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All Journal Pharmacon Journal of Islamic Pharmacy Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy Pharmacon: Jurnal Farmasi Indonesia
Teguh Imanto
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Islamic Pharmacy

 1 
PEMBENTUKAN DAN KARAKTERISASI FISIKA KIMIA KO-KRISTAL PIROXICAM-ASAM TARTRAT-SAKARIN DENGAN METODE SOLVENT DROP GRINDING Imanto, Teguh; Pertiwi, Hany Kartika; Wikantyasning, Erindyah Retno
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.24449

Abstract

Piroxicam merupakan obat turunan asam enolat (oksikam) sebagai antiinflamasi nonsteroid (NSAID). Piroxicam digunakan untuk mengurangi atau menghilangkan resiko rheumatoid arthritis dan osteoarthritis. Piroxicam dikategorikan sebagai BCS (Biopharmaceutical Classification System) kelas II yaitu memiliki kelarutan rendah dan permeabilitas tinggi. Tujuan dari penelitian ini ialah untuk meningkatkan kelarutan obat piroxicam yang telah termodifikasi ko-kristal pada uji kelarutan dan mengkarakterisasi sifat fisika kimia ko-kristal piroxicam meliputi uji Fourier Transform Infra Red (FTIR), uji Differential Scanning Calorimetry (DSC), uji X-Ray Diffraction (XRD), uji sifat alir, dan uji kerapatan mampat. Pembentukan ko-kristal menggunakan metode Solvent Drop Grinding dengan cara menggerus secara bersama-sama piroxicam, asam tartrat, sakarin selama 15 menit, kemudian ditambahkan sedikit pelarut metanol dan disimpan pada eksikator. Ko-kristal yang terbentuk diuji karakterisasi sifat fisika kimianya. Hasil analisis menunjukkan ko-kristal piroxicam asam tartrat-sakarin perbandingan molar 1:1:1 dalam pelarut HCl 0,1 N memiliki kelarutan yang lebih tinggi dibandingkan piroxicam murni dan ko-kristal piroxicam asam tartrat-sakarin perbandingan molar 2:1:1. Hasil analisis ko-kristal formula 1 (1:1:1) pada uji FTIR menunjukkan panjang gelombang serapan gugus C=O karboksilat yaitu 1736,73 cm-1, hasil uji XRD mengalami penurunan intensitas puncak difraksi pada sudut 8, 14, 17 dan 27o yaitu 1431,23, 1081,58, 1726,28 dan 1228,92 cts. Hasil uji DSC mengalami penurunan titik leleh 163,90oC dan penurunan energi entalpi 53,97J/g. Ko-kristal formula 1 memiliki rata-rata indeks kompresibilitas yaitu 10,8%, hasil uji kelarutan piroxicam dalam pelarut HCl 0,1 N yaitu 59,10 mg/mL.
Advances in Electrospun Polymer-Based Nanofibers for Wound Healing: A Narrative Review Imanto, Teguh; Zahra, Veirda
Journal of Islamic Pharmacy Vol 9, No 2 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i2.30062

Abstract

Polymer-based nanofibers produced using electrospinning techniques have become a significant innovation in drug delivery systems, particularly in wound healing. The nanofiber structure, which resembles the extracellular matrix (ECM), provides an advantage in supporting tissue regeneration and drug release control, making it an effective solution for the treatment of acute and chronic wounds. The aim of this review is to analyze recent advancements in the use of polymer-based nanofibers for drug delivery in wound healing therapy. The method used is a systematic approach with modified PRISMA guidelines. Relevant literature was extracted from the ScienceDirect database using the keywords "polymers", "nanofiber", "electrospinning" and "wound healing," with the publication period limited to 2016–2025. From the search results that yielded 5,750 articles, a strict selection process narrowed them down to 21 relevant articles for analysis. The analysis results show that polymer-based nanofibers such as PVA, PCL, and PVP demonstrate outstanding abilities in delivering antibacterial drugs, enhancing wound healing efficiency, and combating infections, especially in chronic wounds. Nanofiber technology also provides innovative solutions in mitigating bacterial resistance. In conclusion, polymer-based nanofibers open significant opportunities in the pharmaceutical field and wound healing therapy with more precise and effective drug release control.
Co-Authors Anggraeni, Wahyu Puspita Annisa, Nabilah Shafa Erindyah Retno Wikantyasning Khadijah Zai Nonni Soraya Sambudi Pertiwi, Hany Kartika Roseh Prasetiawan Teuku Nanda Saifullah Sulaiman Wahyu Puspita Anggraeni Zahra, Veirda