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All Journal Jurnal Kedokteran Diponegoro JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA
Hanna Goenawan
Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia
Education Medicine & Pharmacology Public Health

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Effects of Different Intensity Exercises On Bone Structure of Young Male Wistar Rats Filiani Natalia Salim; Hanna Goenawan; Faysal Kastella; Ronny Lesmana; Leonardo Lubis
JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Vol 8, No 2 (2023): Health Benefits of Exercise and Physical Activity
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpjo.v8i2.59086

Abstract

Many adolescents have insufficient physical activity. Regular physical activity from young age can improve health and fitness. Getting regular exercise and eating healthy diet should be encouraged among kids and teenagers to prevent various diseases in adulthood and old age, such as osteoporosis and fractures. When exercising, a prescription is needed that is tailored to each individual abilities. The intensity of exercise will be different for each individual in accordance with their age, physiological function, genetics, economic status, and previous comorbid diseases. There is no standardised exercise prescription proven to increase bone mineral density in adolescents. Based on the above description, a study was conducted on the provision of different intensity exercise and its effect on bone morphology and density. In this study, male Wistar rats, aged 15–16 weeks (body weight ± 250-350 grams; n = 20), were split into 4 groups, namely control group, low intensity exercise group, moderate intensity exercise group, and high intensity exercise group. All groups were receiving intervention for 8 weeks. Then, the rats were sacrificed and the femoral bones were isolated. Femur weight and femur length was checked. Bone density was examined using X-Ray and calculated by statistical tests. Research was conducted in the Central Laboratory, Universitas Padjadjaran. There were significant differences of femur weight between high intensity exercise group and control and low intensity exercise groups (p 0.05). Moderate and high intensity exercises significantly increased femur length as opposed to control and low intensity exercise groups (p 0.05). Bone density was higher in moderate and high intensity exercise groups (p 0.05). Moderate to high intensity exercise can increase bone health, seen from significances of bone morphology analysis and a higher density compared to low intensity exercise.
EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS Hanna Goenawan; Raisa Zahra; Putri Teesa Radhiyanti; Julia Ramadhanti; Vita Murniati Tarawan; Fifi Veronica
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 6 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i6.50802

Abstract

Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause of inflammation and pain. However, chronic TRPV1 activation triggered by exercise can cause TRPV1 desensitization. Objective: Aim of this study was to examine the effect of different intensity exercise on TRPV1 mRNA expression in gastrocnemius muscle. Methods: This study was experimental study using animals models. Rats aged 12-24 weeks were given exercise interventions, a treadmill protocol, 5 times a week (30 min/day) with low (10 m/s), moderate (20 m/s), and high (30 m/s) intensity for 8 weeks. After exercise period, gastrocnemius muscle were isolated and subjected for TRPV1 mRNA expression analysis using semi quantitative real time PCR. Results: There was no changes of TRPV1 mRNA gene expression in gastrocnemius after treatment of different intensity exercise (p =0.694). Conclusion: As the conclusion, 8 weeks different intensity of exercise did not alter TRPV1 expression in gastrocnemius. 
Co-Authors Faysal Kastella Fifi Veronica Filiani Natalia Salim Julia Ramadhanti Leonardo Lubis Putri Teesa Radhiyanti Raisa Zahra Ronny Lesmana Vita Murniati Tarawan