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All Journal Acta Biochimica Indonesiana Jurnal Integrasi Kesehatan dan Sains
Mirasari Putri
Department Of Biochemistry, Nutrition And Biomelecular, Faculty Of Medicine Universitas Islam Bandung, Bandung-Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Zinc deficiency effect on clinical features of Coronavirus Disease 2019 patients: A scoping review Moch Ikhsan Juliansyah; Lisa Adhia Garina; Mirasari Putri
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.123

Abstract

COVID-19 was declared a pandemic in March 2020. Various therapeutic guidelines have been established for treating COVID-19, such as anti-inflammatory, antiviral therapies, and zinc supplementation. Zinc deficiency is thought to worsen the condition of patients with COVID-19 infection. However, the effect of zinc deficiency on COVID-19 patients has not been widely reported. In this scoping review, we aim to explore the impact of zinc deficiency on the clinical features of COVID-19 patients. A comprehensive search was conducted across the databases, including PubMed, ScienceDirect, Springer Link, ProQuest, and Google Scholar, using the keywords “Zinc” AND “(COVID-19 or SARS-CoV-2)”. A total of 2,458 articles published between 2019 and 2020 were screened following the PRISMA guidelines and subjected to critical appraisal. Three articles were included, focusing on the effect of zinc deficiency on the clinical features of COVID-19 patients. As of 2022, two articles reported worsening symptoms, one described an increased hospitalization duration, and one reported worsening treatment outcomes in the zinc deficiency group. This review concludes that zinc deficiency worsens symptoms, increases the duration of hospitalization, and leads to worse outcomes in COVID-19 patients.
Pengaruh Kadar Feritin Darah terhadap Status Gizi Pasien Thalasemia β Mayor Anak Namira Ramadanty; Tito Gunantara; Mirasari Putri
Jurnal Integrasi Kesehatan dan Sains Vol 5, No 2 (2023): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v5i2.11677

Abstract

AbstrakThalasemia merupakan kelainan hemolitik yang ditandai dengan penghancuran sel darah merah secara berlebihan. Penyakit ini diwariskan secara autosomal resesif dari orangtua yang berakibat pada kelainan sintesis rantai globin. Pasien thalasemia menjalani pengobatan dengan transfusi darah setiap bulan selama hidupnya. Pengobatan tersebut menimbulkan efek samping yang signifikan terhadap tubuh pasien. Transfusi darah yang terus menerus dapat menyebabkan penimbunan zat besi sehingga kadar feritin dalam tubuh meningkat. Selain itu, pasien thalasemia berisiko mengalami gangguan kelenjar endokrin dan anemia. Kondisi tersebut menyebabkan anak menjadi tidak mempunyai nafsu makan sehingga asupan gizi bekurang. Penelitian ini dilaksanakan di RSUD Al-Ihsan Januari–Desember 2022. Tujuan penelitian ini adalah mengetahui pengaruh kadar feritin darah terhadap status gizi pasien thalasemia β mayor anak. Metode penelitian ini, yaitu observasional analitik melalui pendekatan cross sectional. Subjek penelitian ini berjumlah 58 orang. Alat yang digunakan pada penelitian adalah grafik pertumbuhan berdasarkan The WHO Reference 2007. Hasil studi menunjukkan p=0,004 (p<0.05) dengan nilai r sebesar 0,536 yang berarti terdapat pengaruh kadar feritin terhadap status gizi pasien thalasemia β mayor anak di RSUD Al-Ihsan Kabupaten Bandung tahun 2022. Simpulan, kadar feritin darah berpengaruh terhadap status gizi pasien thalasemia β mayor anak. Effect of Blood Ferritin Levels on Nutritional Status of Pediatric Patients with Thalassemia β MajorAbstractThalassemia is a hemolytic disorder characterized by excessive destruction of red blood cells. The disease is inherited autosomal recessive from the elderly resulting in abnormalities in the synthesis of globin chains. The thalassemia patient undergoes treatment with blood transfusions every month during his lifetime. Such treatment causes significant side effects to the patient's body. Continuous blood transfusions can cause iron accumulation so that ferritin levels in the body increase. In addition, thalassemia patients are at risk of endocrine gland disorders and anemia. This condition causes the child to have no appetite, so the nutritional intake is frozen. This research was conducted at Al-Ihsan Hospital January-December 2022. This study aimed to determine the effect of ferritin levels on the nutritional status of children with β thalassemia major. This research method is analytically observational through a cross-sectional approach. The subjects of this study amounted to 58 people. The tool used in this study was a growth chart based on the 2007 WHO Reference. The analysis results showed p= 0.004 (p-value<0.05) and r value of 0.536, which means that there is an effect of ferritin levels on nutritional status of pediatric patients with thalassemia β major at Al-Ihsan Hospital, Bandung Regency in 2022. This study concludes that ferritin levels affect the nutritional status of children with β thalassemia major.
Co-Authors Lisa Adhia Garina Moch Ikhsan Juliansyah Namira Ramadanty Tito Gunantara