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HUBUNGAN LETAK LESI HEMISFER SEREBRAL DAN DERAJAT KLINIS KECEMASAN PADA PENDERITA STROKE ISKEMIK Yelly Marliana Patu,* Audry Devisanty Wuysang,* Nadra Maricar*
NEURONA Vol. 36 No. 1 Desember 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION STROKE IS THE LEADING CAUSE OF DISABILITY AND THE THIRD CAUSE OF DEATH IN THE WORLD THE LESION IN THE RIGHT HEMISPHERE IS MOST OFTEN ASSOCIATED WITH ANXIETY

HUBUNGAN KADAR LIPID DARAH DENGAN DERAJAT KEPARAHAN NEUROPATI DIABETIK PERIFER DI RUMAH SAKIT WAHIDIN SUDIROHUSODO Devina Irawan,* Audry Devisanty Wuysang,* Yudy Goysal*
NEURONA Vol. 37 No. 1 Desember 2019
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION BLOOD LIPID LEVELS PLAY A ROLE IN THE ETIOPATHOGENESIS OF DIABETIC NEUROPATHY AND HAVE A SIGNIFICANTRELATIONSHIP TO THE SEVERITY OF DIABETIC NEUROPATHY IN PATIENTS WITH DIABETES MELLITUS DM

Hubungan Antara Kadar Kalsium Serum Dengan Keberhasilan Fisioterapi Pada Pasien Stroke Iskemik Yulianti Ely; Andi Wardihan Sindrang; Audry Devisanty Wuysang
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 12, No 1 (2021): Januari
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf12104

Calcium plays an important role in nerve conduction, muscle contraction, and blood clotting. This study aims to determine the relationship of serum calcium levels with the success of physiotherapy in ischemic stroke patients. This study used a cross-sectional design with observational analytics, conducted for 3 months with a sample of 33 people. Based on data analysis, there is the influence of calcium on NIHSS scores, Barthel Index scores and MMT scores (P

CONTRIBUTION OF INFLAMMATION PROCESS (hsCRP LEVELS) IN MIGRAINE DURING ICTAL PHASE Audry Devisanty Wuysang
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2225

ABSTRACTIntroduction: C-reactive protein (CRP), an acute phase protein and a marker of inflammation,has been associated with the risk of cardiovascular disease. CRP has also been suggested tobe abnormal among migraineurs, possibly due to repeated vascular inflammation. Methods:This case-control study was conducted in Wahidin Sudirohusodo General Hospital, Makassar,Indonesia, from June 2013 to January 2014. The aim of this study is to investigate the role ofinflammation in the pathophysiology of an ictal and interictal period of migraine. A t otal of 82patients participated in this study [16 males (19.5%) and 66 females (80.5%)]. The age of ictalperiod patients range between 19-57 years old (median 28, mean 29.54 ± 8.92) and interictalperiod patients range between 20-48 years (median 26, 28,90 ± 7,91). Results: This studyshowed mean hs-CRP level was significantly higher in the ictal period compared to interictalperiod of migraine (6.64 vs 1.87 mg/L). hs-CRP >3mg/L (high risk of cardiovascular event) wasmore common in ictal (78.3%) compared to interictal patients (21,7%), while hs-CRP <1mg/L(low risk of cardiovascular event) was more common in interictal (64.9%) compared to ictalperiod patients (35.1%) (OR=6.646). The contribution of hs-CRP to the ictal period of a migrainewas 17.2%. Conclusion: This study reinforces the view that inflammation processplays some roles in the pathophysiology of a migraine, especially in the ictal period.Keywords: hs-CRP, migraine, ictal.

