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All Journal HAYATI Journal of Biosciences Journal of Medical Physics and Biophysics
Nuzulia, Nur Aisyah
Department Of Physics, Faculty Of Mathematics And Natural Sciences, Bogor Agricultural University
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Medicine & Pharmacology Physics

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The Effect of Casein Addition in Carbonate Apatite Mineral Crystallization Nur Aisyah Nuzulia; Savitri Damayanti; Serin Imsa Arizuni; Yessie Widya Sari
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.824 KB)

Abstract

Milk protein has been considered as one of the influenced factors in bone mineral crystallization. Bone mineral is mainly formed by carbonate apatite in which the crystallization process depends on the two main processes, nucleation and crystal growth. This study showed the formation of carbonate apatite by using precipitation method and observed the influence of casein, milk protein, in carbonate apatite nucleation through synthesis and crystal growth through immersion in SBF.  The result showed that carbonate apatite type B was formed by using precipitation method with chicken eggshells as calcium precursor. The addition of casein concentration could promote the apatite nucleation and crystal growth with low casein concentration ( ≤ 7.5 g.l-1) while high casein concentration addition plays role as an inhibitor.
Injectable Bone Substitute Synthesized from Mangrove Snail Shell Yessie Widya Sari; Reza Pahlevi Rudianto; Nur Aisyah Nuzulia; Sulistioso Giat Sukaryo
Journal of Medical Physics and Biophysics Vol 4, No 1 (2017)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

The need for biomaterials tends to increase especially in the field of medicine caused by cases of increasing bone damage. The biomaterial that is being developed for bone implants is hydroxyapatite (HAp). The high value of imports of bone-replacement biomaterials in Indonesia is conidered as a thoughtful problem because of the high price, therefore the development of biomaterials used as a substitute for bone derived from natural materials. In this study, HAp in the form of an injectable bone substitute (IBS) was syntehsized. IBS is a bone-substitute material in the form of a suspension. IBS can be applied by injection to reach deeper areas of bone defects and be able to adjust the shape of bone or tooth defects properly. HAp was synthesized in this study with assistance of microwave irradiation. Mangrove snail shell was used as calcium sources. Furthermore, this study indicated that HAp synthesized from mangrove snail shell had a high potency to be developed as IBS.
Effect of Phosphate-based Glass Porous Microspheres (P30) Loaded with Extracellular Vesicle on Osteoblast Behaviour: In Vitro Study Cahayadi, Sigit Daru; Nuzulia, Nur Aisyah; Boediono, Arief; Ahmed, Ifty; Nurhayati, Retno Wahyu; Sari, Yessie Widya; Juliandi, Berry
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.840-849

Abstract

Bioactive materials, particularly phosphate-based glasses (PBG), hold great promise in bone repair due to their controllable degradation rates and bioactivity. This study evaluated PBG porous microspheres (P30) loaded with extracellular vesicles (EVs) for bone tissue engineering, focusing on osteogenesis, EV uptake, and cell invasion. P30 concentrations (5P30, 10P30, 50P30, 100P30, 500P30) were tested for their effects on calcification, EV uptake, and cell migration. Results showed that 100P30 exhibited optimal conditions for osteogenesis and EV delivery, with the highest calcification areas at both Day 7 and Day 14 and the most efficient EV internalization. Meanwhile, 500P30 demonstrated the highest cell migration, supporting pre-osteoblastic migration at this concentration. These findings indicate that 100P30 is ideal for mineralization and EV uptake, while 500P30 enhances cell invasion. This study highlights P30's versatility as a biomaterial for bone regeneration, with specific concentrations tailored to different regenerative goals. These results underscore the potential of P30 microspheres loaded with EVs as an effective strategy for promoting bone repair and regeneration.
Co-Authors Ahmed, Ifty Arief Boediono Berry Juliandi Cahayadi, Sigit Daru Nurhayati, Retno Wahyu Reza Pahlevi Rudianto Savitri Damayanti Serin Imsa Arizuni Sulistioso Giat Sukaryo Yessie Widya Sari