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All Journal GIZI INDONESIA Jurnal Kefarmasian Indonesia Multidisciplinary Indonesian Center Journal
Hana Apsari Pawestri, Hana Apsari
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Religion Humanities Chemistry Earth & Planetary Sciences Education Medicine & Pharmacology Public Health Other

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THE OBESE MAN TO OBESE YEAST Pawestri, Hana Apsari; Trubenová, Barbora
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.682 KB)

Abstract

OBESITAS MOLEKULER PADA MANUSIA, AVERTEBRATA, DAN KHAMIRDalam beberapa tahun terakhir, obesitas telah menjadi salah satu masalah kesehatan utama di negara maju, dengan Amerika Serikat ada di urutan teratas. Meskipun terjadi perbaikan besar pada faktor sanitasi, perawatan kebidanan dan vaksinasi, tetapi usia harapan hidup menurun seiring dengan meningkatnya obesitas. Saat ini, obesitas merupakan epidemi global yang memengaruhi orang dewasa dan anak-anak, dan secara signifikan berhubungan dengan morbiditas dan mortalitas. Epidemi ini disebabkan oleh pergeseran besar penduduk ke pusat-pusat perkotaan, keterlibatan dalam pekerjaan dan aktivitas hidup santai, serta berlimpahnya makanan olahan padat-energi. Gaya hidup modern yang dianut oleh mayoritas penduduk di perkotaan sulit untuk mengurangi obesitas secara signifikan sehingga diperlukan upaya lain seperti terapi secara farmakokinetis dan pemahaman lebih dalam untuk mengendalikan nafsu makan dan asupan makanan. Gaya hidup dan faktor keturunan berperan penting terhadap timbulnya obesitas. Penelitian terhadap mutasi genetika pada manusia dan model organisme memberikan dasar-dasar wawasan tentang proses fisiologis kompleks dalam penguraian metabolisme lemak. Penelitian terbaru dari khamir Saccharomyces cerevisiae, cacing Caenorhabditis elegans, lalat buah Drosophila melanogaster dan ikan zebra Danio rerio menunjukkan bahwa organisme tingkat rendah seperti metazoa memiliki atribut unik yang dapat membantu mengidentifikasi, menyelidiki, bahkan memvalidasi target baru dalam dunia farmasi untuk penyakit-penyakit yang berhubungan dengan metabolisme.Kata kunci: obesitas, keturunan, penyakit metabolik
Deteksi Resistensi Oseltamivir Influenza A (H1N1pdm09) dari Pasien Infeksi Saluran Pernafasan Akut Berat di Indonesia tahun 2014 Setiawaty, Vivi; Pawestri, Hana Apsari; Susilarini, Ni Ketut
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 1, FEBRUARI 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i1.2912

Abstract

Influenza viruses are classified into subtypes based on two surface antigens known as hemagglutinin (HA) and neuraminidase (NA). Antigenic changes of influenza virus can cause resistance to antiviral drugs which is already limited in variation. Resistance to the drugs used recently are due to antigenic drift by point mutation in a single amino acid at position 275 (H275Y). The purpose of this research is to identify the presence of influenza virus A (H1N1pdm09) that were resistant to oseltamivir from cases of severe acute respiratory infection (SARI)in Indonesia in 2014 by using a rapid detection test. Detection of oseltamivir resistance in NA gene is to identify the single nucleotide polimorphism (SNP) at position 275 (H275Y) using the real-time RT-PCR method from clinical specimens SARI case. A total of 870 specimens from six sentinel hospitals were collected and 15 of them positive H1N1pdm09. Of the 15 clinical specimens, H1N1pdm09 virus strains that have mutations H275Y were not found. Based on this finding, it can be concluded that during the year 2014, there is no influenza virus A (H1N1pdm09) resistant to oseltamivir from SARI cases specimen in six sentinel hospitals in Indonesia.
CERTIFIED PCR TRAINING AS AN INNOVATIVE PROGRAM FOR ENHANCING THE COMPETENCE OF HEALTH LABORATORY HUMAN RESOURCES Pawestri, Hana Apsari; Nugraha, Arie Ardiansyah; Anggia, Markus Evan; Rizki, Aulia; Fithriani, Fithriani; Naibaho, Sauma Intan; Octaviani, Selly; Sariadji, Kambang; Subangkit, Subangkit; Handoko, Darmawali; Budiyanto, Budiyanto
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 3 No. 2 (2026): Vol. 3 No. 2 Edisi April 2026
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v3i2.2309

Abstract

The increasing threat of emerging and re-emerging infectious diseases necessitates the strengthening of the capacity of the Health Laboratory (Labkes) network, including Public Health Laboratories (Labkesmas), through the availability of competent and standardized laboratory human resources (HR). Polymerase Chain Reaction (PCR) testing has become the primary diagnostic method for pathogen detection, both in routine services and in public health emergency situations. The development of a PCR training curriculum and modules by the Center for Health Biology Laboratory (BBLBK) represents a strategic step toward standardizing the competencies of laboratory personnel. This article aims to describe the urgency of implementing certified PCR training policies as part of a national system for enhancing the competence of health laboratory human resources. The writing method employs policy analysis based on document review and the framework of national health regulations. The analysis results indicate variations in laboratory personnel competencies, the absence of a national certification scheme, limited availability of trainers, and the need for continuous curriculum updating. Certified PCR training is therefore recommended as a national instrument for fulfilling competency standards in health laboratories. The integration of training into the health human resource development system, along with the strengthening of quality- and safety-based approaches, is key to the successful implementation of this policy.
Co-Authors Anggia, Markus Evan Arie Ardiansyah Nugraha, Arie Ardiansyah Budiyanto Budiyanto Fithriani Gade Handoko, Darmawali Kambang Sariadji Naibaho, Sauma Intan Ni Ketut Susilarini Octaviani, Selly Rizki, Aulia Subangkit Subangkit Trubenová, Barbora Vivi Setiawaty