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All Journal Neurona
Arthur Hendrik Philips Mawuntu
Bagian/KSM Neurologi FK Universitas Sam Ratulangi/RSUP Prof. Dr. R.D. Kandou, Manado
Health Professions Medicine & Pharmacology Neuroscience

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FAKTOR-FAKTOR YANG MEMENGARUHI NEUROPATI PERIFER TERKAIT HIV DI MANADO Deivy Cirayow; Arthur Hendrik Philips Mawuntu; Herlyani Khosama
NEURONA Vol 35 No 3 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i3.9

Abstract

FACTORS THAT INFLUENCE HIV ASSOCIATED PERIPHERAL NEUROPATHY IN MANADOABSTRACTIntroduction: There are  several sociodemographic and clinical factors that influence the development of HIV associated peripheral  neuropathy (HIV-PN). Manado has different sociodemographic and clinical characteristics  from other regions. However, the percentage of HIV-PN and its influencing factors are unknown.Aims: To know the percentage of HIV-PN and factors that influence this disorder in Manado.Methods: A crosssectional study conducted in HIV/AIDS clinic R.D. Kandou hospital Manado between November2016–January 2017. Neuropathy evaluation was performed using brief peripheral neuropathy screening (BPNS), neuropathic pain diagnostic questionnaire (DN4), and electroneurography. A Chi-square or Fisher exact test was done to analyze categorical variables, independent T or Mann-Whitney test was done for numerical variables, and linear regression was done in multivariate analysis.Results: 50 subjects were included, most were male (70%), and the mean age was 32.98 (±9.726) years, with HIV- NP percentage was 46%. Age >30 years old, low hemoglobin count, CD4, and low international  HIV dementia scale (IHDS) significantly associated with HIV-NP. Working subjects were 13.6 times more likely to have HIV-PN.Discussion: HIV-PN prevalence was relatively high, influenced by age >30 years old an low hemoglobin, CD4, andIHDS. As a factor, working was escalating the likelihood of NP-HIV by 13.9 times.Keywords: HIV/AIDS, influencing factors, peripheral neuropathyABSTRAKPendahuluan: Neuropati perifer terkait human immunodeficiency virus/HIV (NP-HIV) dapat dipengaruhi oleh beberapa faktor klinis dan sosiodemografis. Manado mempunyai karakteristik yang berbeda dengan daerah lain, namun belum diketahui persentase NP-HIV dan faktor-faktor yang memengaruhinya.Tujuan: Mengetahui persentase NP-HIV dan faktor-faktor yang memengaruhinya di Manado.Metode: Penelitian potong lintang terhadap pasien HIV/AIDS di poliklinik HIV/AIDS RSUP Prof. dr. R.D. Kandou, Manado, pada November 2016–Januari 2017.  Evaluasi neuropati dilakukan menggunakan brief peripheral  neuropathy screening (BPNS), neuropathic pain diagnostic questionnaire (DN4), dan elektroneurografi. Digunakan uji Chi-square atau Fisher exact untuk menganalisis variabel kategorik, uji T independen atau Mann-Whitney untuk variabel numerik, dan regresi linear untuk analisis multivariat.Hasil: Didapatkan 50 subjek yang memenuhi kriteria penelitian dengan mayoritas laki-laki (70%), rerata usia32,98±9,726 tahun, dan mengalami NP-HIV sebanyak 46%. Usia >30 tahun, kadar hemoglobin, jumlah CD4, dan skor international  HIV dementia scale (IHDS) yang rendah berhubungan secara bermakna dengan adanya NP-HIV. Adapun subjek yang bekerja berisiko 13,6 kali lebih besar mengalami NP-HIV.Diskusi: Didapatkan prevalensi NP-HIV yang cukup tinggi dengan dipengaruhi oleh usia >30 tahun serta kadar hemoglobin, CD4, dan skor IHDS yang rendah. Faktor bekerja juga meningkatkan kecenderungan 13,9 kali mengalami NP terkait HIV.Kata kunci: Faktor-faktor yang memengaruhi, HIV/AIDS, neuropati perifer
PEMERIKSAAN UJI KERUTAN KULIT TERSTIMULASI EUTECTIC MIXTURE OF LOCAL ANAESTHETIC (EMLA) PADA POPULASI NORMAL Arthur Hendrik Philips Mawuntu; Yoce Kurniawan; Meilany Feronika Durry; Herlyani Khosama
NEURONA Vol 36 No 2 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i2.60

