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All Journal International Journal of Social Service and Research
Ameru U
Faculty of Medicines, Universitas Indonesia
Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Social Sciences

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Negative Effects Of Protamine On Myocardium In Paediatrics Patients Undergoing Cardiac Surgery Using A Cardiopulmonary Bypass Machine Suprayitno Suprayitno; Dhama Shinta S; William M; Muhammad Eros Z S; Ameru U; Atya Sabrina M
International Journal of Social Service and Research Vol. 3 No. 11 (2023): International Journal of Social Service and Research (IJSSR)
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v3i11.601

Abstract

The administration of protamine, a heparin reversal agent, is an integral part of cardiovascular bypass protocols, particularly in the post-bypass phase. In paediatric cases, protamine is administered in a titration dose. The use of protamine is associated with various adverse events, including myocardial impairment. Proper dosage adjustment is crucial during protamine administration, as excessive doses may result in the depression of myocardial function. Experimental studies examining protamine usage have revealed myocyte impairments, such as reduced myocyte contractility, dysfunction in signaling pathways, and alterations in cardiac receptors. Despite these findings, research on the impact of pediatric protamine on the myocardium remains limited and necessitates further investigation.
Co-Authors Atya Sabrina M Dhama Shinta S Muhammad Eros Z S Suprayitno Suprayitno William M