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All Journal Tropical Genetics
Cut Muthiadin
State Islamic University Alauddin Makassar

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The potential of microsatellite markers on the identification of various ethnic alleles in Indonesia Husnul Sri Mulyani Harja; Cut Muthiadin
Tropical Genetics Vol. 3 No. 1 (2023):
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v3i1.37

Abstract

Indonesia is an archipelagic country with a high level of population diversity such as religion, ethnicity, culture and also genetic diversity. Environmental factors also have an impact on the genetic variation and diversity of the population, including high mobility and migration triggering the tendency for inter-ethnic marriages to occur. This environmental factor is one of the reasons for research based on DNA analysis on ethnicity in Indonesia for the purpose of forensic identification. One of the DNA analyzes for forensic identification is the microsatellite DNA analysis method with a high sensitivity level.
Literature review on the genetic variability of Escherichia coli in clinical isolates: relationship with antibiotic resistance and virulence factors Magfirah Rahimah Rum; Cut Muthiadin
Tropical Genetics Vol. 5 No. 1 (2025): Genetics
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v5i1.82

Abstract

Escherichia coli is a natural flora found in the intestine, but Escherichia coli is also a major repository of resistance genes that may be responsible for treatment failure in humans and animals. This study aims to understand and evaluate the genetic variability of Escherichia coli in clinical isolates and to determine the correlation between genetic variability and antibiotic resistance. This study uses a literature review method. This study presents the results of a search for studies related to the topic, namely the genetic variability of Escherichia coli in clinical isolates and the relationship with antibiotic resistance and virulence factors. The criteria for articles used as data are articles published in the last 10 years, namely from 2015 to 2025. Based on the research that has been done, it can be concluded that genetic variability in Escherichia coli in clinical isolates plays an important role in adaptation, pathogenicity, and antibiotic resistance. Mechanisms such as horizontal gene transfer (HGT), mutations, and genome rearrangements allow E. coli to acquire virulence genes and antibiotic resistance genes, such as genes encoding extended-spectrum β-lactamases (ESBLs) including TEM, SHV, and CTX-M. These genes are often located on mobile plasmids, which support the spread of resistance between bacterial strains and species, complicating infection control and clinical treatment.