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Marwoto, .
Faculty of Medicine, Sebelas Maret University
Biochemistry, Genetics & Molecular Biology

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Interferon Gamma of Multidrug-resistant Tuberculosis (MDR-TB) Patients in Dr. Moewardi Hospital in Surakarta Setyawan, Hanif Hary; Hudiyono, .; Marwoto, .; Prasetyo, Afiono Agung
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Interferon-γ (IFN-γ) produced by CD4+(Th1) T cells plays a critical role in immunityto tuberculosis infection. MDR-TB patients have decreased T cell IFN-γproduction capacity. Data of IFN-γ plasma level of MDR-TB patients in Indonesia, include its association with age and gender, are not yet known. This study was aimed to identify the profile of IFN-γ on plasma of MDR-TB patients in Dr. Moewardi Hospital in Surakarta and its association with age and gender. Methods: Blood samples and medical record’s data from 43 MDR-TB patients in Dr. Moewardi Hospital in Surakarta were collected. Enzyme-linked immunosorbent assay (ELISA) serological test was done to measure IFN-γtiter. Results: Twenty samples (46.5%, 20/43) had elevated IFN-γ level in their plasma. Elevated IFN-γ level was more likely to be found in women (OR 3.63; 95% CI 1.02-12.94) and respondentsaged 21-30 years (OR 4.5; 95% CI 0.79-25.57). No association between elevation of IFN-γ level with age (p = 0.450) and gender (p = 0.067). Conclusions: Elevated IFN-γ level was found in 46.5% of MDR-TB patients in Dr. Moewardi Hospital in Surakarta.Elevated IFN-γ level was more likely to be found in women and respondents aged 21-30 years. Keywords: IFN-g, MDR-TB, Surakarta  
Co-Authors Hudiyono, . Prasetyo, Afiono Agung Setyawan, Hanif Hary