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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan JURNAL FARMASIMED (JFM) Jurnal Katalisator Riset Informasi Kesehatan Pharmacon: Jurnal Farmasi Indonesia
Teuku Nanda Saifullah Sulaiman
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Formulation of fenofibrate nanocrystals with wet milling method M. Henityo Agung As'adi; Ilham Kuncahyo; Teuku Nanda Saifullah Sulaiman
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.761

Abstract

Background: Fenofibrate is an antihyperlipidemic belonging to BCS class II, practically insoluble in water and has high lipophilicity, so it is proven that the inhibitor of the rate of absorption of fenofibrate from the digestive tract is slow to dissolve. This study aims to increase the solubility of fenofibrate by forming nanocrystals. Method: Formation of nanocrystals using the wet milling method Result: The fenofibrate nanocrystals produced a particle size of 775.966 nm, a zeta potential of -21.302 mV, and a solubility of 5.977 μg/mL. Conclusion : The optimum formula with tween 80 components, grinding speed and grinding time in the manufacture of fenofibrate nanocrystals using the Factorial Design method obtained 0.2% tween 80, grinding speed of 500 rpm and grinding time of 1 hour. The critical parameter test results for the optimum formula obtained a particle size of 775.966 nm, a zeta potential of -21.302 mV and a solubility of 5.977 µg/mL. The DSC test showed that there was a difference in the melting point peaks and a decrease in crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The FTIR test showed no difference in functional groups between pure fenofibrate and fenofibrate nanocrystals. The XRD test showed that there was a difference in peak crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The SEM analysis shows that there are differences in shape and magnification used between pure fenofibrate and fenofibrate nanocrystals.
Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review Imanto, Teguh; Nonni Soraya Sambudi; Khadijah Zai; Teuku Nanda Saifullah Sulaiman
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6986

Abstract

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These systems offer localized, sustained drug release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) and Polycaprolactone (PCL), which ensure controlled drug release while supporting bone regeneration. A systematic search using PRISMA guidelines across ScienceDirect and ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion of bioactive agents such as hydroxyapatite in nanofibers was found to enhance antibacterial properties and accelerate tissue regeneration. The review demonstrates that antibiotic-loaded nanofibers offer a promising, targeted therapeutic alternative to conventional treatments, particularly for osteomyelitis and similar challenging bone infections. Future research directions will focus on optimizing nanofiber compositions and functionalities to better meet clinical needs, ensuring more efficient and personalized management of severe bone infections.
FORMULATION ANTIAGING CREAM MELASTOMA MALABATCHRICUM EXTRACT WITH POLYOXYETHYLENE MONOSTEARATE AND STEARIC ACID Mukti, Yusuf Anggoro; Gunawan Pamudji Widodo; Teuku Nanda Saifullah Sulaiman
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3045

Abstract

Karamunting fruit (Melastoma malabathricum L.) contains flavonoids, triterpenoids and tannins. The purpose of this study was to make anti-aging cream preparations using caramunting fruit extract with a combination of PEG 40 stearic acid and stearic acid to obtain optimum physical quality. Extract with 96% ethanol filter in the form of extracts used for cream preparations using a base of PEG 40 stearic and stearic acid, so that 8 formulas were obtained, then optimized based on the physical quality parameters of viscosity, spreadability, adhesion and pH, then optimization of the formula to determine the formula optimum using the Simplex Lattice Design method. The conclusion obtained based on this research is the optimum combination of PEG 40 stearic and stearic acid in the cream of caramunting fruit extract using the Simplex Lattice Design method, namely PEG 40 Stearate 4.76% and stearic acid 15.74%. The physical quality stability did not change during one month of storage and the cream did not cause irritation. Formula I had a better and almost equal effect on the collagen test while formula V had a better effect on the elasticity test and the moisture test.
Evaluation of Drug Storage Systems Based on Good Distribution Practice in Pharmaceutical Wholesalers in Indonesia: A Systematic Review Martsom Putra Sulung S Langga; Teuku Nanda Saifullah Sulaiman; Satibi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/fnws3q19

Abstract

The pharmaceutical distribution system plays a crucial role in ensuring that medicines maintain their quality, safety, and efficacy throughout the supply chain. In Indonesia, Pharmaceutical Wholesalers (PBF) are required to implement Good Distribution Practice (CDOB), including proper storage systems; however, variations in compliance have been reported in several local studies. Purpose: This study aimed to identify the implementation of drug storage systems in PBF in Indonesia based on CDOB and to analyze the most frequent areas of non-compliance. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Literature searches were performed in Google Scholar and Semantic Scholar for studies published between 2014 and 2024. Primary observational descriptive studies focusing on drug storage practices in Indonesian PBF were included, and seven eligible articles were analyzed. Result: The findings indicate that non-compliance most frequently occurs in the operational aspect, particularly in the inconsistent implementation of FEFO, medicines classification, and adherence to standard operating procedures. Issues related to building and equipment, such as unstable temperature control and inadequate ventilation, are also commonly reported. Weaknesses in documentation, stock verification, and managerial oversight further affect storage effectiveness. Conclusion: These recurring patterns suggest that challenges lie more in implementation consistency and internal control rather than regulatory absence. Overall, drug storage practices in Indonesian PBF generally refer to CDOB standards; however, compliance remains uneven. Strengthening operational discipline, documentation accuracy, and managerial supervision is essential to improve distribution quality and ensure patient safety.
Comparison of Thin Layer Hydration and Dispersion Method of Transfersome Formulation Containing Hyaluronic Acid and Glutathione as Antioxidant Dian Ermawati; Adhyatmika; Yuniarti, Nunung; Teuku Nanda Saifullah Sulaiman
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44450

Abstract

Glutathione is a tripeptide (L-ᵞ-glutamyl-L-cysteinyl-glycine) that serves as an antioxidant in the body and can be coupled with hyaluronic acid for anti-aging purposes. Glutathione, being hydrophilic, encounters challenges in penetrating the stratum corneum barrier to access the deeper epidermal layers; thus, a transfersome delivery mechanism is requisite. This study aimed to examine the synthesis of transfersome containing glutathione and hyaluronic acid using the thin layer hydration method and the dispersion method. The characteristics measured included organoleptic properties, particle size, zeta potential, polydispersity index (PDI), entrapment efficiency, and antioxidant activity assessed via the DPPH method. Particle size and PDI were found to be 124.5 ± 14.11 nm, 0.367± 0.07 for thin layer hydration method and 583.03 ± 32.41 nm, 0.595 ± 0.03 for dispersion method respectively. Entrapment efficiency showed that the thin layer hydration method was greater at 35.65% ± 3.54 compared to the dispersion method at 19.10 % ± 1.13. Antioxidant activity showed the inhibition in thin layer hydration and dispersion method was 42.48% ± 0.84 and 41.23% ± 2.09 respectively. In conclusion, the thin layer hydration method gives more optimal results than the dispersion method.
Co-Authors Adhyatmika Dian Ermawati Gunawan Pamudji Widodo Ilham Kuncahyo, Ilham Khadijah Zai M. Henityo Agung As'adi Martsom Putra Sulung S Langga Mukti, Yusuf Anggoro Nonni Soraya Sambudi Nunung Yuniarti Satibi Teguh Imanto