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All Journal Sriwijaya Journal of Surgery
Mulawan Umar
Oncology Unit, Surgery Department of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Medicine & Pharmacology

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Platelet/Lymphocyte Ratio Accuracy as Predictor of Neo-Adjuvant Chemotherapy Response in Locally Advanced Breast Cancer at Dr. Mohammad Hoesin General Hospital Palembang Abdur Rahman; Mulawan Umar; Erial Bahar
Sriwijaya Journal of Surgery Vol. 4 No. 1 (2021): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v4i1.54

Abstract

Background: Platelet/lymphocyte ratio (PLR) is considered as predictor for chemotherapy response in locally advanced breast cancer undergoing neo-adjuvant chemotherapy. This study aims to evaluate the relationship between the platelet/lymphocyte ratio and neo-adjuvant chemotherapy response in patients with locally advanced breast cancer at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study is a prognostic test of the platelet/lymphocyte ratio accuracy to predict the response of neo-adjuvant chemotherapy in patients with locally advanced breast cancer. The study included 113 subjects. Results: From 113 patients, the PLR cut off point value was 206.83 with an under curve area (AUC) of 91.8%. The results of the PLR prognostic test were sensitivity of 98%, specificity of 87%, Positive Predictive Value of 95%, Negative Predictive Value of 93%, and 95% of accuracy. There was a significant relationship between PLR and chemotherapy response in patients with locally advanced breast cancer (p = 0.000). Conclusion: There was a significant relationship between PLR on chemotherapy response. PLR can be used as a predictor of neo-adjuvant chemotherapy response with a good degree of accuracy.
Association between Ki67 After Neoadjuvant Chemotherapy and Disease-Free Survival in Breast Cancer Aan Setiawan; Mulawan Umar; Erial Bahar
Sriwijaya Journal of Surgery Vol. 4 No. 2 (2021): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v4i2.57

Abstract

Background: Post Chemotherapy Ki67 in recent year has been investigated as a predictive and prognostic factor in locally advanced breast cancer patient undergoing neoadjuvant chemotherapy. Objectives: To describe the relationship between post-chemotherapy Ki67 and disease-free survival after neoadjuvant chemotherapy in patients with locally advanced breast cancer at Dr. Hospital. Mohammad Hoesin Palembang. Methods: This study is an analytical observational study with prognostic test design conducted in 30 stage III B breast cancer patient. A retrospective search of a prospectively maintained clinical database was performed to identify patient treated with neoadjuvant chemotherapy at the Mohammad Hoesin Hospital. The expression of Ki67 was assessed using immunohisto-chemistry in post therapy surgical excision specimen. Results: From 30 patients, there was a significant relationship between Post Chemotherapy Ki67 and disease- free survival in patients with locally advanced breast cancer (r = -0,742, p = 0.000). The cut off point value of Ki67 was 27,5% with an area under curve (AUC) of 0,716. The results of the post-chemotherapy Ki67 prognosis test included sensitivity 64%, specificity 60%, Positive Predictive Value 88,9%, Negative Predictive Value 25%, accuracy 63,3%. Conclusion: There is a significant relationship between Post Chemotherapy Ki67 to disease free survival and Post Chemotherapy Ki67 can be used as a prognostic biomarker in breast carcinoma patients undergoing neoadjuvant chemotherapy.
Co-Authors Aan Setiawan Abdur Rahman Erial Bahar Erial Bahar