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Lissa Sabrina
Mitra Keluarga Hospital Kemayoran
Health Professions Medicine & Pharmacology Public Health

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Hyponatremia Induced by Amlodipine Lissa Sabrina; Sidharta Salim
Cermin Dunia Kedokteran Vol 50 No 9 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.874

Abstract

Introduction: Hyponatremia (<135 mmol/L) is one of the most common electrolyte disturbances in clinical practice. Correct treatment can prevent worse outcomes. A case of hyponatremia supposedly induced by amlodipine besylate was presented. Case: A 74 year-old male with lethargy and occasional nausea and admitted to having chronic hyponatremia in the past years. He’s been taking clopidogrel, simvastatin, and amlodipine besylate regularly since 7 years ago and had a history of coronary angioplasty 7 years ago. His lowest serum sodium level was 128 mmol/L even though he already took a 500 mg of sodium chlorine once daily. His serum sodium level never reached the normal range despite increasing salt intake and fluid restriction. Discontinuation of amlodipine besylate and change to nebivolol result in increased serum sodium level to 131 mmol/L. Conclusion: This case of hyponatremia may be induced by amlodipine.    Pendahuluan: Hiponatremia (<135 mmol/L) adalah salah satu gangguan elektrolit yang paling umum dalam praktik klinis sehari-hari. Tata laksana yang tepat dapat mencegah prognosis lebih buruk. Laporan ini memaparkan kasus hiponatremia diduga disebabkan oleh amlodipine besylate. Kasus: Laki-laki berusia 74 tahun datang dengan lesu dan mual sesekali dan mengaku menderita hiponatremia kronis dalam beberapa tahun terakhir. Dia telah mengonsumsi clopidogrel, simvastatin, dan amlodipine besylate secara teratur sejak 7 tahun yang lalu dan memiliki riwayat angioplasti koroner 7 tahun yang lalu. Kadar natrium serum terendahnya adalah 128 mmol/L, meskipun sudah mengonsumsi kapsul natrium klorida 500 mg sekali sehari. Kadar natrium serumnya tidak pernah mencapai kisaran normal, meskipun asupan garam dan pembatasan cairan sudah ditingkatkan. Amlodipine besylate dihentikan dan diganti dengan nebivolol; setelah itu kadar natrium serum menjadi 131 mmol/L. Simpulan: Kasus hiponatremia ini mungkin diinduksi oleh amlodipine.
Hyponatremia Induced by Amlodipine Lissa Sabrina; Sidharta Salim
Cermin Dunia Kedokteran Vol 50 No 9 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.874

Abstract

Introduction: Hyponatremia (<135 mmol/L) is one of the most common electrolyte disturbances in clinical practice. Correct treatment can prevent worse outcomes. A case of hyponatremia supposedly induced by amlodipine besylate was presented. Case: A 74 year-old male with lethargy and occasional nausea and admitted to having chronic hyponatremia in the past years. He’s been taking clopidogrel, simvastatin, and amlodipine besylate regularly since 7 years ago and had a history of coronary angioplasty 7 years ago. His lowest serum sodium level was 128 mmol/L even though he already took a 500 mg of sodium chlorine once daily. His serum sodium level never reached the normal range despite increasing salt intake and fluid restriction. Discontinuation of amlodipine besylate and change to nebivolol result in increased serum sodium level to 131 mmol/L. Conclusion: This case of hyponatremia may be induced by amlodipine.    Pendahuluan: Hiponatremia (<135 mmol/L) adalah salah satu gangguan elektrolit yang paling umum dalam praktik klinis sehari-hari. Tata laksana yang tepat dapat mencegah prognosis lebih buruk. Laporan ini memaparkan kasus hiponatremia diduga disebabkan oleh amlodipine besylate. Kasus: Laki-laki berusia 74 tahun datang dengan lesu dan mual sesekali dan mengaku menderita hiponatremia kronis dalam beberapa tahun terakhir. Dia telah mengonsumsi clopidogrel, simvastatin, dan amlodipine besylate secara teratur sejak 7 tahun yang lalu dan memiliki riwayat angioplasti koroner 7 tahun yang lalu. Kadar natrium serum terendahnya adalah 128 mmol/L, meskipun sudah mengonsumsi kapsul natrium klorida 500 mg sekali sehari. Kadar natrium serumnya tidak pernah mencapai kisaran normal, meskipun asupan garam dan pembatasan cairan sudah ditingkatkan. Amlodipine besylate dihentikan dan diganti dengan nebivolol; setelah itu kadar natrium serum menjadi 131 mmol/L. Simpulan: Kasus hiponatremia ini mungkin diinduksi oleh amlodipine.
Fanconi Syndrome and Osteomalacia Induced by Tenofovir Lissa Sabrina; Sidharta Salim
Cermin Dunia Kedokteran Vol 51 No 4 (2024): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i4.875

Abstract

Introduction: Tenofovir disoproxil fumarate (TDF), an antiviral nucleoside analog reverse transcriptase inhibitor, has been used for the treatment of HIV and HBV in the past decades. TDF nephrotoxicity has been reported and could lead to renal failure and Fanconi Syndrome (FS). Case: A 58-year-old female HBsAg carrier with TDF treatment since 2013 presented with osteomalacia. She had glucosuria, albuminuria, vitamin D insufficiency, hypophosphatemia, and occasional hypokalemia episodes. Laboratory results showed amino aciduria, which indicates renal tubulopathy. The diagnosis of Fanconi syndrome was confirmed. Withdrawal of TDF was followed by improvement. Conclusion: The acquired FS associated with TDF is reversible. The use of TDF-containing antiviral regimens should be followed by screening recommendations to detect early Fanconi syndrome.
Co-Authors Sidharta Salim