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All Journal Jurnal Ilmiah Wahana Pendidikan Journal of Pharmaceutical and Sciences.
Dhavid Twua Mangunsong
Universitas Buana Perjuangan Karawang
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS TERAPI OBAT GOLONGAN STATIN TERHADAP PASIEN DISLIPIDEMIA Dhavid Twua Mangunsong; Maya Arfania; Renita Hamjah; Wipena Fariza
Jurnal Ilmiah Wahana Pendidikan Vol 9 No 16 (2023): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.8251366

Abstract

Tujuan review artikel ini yaitu untuk mengetahui Efektivitas Terapi Obat Golongan Statin Terhadap Pasien Dislipidemia. Dalam artikel ini menyajikan ringkasan yang komprehensif mengenai Efektivitas Terapi Obat Golongan Statin Terhadap Pasien Dislipidemia. Adapun kriteria yang digunakan yaitu jurnal ilmiah yang dimaksudkan berupa naskah publikasi nasional dan internasional dengan tema berfokus pada Efektivitas Terapi Obat Golongan Statin Terhadap Pasien Dislipidemia. Jumlah studi yang digunakan dalam review jurnal ini sebanyak 10 jurnal yang dimuat ke dalam hasil dan pembahasan. Hasil penelitian menunjukkan bahwa Statin adalah kelompok obat yang efektif dalam mengatasi dislipidemia, kondisi yang ditandai oleh tingginya kadar lipid (kolesterol dan trigliserida) dalam darah. Penelitian dan studi klinis menunjukkan bahwa penggunaan statin secara konsisten dan dalam dosis yang tepat dapat mengurangi kadar kolesterol LDL (kolesterol jahat) dan trigliserida, serta meningkatkan kadar kolesterol HDL (kolesterol baik) pada pasien dislipidemia.
Uji Hepatoprotektif Fraksi N-Heksana Kulit Batang Jamblang (Syzygium Cumini (L.) Skeels) Ditinjau Dari Kadar Ast, Alt, Dan Albumin Surya Amal; Himyatul Hidayah; Neni Sri Gunarti; Dhavid Twua Mangunsong
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1291

Abstract

The liver plays an important role in the metabolism and detoxification of harmful substances in the body. One of the drugs that can cause liver damage if used excessively is paracetamol. Liver damage due to paracetamol is characterized by an increase in the levels of AST (aspartate aminotransferase) and ALT (alanine aminotransferase) enzymes as well as a decrease in albumin levels in the blood. The bark of the jamblang tree (Syzygium cumini) contains flavonoid compounds, tannins, and triterpenoids that have antioxidant properties and may possess hepatoprotective effects. This study aims to evaluate the effect of the n-hexane fraction of jamblang bark on liver function parameters in male Wistar strain white rats induced with paracetamol, and to determine the most effective dose. This study involved 20 rats divided into five treatment groups: negative control (paracetamol 1000 mg/KgBB), positive control (silymarin 50 mg/KgBB), and three test groups that were given n-hexane fraction at graded doses (50, 100, and 200 mg/KgBB). The treatment was given for 21 days, while paracetamol was administered from day 15 to day 21. The results showed that the levels of AST and ALT were significantly affected by the n-hexane fraction of jamblang bark at a dose of 50 mg/KgBB with p < 0.0001 for AST and p = 0.0002 for ALT. Meanwhile, albumin levels were significantly affected at a dose of 200 mg/KgBB with p = 0.0411. From the results, it can be concluded that the n-hexane fraction of jamblang bark has the potential as a hepatoprotective agent, especially at a dose of 50 mg/KgBW.
Co-Authors Gunarti, Neni Sri Himyatul Hidayah Maya Arfania Renita Hamjah Surya Amal Wipena Fariza