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All Journal Magna Neurologica Lumina: Indonesian Journal of Neurology
Anyeliria Sutanto
Universitas Pelita Harapan
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Atypical Chronic Inflammatory Demyelinating Polyneuropathy With Relapsing Sensory-Predominant Sensorimotor Neuropathy Yee Wen Yong; Bryan Setyoputra; Annisa Kusuma Dewi; Anyeliria Sutanto
Lumina : Indonesian Journal of Neurology Vol. 1 No. 3 (2025): December: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v1i3.10338

Abstract

Introduction: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, acquired autoimmune neuropathy with progressive symptoms. Intravenous immunoglobulin (IVIg) and corticosteroids are effective first-line therapies; however, many patients experience residual symptoms or relapse within the first year.Case Presentation: A 39-year-old male with an initial diagnosis of carpal tunnel syndrome presented with a 13-month history of progressive sensory disturbances, evolving from lower limb paresthesia with gait instability. EMG confirmed demyelinating and axonal sensorimotor polyneuropathy consistent with CIDP. He was hospitalized and responded well to intravenous methylprednisolone and IVIg, but relapsed nine months later after a respiratory infection, presenting with distal sensory symptoms and preserved strength. Cerebrospinal fluid analysis showed albuminocytologic dissociation, while autoimmune nodopathy markers were negative. Retreatment with IVIg and methylprednisolone led to clinical improvement, with only mild exertion-related symptoms at two-month follow-up.Discussion: This case highlights a rare sensory-predominant variant of CIDP with relapse triggered by infection. Relapses often require renewed immunotherapy, with corticosteroids and IVIg as first-line treatments; long-term management may include maintenance IVIg and gradual steroid tapering.Conclusions: Early recognition, appropriate immunotherapy, and long-term monitoring are essential to sustain remission and prevent disability in sensorypredominant CIDP.Keywords: Chronic inflammatory demyelinating polyneuropathy; electrodiagnostic studies; immunotherapy; relapse; sensory-predominant
Clinical Profile And Risk Factors Of Stroke: A Comparative Analytical Study Between Young And Old Onset Reza Stevano; Jacqueline Tasha Margono; Anyeliria Sutanto
Magna Neurologica Vol. 1 No. 1 (2023): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i1.470

Abstract

Background: With ever-increasing incidence, young-onset stroke is responsible for significant psychosocial and economic burden, primarily due to post-stroke disability in the productive population. Objective: The aim of our study is to assess the profile and risk factors in young-onset stroke compared to those in older patients. Methods: This was a retrospective cross-sectional study. We included all patients with acute stroke, or transient ischemic attack (TIA) treated at Siloam Lippo Village Hospital between October 2021 and February 2022. An independent t-test was conducted for continuous variables with normal distribution and a Mann-Whitney U test for ordinal or continuous variables with non-normal distribution. Pearson's chi-square test was performed for categorical variables. Results: 153 patients with acute stroke and TIA were included. On univariate analysis comparing young and old-onset strokes, significant differences were found in diagnosis (p=0.039), Bamford classification (p=0.022), NIHSS (p=0.014), history of smoking (p=0.012), previous stroke (p=0.045), history of coronary artery disease (p=0.026), and routine antiplatelet use (p=0.018). Conclusion: We found a predominance of hemorrhagic stroke and TIA in the young-onset group, with more common involvement of the anterior circulation. Older onset was associated with a higher NIHSS score. Modifiable risk factors are more common in young-onset stroke, while non-modifiable risk factors are more common in the older population. However, hypertension remains an equally important risk factor in both groups. Our study provides an overview of the profile and risk factors for young-onset stroke. The information obtained can be useful as educational material for the community to prevent young-onset stroke.
Co-Authors Annisa Kusuma Dewi Bryan Setyoputra Jacqueline Tasha Margono Reza Stevano Yee Wen Yong