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Hillda Herawati
Department of Orthodontics, Faculty of Dentistry, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Dentistry

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THE EFFECT OF KATUK LEAF GEL EXTRACT AS AN ANTI-INFLAMMATORY ORTHODONTIC TREATMENT ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS Hillda Herawati; Marlin Himawati; Diffa Nisa Nurfadillah
Journal of Health and Dental Sciences Vol. 3 No. 2 (2023): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

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Katuk leaf herbal plants can be used as an anti-inflammatory drug because these contain flavonoids which be able to reduce inflammation by inhibiting cyclooxygenase enzyme formation. Katuk leaf extract is made in gel form at a 78.3 mg/kg BW dose. The gel is one of the medicinal preparations with good dispersion and longer adherence ability compared to ointments and creams. The study aimed to determine the effect of Katuk leaf extract gel as an anti-inflammatory orthodontic treatment against carrageenan-induced rat leg edema. This type of laboratory experimental research used a posttest-only control group design. This study used Katuk leaf extract gel in the treatment group and base gel for the control group, which was repeated 16 times in Wistar rat test animals in each group. The Independent variable is gel leaf Katuk extract, and volume-bound swelling on the soles of rats' feet is the dependent variable—univariate and bivariate data analysis with the Mann-Whitney test. The study showed no significant difference in the average edema between the control and treatment groups; Katuk leaf extract gel had no effect on an edema volume (p-value=0.12) compared to the control group. The conclusion is that Katuk leaf extract gel does not reduce swollen volume compared to Na-CMC 0.5%. DOI : 10.54052/jhds.v3n2.p135-146
EFFECT OF ETHANOL EXTRACT OF KATUK LEAVES (Sauropus androgynus) ON MALONDIALDEHYDE LEVELS AS AN ANTIOXIDANT Hillda Herawati; Nabila Shafira Oktaviana; Iis Inayati Rakhmat
Journal of Health and Dental Sciences Vol. 5 No. 3 (2026): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

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The tooth movement that occurs when mechanical forces are applied to an orthodontic appliance can cause irritation and inflammation. This inflammation can contribute to increased oxidative stress in the oral cavity. The formation of oxidative stress can turn into a chain reaction that can continue to form new free radicals. Katuk leaves (Sauropus androgynus L. Merr) have antioxidant content that can slow down the process of free radicals. The purpose of this study was to determine the effect of the ethanol extract of katuk leaves as an antioxidant on reducing blood plasma MDA levels. The research method is a laboratory experiment using four treatment groups: blood plasma as a negative control, plasma oxidized with CuCl2 as a positive control, blood plasma given CuCl2, and ethanol extract of katuk leaves and plasma given CuCl2, and vitamin C as an antioxidant control. MDA levels were examined using the thiobarbituric acid reactive substance (TBARs) method. The data were analyzed by Anova and Tukey (p<0.05). The results showed that there was an effect of the ethanol extract of katuk leaves on malondialdehyde levels (p = 0.035) with MDA values of CuCl2 plasma (0.005 mg/dL), plasma with katuk (0.003 mg/dL), and plasma with vitamin C (0.021 mg/dL). It can be concluded that the use of ethanol extract from katuk leaves has antioxidant potential to decrease MDA levels in blood plasma. DOI : 10.54052/jhds.v5n3.p311-320
Co-Authors Diffa Nisa Nurfadillah Iis Inayati Rakhmat Marlin Himawati Nabila Shafira Oktaviana