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All Journal Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE
Irfannuddin Irfannuddin
Department of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Relationship Between The Location Of Benign Vocal Cord Lesion And The Degree Of Voice Handicap Index-30 Lisa Apri Yanti; Irfannuddin Irfannuddin; Nilam Kusuma Anggraeni
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v9i1.134

Abstract

Introduction. Voice disorder or dysphonia is a condition that includes all changes in a person’s voice including tone, intensity, phonation, and others caused by laryngeal disorders. Each sound production disorder can be evaluated through the VHI-30 questionnaire. Therefore, data are needed regarding the relationship of the extent of the lesion location site to the degree of VHI-30 produced in dysphonic patients with benign vocal cord lesions. Methods. Observational research using cross sectional design. Data collection using medical record data on 30 dysphonic patients with benign vocal cord lesions who underwent surgery in the ENT department in RSMH in January 2019 to June 2022. Results. Out of the 30 patients with benign vocal cord lesions, age of 31-45 and 46-60 age groups were most found 11(36,7%) Female gender was found 16(53,3%) and the non-professional voice user category was found the highest 28 (93,3%). The 1–6-month onset group was the highest 12(40,0%). The most common location of benign vocal cord lesions was in 1/3 anterior 8(26,7%), and the most common type of benign lesion was vocal cord nodules 13(43,3%). Severe degree VHI-30 were most found 18(60,0%). The area of bilateral locations along the vocal cords had a significant relationship, with p-value of 0,040 (p<0,05), to the degree of VHI-30 when compared to the unilateral location of the anterior 2/3 of the vocal cords. Conclusion. The benign lesions’ position of bilateral along the vocal cord has a significant relationship to the severe degree of VHI-30
Bioinformatics Analysis of Disc Large Homolog-4 (DLG-4) As Parameters in Neuroplasticity Eka Febri Zulissetiana; Irfannuddin Irfannuddin
Sriwijaya Journal of Medicine Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i3.206

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Disc Large Homolog-4 (DLG-4), also known as Post Synaptic Density 95 (PSD95) is believed to have an important role in the function and organization of the synapse. DLG-4 is the main protein structure at the synapse that is able to bind to various molecules on the surface of the postsynaptic membrane. This review aims to determine the biomolecular characteristics of DLG-4 and the role of DLG-4 as an important parameter in neuroplasticity. Biomolecular characteristic analysis was obtained through various bioinformatics websites namely NCBI, PROTPARAM, TMHMM, PEPTIDE CUTTER, NETNGLYC, TARGETP and KEGG PATHWAY. The DLG-4 gene is located on chromosome 17p13.1 and has 25 exon. The DLG-4 protein consists of 764 amino acids with a molecular weight of 80.47 kDa. DLG-4 has a structure of 3 N-terminal PDZ domains, a Src Homology 3 (SH3) domain and a guanilate kinase-like C-terminal domain. This protein has a stability score of 48.61. The aliphatic index is 85.42. DLG-4 is found inside, outside, and on transmembranes, as determined by THMM. There are 37 enzymes that are predicted to be able to split the DLG-4 protein. The DLG-4 protein shows 3 potential sites of glycosylation of amino acids. The target location of the DLG-4 protein is mostly in other locations (other = 0.6556), secretory pathway (0.3328), and only slightly in mitochondria (0.0116). The DLG-4 protein is strongly associated with the glutamatergic system in postsynaptic neurons. The glutamatergic system is concerned with the molecular mechanism of memory development and cognitive function, long-term potentiation (LTP). These findings support the fact that DLG-4 protein plays a role in neuroplasticity mechanisms in the brain.
Comparison of Germ Patterns between Cholesteatom Tissue and Tympanic Cavum Mucosa Tissue in COSM with Cholesteatom at Dr. Mohammad Hoesin Hospital, Palembang Resti Ramdani; Abla Ghanie; Fiona Widyasari; Ahmad Hifni; Irfannuddin Irfannuddin
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.218

Abstract

Chronic Suppurative Otitis Media (CSOM) is middle ear inflammation due to infection characterized by otorrhea through perforation of the tympanic membrane that occurs for more than three months. Identifying bacterial patterns in CSOM is essential for managing CSOM patients with cholesteatoma. Proper administration of antibiotics is crucial to overcome infection and prevent widespread resistance. To compare the germ patterns between cholesteatoma tissue and tympanic cavum mucosal tissue in CSOM patients with cholesteatoma. This observational study has a cross-sectional design, and data collection was carried out using primary data taken from 27 CSOM patients with cholesteatoma who underwent mastoidectomy surgery with a total of 54 research samples taken from the examination of cholesteatoma tissue swabs and tympanic cavum mucosal tissue from August to October 2023. From the reliability coefficient between the two tissues using the Cohen's Kappa technique, there is a significant concordance in the germ pattern between the tympanic cavum mucosa tissue and the tympanic cavum mucosa of 0.580 (Moderate) p<0.005, with Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumoniae with a significance value of 0.656 (Good) p<0.001. There is a significant concordance in the germ pattern between cholesteatoma tissue and tympanic cavum mucosa tissue in CSOM cases with cholesteatoma. The most common bacteria in both tissues are Gram-negative, namely Pseudomonas aeruginosa, proteus mirabilis, and Klebsiella pneumoniae.
Co-Authors Abla Ghanie Ahmad Hifni Eka Febri Zulissetiana Fiona Widyasari Lisa Apri Yanti Nilam Kusuma Anggraeni Resti Ramdani