Abstract

   EUTECTIC MIXTURE OF LOCAL ANAESTHETIC (EMLA) STIMULATED SKIN WRINKLING TEST IN NORMAL POPULATIONABSTRACTIntroduction: Peripheral neuropathy (PN) could reduce life quality among the affected individuals, while early detection is difficult, apparently healthy individuals could also be affected by this disorder. Stimulated skin wrinkling by eutectic mixture of local anaesthetic test (SSW-EMLA) and brief peripheral neuropathy screening (BPNS) are simple non- invasive examination to detect PN.Aims: To find out the percentage of asymptomatic neuropathy in the normal population using BPNS and SSW-EMLA.Methods: A cross-sectional study on a population that is considered as normal who come to R.D. Kandou Hospital Manado consecutively between October 2015 and September 2016. The normal population was based on modified healthy subject criteria by Lauria et al in a study about skin neural fiber morphometry. Brief peripheral neuropathy screening and SSW-EMLA were performed in all subjects. The Chi-square or Fisher exact test were used to assess between-group differences. P-value of 0.05 was considered statistically significance.Results: We enrolled 99 subjects, most of them were male (61.1%) and the median age was 31 years old. Asymptomatic neuropathy was found in 25.2% of the subjects. The highest neuropathy to non-neuropathy ratio was found in the >40 years old group (0,75). Stimulated skin wrinkling by eutectic mixture of local anaesthetic test could detect more cases compared to BPNS (24.2% vs 7.1%) and this finding was statistically significant.Discussion: The percentage of asymptomatic neuropathy in the normal population was 25.2% and mostly detected by SSW-EMLA compared to BPNS significantly.Keywords: Asymptomatic neuropathy, BPNS, normal population, SSW-EMLAABSTRAKPendahuluan: Neuropati perifer dapat menurunkan kualitas hidup penderitanya, namun deteksi dini masih sulit dilakukan, padahal orang-orang yang terlihat sehat juga dapat mengalaminya. Salah satu pemeriksaan non-invasif sederhana yang dapat dilakukan adalah stimulated skin wrinkling by eutectic mixture of local anaesthetic test (SSW-EMLA) selain skrining brief peripheral neuropathy screening (BPNS) yang biasa digunakan.Tujuan: Mengetahui persentase neuropati asimtomatik pada populasi normal menggunakan BPNS dan SSW- EMLA.Metode: Penelitian potong lintang terhadap populasi yang dianggap normal yang berobat di Instalasi Rawat Jalan RSUP Prof. Dr. R.D. Kandou secara konsekutif antara bulan Oktober 2015 sampai September 2016. Kriteria populasi normal berdasarkan modifikasi dari kriteria subjek sehat yang dibuat oleh Lauria dkk dalam penelitian tentang morfometri serabut saraf dermal kulit manusia. Subjek dilakukan pemeriksaan BPNS dan SSW-EMLA, lalu dinilai perbedaan antar kelompok dengan uji Chi-square atau Fisher’s exact. Nilai p=0,05 dijadikan batas kemaknaan statistik.Hasil: Terdapat 99 subjek yang sebagian besar adalah laki-laki (61,1%) dan median usia adalah 31 tahun. Neuropati asimtomatik ditemukan pada 25,2% subjek. Rasio mengalami dan tidak mengalami neuropati tertinggi ditemukan pada kelompok usia >40 tahun (0,75). Uji SSW-EMLA mampu mendeteksi lebih banyak kasus dibanding BPNS (24,2% vs7,1%) secara bermakna.Diskusi: Didapatkan 25,2% subjek neuropati asimtomatik pada populasi normal yang dominan ditemukan dengan uji SSW-EMLA dibandingkan BPNS secara bermakna.Kata kunci: BPNS, neuropati asimtomatik, populasi normal, SSW-EMLA  
MENINJAU KEMBALI GLASGOW COMA SCALE: MASIHKAH RELEVAN? Arthur Hendrik Philips Mawuntu
NEURONA Vol 36 No 3 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i3.80

Abstract

REVISITING THE GLASGOW COMA SCALE: IS IT STILL RELEVANT?ABSTRACTGlasgow Coma Scale (GCS) is the most popular quantitative assesment of consciousness. Its popularity is gained by the simplicity of the assessment making the scale easy to be performed by medical officers from various background. Glasgow Coma Scale was rapidly adopted worldwide since its first publication in 1974. The wide adoption of the scale has affected the improvement of head injury management as well as other neurological conditions. Furthermore, many large scale studies about head injury have used this scale to evaluate degree of severity and prognosis. After more than 40 years, GCS has underwent various critisms and modifications. The last modification was published on 2014. Some cutting edge devices and new evaluation methods have been introduced in the last two decades that, probably, reduced the role of GCS. However, GCS still seems to be relevant in evaluating patients’clinical condition periodically, therefore we need to understand the development of GCS, its relevance in the present, and some modification of GCS.Keywords: Glasgow Coma Scale, history, relevanceABSTRAKGlasgow Coma Scale (GCS) atau Skala Koma Glasgow (SKG) adalah metode penilaian kuantitatif kesadaran yang paling popular. Popularitasnya justru disebabkan oleh kesederhanaan metode penilaiannya, sehingga mudah dikerjakan oleh petugas kesehatan dari berbagai latar belakang. Glasgow Coma Scale diadopsi dengan cepat di seluruh dunia setelah dipublikasikan pertama kali pada tahun 1974. Hal ini berdampak secara luas pada perbaikan manajemen cedera kepala dan penyakit neurologis lain, serta berbagai penelitian. Setelah lebih dari 40 tahun, skala ini melewati berbagai kritik dan modifikasi, yaitu terakhir pada tahun 2014. Berbagai alat pemeriksaan canggih dan metode penilaian baru telah diperke- nalkan dalam dua dekade terakhir sehingga mungkin mengurangi peran GCS. Meskipun demikian, masih digunakan untuk mengevaluasi keadaan klinis pasien secara berkala, sehingga perlu diketahui tentang perjalanan GCS, relevansinya di masa kini, serta beberapa modifikasi SKG.Kata kunci: Relevansi, sejarah, Skala Koma Glasgow  
Co-Authors Deivy Cirayow Herlyani Khosama Meilany Feronika Durry Yoce Kurniawan