndrome with hyperandrogenism who presented with primary amenorrhea, physical examination include tanner stage 5 breasts, short vaginal canal, pubic hair stage 4 with absence of cervix, and no clitoromegaly. Transvaginal ultrasound shows an infantile uterus while MRI shows small uterus with inactive endometrium with an incidental findings of Tarlov cyst. Counseling, assurance and supportive psychotherapy were given to the patient. Follicle stimulating hormone, chest X-ray, 75 gram oral glucose tolerance test, BUN, creatinine, audiogram and electrocardiogram results were reported with normal ranges. Chromosomal analysis was 46 XX karyotype. Serum testosterone was markedly elevated at 11.1 nmol/L, above the normal values for female.
The Comparative Efficacy of Endometrial Biopsy using Pipelle and Diagnostic Dilatation & Curettage in Mariano Marcos Memorial Hospital and Medical Center Melody Nethania Sutedja; Ruth Judith Gay V. Cristobal; Maria Constancia Celina C. Ferraris; Czarina Juliana L. Alcaraz; Gisele V. Gonzales-Acantilado
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.871

Abstract

Background: The use of Pipelle sampling for endometrial histology and pathology is of some controversy - and vast importance. Pipelle procedures are performed commonly in medical offices when women show abnormal vaginal bleeding. While the method has several advantages over dilatation and curettage (D&C), clinical questions exist on the precision and accuracy of the procedure. This study aimed to assess the effectiveness of Pipelle biopsy sampling versus Dilatation & Curettage (D&C) in adequacy of sampling specimen in terms of cost effectiveness, diagnosis success rate, sensitivity, specificity, positive predictive value, and negative predictive value. Methods: A retrospective study was conducted among all enrolled women with abnormal uterine bleeding counselling outpatient and inpatient in MMMHMC Batac from 2016 to 2017. Sample was divided in two groups - those that underwent Pipelle biopsy and those who underwent D&C. Key statistics were computed using SPSS 16. Results: Cost effectiveness analysis showed that Pipelle biopsy offers a more cost effective alternative with an estimate of one correct diagnosis every P16 spent versus P61 spent for a correct diagnosis using D&C. Both procedures resulted in a 100% likelihood ratio of having the condition with a positive test result, with D&C resulting in a higher diagnosis success rate of 98% (versus 92% for Pipelle) and higher proportion of those who have the disorder, given the procedure tested positive. Conclusion: Pipelle biopsy offers a more cost effective alternative to D&C. Both procedures resulted in equal probability of having the condition with a positive test result, with D&C resulting in a higher success rate of diagnosis and sensitivity rate, albeit not statistically significant.
Co-Authors Czarina Juliana L. Alcaraz Florely Joy Estrera-Gregorio Gisele V. Gonzales-Acantilado Maria Constancia Celina C. Ferraris Ruth Judith Gay V. Cristobal