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All Journal Narra J
Mudatsir Mudatsir
Department of Microbiology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Antibacterial and anti-inflammatory activities of Nothopanax scutellarium, Moringa oleifera and Piper betle extracts on staphylococcal mastitis animal model Cut Sriyanti; Tongku N. Siregar; Mudatsir Mudatsir; Azhari Gani; Denny I. Hasan; Amalia Sutriana
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.176

Abstract

Inappropriate and prolonged administration of antibiotics in mastitis could cause antibiotic resistance and herbal treatment might could be one alternative treatment. Nothopanax scutellarium, Moringa oleifera, and Piper betle are medicinal plants that contain various active compounds, including antibacterial and anti-inflammatory agents, but their potentials in treating mastitis are not well understood. The aim of this study was to assess the effectiveness of those plants against mastitis in rabbit model induced by Staphylococcus aureus. A total of 25 lactating rabbits (Oryctolagus cuniculus) weighing 3.0±0.4 kg were grouped into five groups: healthy control; mastitis control, and three treatment groups (Nothopanax scutellarium, Moringa oleifera, and Piper betle). Except the healthy control group, all animals were inoculated with 0.15 mL of Staphylococcus aureus containing 1.5x107colony forming unit (CFU)/mL on eight days after giving birth. The extract was administered orally after four hours Staphylococcus aureus inoculation at a dose of 50 mg/kg body weight, twice a day for five consecutive days. The number of bacteria in the milk and the level of serum interleukin 6 (IL-6) were measured and histopathological examination of mammary gland tissues were analyzed. The log number of total plate count of Staphylococcus aureus indicated that all extract groups had significant lower of bacterial logs compared to mastitis control (all comparisons had p<0.05) with the lowest was found in Piper betle group, followed by Nothopanax scutellarium and Moringa oleifera. The enzyme-linked immunosorbent assay (ELISA) results showed that all ethanolic extract groups had significantly lower levels of IL-6 compared to the mastitis control (all comparisons had p<0.05). The histopathologyassessment suggested that extract groups had lower infiltration of inflammatory cells such as lymphocytes and macrophages in alveoli compared to the mastitis control group. In conclusion, all three extracts contained antibacterial and anti-inflammatory activities and Piper betle had the most effective in reducing bacterial growth and IL-6 level compared to others.
Development and preclinical evaluation of an Aceh kelulut honey-based hydrocolloid dressing for wound healing Muhammad IA. Putra; Khairan Khairan; Izza Chairani; Binawati Ginting; Kartini Hasballah; Reno K. Kamarlis; Mudatsir Mudatsir; Syamsul Rizal; Mirnasari Amirsyah; Muhammad Diah
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3121

Abstract

Honey has long been used in wound care because of its antibacterial and anti-inflammatory properties, while hydrocolloid dressings provide a moist and protective environment that supports tissue repair. This study aimed to evaluate the macroscopic and microscopic effects of an Aceh kelulut honey–based hydrocolloid dressing on wound healing in mice. Twenty-seven healthy male mice (Mus musculus) were assigned to three groups: control treated with 0.9% NaCl, pure Aceh kelulut honey (KH), and Aceh kelulut honey–based hydrocolloid (KHHC). Two full-thickness excisional wounds, each 4 mm in diameter, were created on the dorsal skin of each mouse. Wound diameter was measured daily for 14 days. Histopathological evaluation was performed on days 3, 7, and 14 to assess neutrophil and macrophage counts, epithelialization ratio, myofibroblast ratio, and collagen fiber density. The KHHC group showed faster macroscopic wound closure than the KH and control groups. Significant differences were observed among groups in neutrophil count, macrophage count, epithelialization ratio, myofibroblast ratio, and collagen fiber density. KHHC reduced inflammatory cell infiltration, increased myofibroblast ratio, and enhanced collagen fiber density, suggesting accelerated wound contraction and tissue remodeling. However, epithelialization was lower in the KHHC group during the early healing phase. These findings indicate that Aceh kelulut honey–based hydrocolloid dressing may improve several key aspects of wound healing, particularly inflammation control, wound contraction, and collagen deposition. Further studies are required to optimize the formulation and clarify its effect on reepithelialization.
Co-Authors Amalia Sutriana Azhari Gani Binawati Ginting Cut Sriyanti Denny I. Hasan Izza Chairani Kartini Hasballah Khairan Khairan Mirnasari Amirsyah Muhammad Diah Muhammad IA. Putra Reno K. Kamarlis Syamsul Rizal Tongku N. Siregar