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All Journal Jurnal Katalisator Riset Informasi Kesehatan Pharmacon: Jurnal Farmasi Indonesia
Teuku Nanda Saifullah Sulaiman
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Agriculture, Biological Sciences & Forestry Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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Formulation of fenofibrate nanocrystals with wet milling method M. Henityo Agung As'adi; Ilham Kuncahyo; Teuku Nanda Saifullah Sulaiman
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.761

Abstract

Background: Fenofibrate is an antihyperlipidemic belonging to BCS class II, practically insoluble in water and has high lipophilicity, so it is proven that the inhibitor of the rate of absorption of fenofibrate from the digestive tract is slow to dissolve. This study aims to increase the solubility of fenofibrate by forming nanocrystals. Method: Formation of nanocrystals using the wet milling method Result: The fenofibrate nanocrystals produced a particle size of 775.966 nm, a zeta potential of -21.302 mV, and a solubility of 5.977 μg/mL. Conclusion : The optimum formula with tween 80 components, grinding speed and grinding time in the manufacture of fenofibrate nanocrystals using the Factorial Design method obtained 0.2% tween 80, grinding speed of 500 rpm and grinding time of 1 hour. The critical parameter test results for the optimum formula obtained a particle size of 775.966 nm, a zeta potential of -21.302 mV and a solubility of 5.977 µg/mL. The DSC test showed that there was a difference in the melting point peaks and a decrease in crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The FTIR test showed no difference in functional groups between pure fenofibrate and fenofibrate nanocrystals. The XRD test showed that there was a difference in peak crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The SEM analysis shows that there are differences in shape and magnification used between pure fenofibrate and fenofibrate nanocrystals.
Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review Imanto, Teguh; Nonni Soraya Sambudi; Khadijah Zai; Teuku Nanda Saifullah Sulaiman
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6986

Abstract

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These systems offer localized, sustained drug release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) and Polycaprolactone (PCL), which ensure controlled drug release while supporting bone regeneration. A systematic search using PRISMA guidelines across ScienceDirect and ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion of bioactive agents such as hydroxyapatite in nanofibers was found to enhance antibacterial properties and accelerate tissue regeneration. The review demonstrates that antibiotic-loaded nanofibers offer a promising, targeted therapeutic alternative to conventional treatments, particularly for osteomyelitis and similar challenging bone infections. Future research directions will focus on optimizing nanofiber compositions and functionalities to better meet clinical needs, ensuring more efficient and personalized management of severe bone infections.
FORMULATION ANTIAGING CREAM MELASTOMA MALABATCHRICUM EXTRACT WITH POLYOXYETHYLENE MONOSTEARATE AND STEARIC ACID Mukti, Yusuf Anggoro; Gunawan Pamudji Widodo; Teuku Nanda Saifullah Sulaiman
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3045

Abstract

Karamunting fruit (Melastoma malabathricum L.) contains flavonoids, triterpenoids and tannins. The purpose of this study was to make anti-aging cream preparations using caramunting fruit extract with a combination of PEG 40 stearic acid and stearic acid to obtain optimum physical quality. Extract with 96% ethanol filter in the form of extracts used for cream preparations using a base of PEG 40 stearic and stearic acid, so that 8 formulas were obtained, then optimized based on the physical quality parameters of viscosity, spreadability, adhesion and pH, then optimization of the formula to determine the formula optimum using the Simplex Lattice Design method. The conclusion obtained based on this research is the optimum combination of PEG 40 stearic and stearic acid in the cream of caramunting fruit extract using the Simplex Lattice Design method, namely PEG 40 Stearate 4.76% and stearic acid 15.74%. The physical quality stability did not change during one month of storage and the cream did not cause irritation. Formula I had a better and almost equal effect on the collagen test while formula V had a better effect on the elasticity test and the moisture test.
Co-Authors Gunawan Pamudji Widodo Ilham Kuncahyo, Ilham Khadijah Zai M. Henityo Agung As'adi Mukti, Yusuf Anggoro Nonni Soraya Sambudi Teguh Imanto