The Effect of Combination of Calcium Supplement and Physical Exercise on Increasing Muscle Strength in Chronic Ischemic Stroke Nurjannah; Audry Devisanty Wuysang; Andi Aryandy; Ashari Bahar; Cahyono Kaelan; Aryadi Arsyad
Babali Nursing Research Vol 4 No 4 (2023): October
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2023.44297

Background: Stroke causes muscle weakness which results in limitations in daily activities such as self-care, eating, walking, etc. Objective: This study aims to evaluate the effect of calcium supplement and physical exercise on increasing muscle strength in chronic ischemic stroke patients. Method: This research used a quasi-experimental pretest-posttest with control group design. This research was conducted at Dadi Makassar Hospital and Haji Hospital from March to May 2023. The sample obtained was 37 subjects based purposive sampling with an unpaired numerical comparative formula for two sample groups. Consisting of 18 people in the treatment group who were given calcium supplements at a dose of 500 mg per day and physical exercise (Both training, Proprioceptive Neuromuscular Facilitation (PNF) and strengthening) and 19 people in the control group who were only given physical exercise. The research was carried out for 6 weeks using a Manual Muscle Testing (MMT) measuring instrument for muscle strength. This research used the Wilcoxon and Mann Whitney test. (α<0.05) Results: There is a significant of increasing lower extremity muscle strength between pretest and posttest in treatment group and control group (p=0.001; p=0.014, p<0.05), There is an increasing of the upper extremity muscle strength between pretest and posttest in treatment group and control group (p=0.001; p=0.025). There is no significant difference of increasing muscle strength in the upper and lower limb between two groups (p=0.051). Conclusion: Calcium supplements and physical exercise were no more significant in increasing muscle strength than physical exercise only in chronic ischemic stroke patients.

HUBUNGAN LETAK LESI HEMISFER SEREBRAL DAN DERAJAT KLINIS KECEMASAN PADA PENDERITA STROKE ISKEMIK Yelly Marliana Patu; Audry Devisanty Wuysang; Nadra Maricar
NEURONA Vol 36 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i1.54

RELATIONSHIP BETWEEN LOCATION OF CEREBRAL HEMISPHERE LESION AND CLINICAL DEGREES OF ANXIETY IN ISCHEMIC STROKE PATIENTSABSTRACTIntroduction: Stroke is the leading cause of disability and the third cause of death in the world. The lesion in the right hemisphere is most often associated with anxiety.Aim: Knowing the relationship between the location of the lesion and the degree of anxiety in patients with acute ischemic post-stroke.Method: Cross-sectional study of 40 ischemic post-stroke patients at Wahidin Sudirohusodo Hospital and network- ing hospitals in January-April 2018. The degree of anxiety was measured by the Hamilton Anxiety Rating Scale (HARS). Chi-square and Mann-Whitney tests were used to analyze the relationship between variables with a p value <0.05 consid- ered significant.Result: There was a significant relationship between the location of the lesion in the hemisphere and the HARS score (p=0.01); and between the location of infarction lesions (cortical and subcortical) with the degree of anxiety in patients with ischemic stroke (p=0.012).Discussion: Moderate-severe anxiety levels occur higher in the lesions in the right hemisphere. The clinical instru- ments used cannot eliminate the element of subjectivity.Keywords: Anxiety in stroke, ischemic stroke, left hemisphere, lesion location, right hemisphereABSTRAKPendahuluan: Stroke merupakan penyebab utama kecacatan dan kematian ketiga terbanyak di dunia. Lokasi lesi di hemisfer kanan merupakan lokasi lesi yang paling sering dikaitkan dengan timbulnya kecemasan.Tujuan: Mengetahui hubungan antara lokasi lesi dan derajat kecemasan pada penderita pascastroke iskemik akut.Metode: Desain potong lintang pada 40 sampel penderita pascastroke iskemik di RS Wahidin Sudirohusodo dan rumah sakit jejaring pada bulan Januari-April 2018. Derajat kecemasan diukur dengan Hamilton Anxiety Rating Scale (HARS). Uji Chi-square dan Mann-Whitney digunakan untuk menganalisis hubungan antar variabel dengan nilai p<0,05 dianggap bermakna.Hasil: Terdapat hubungan yang signifikan antara lokasi lesi di hemisfer dengan skor HARS (p=0,01); dan antara lokasi lesi infark (kortikal dan subkortikal) dengan derajat kecemasan pada penderita stroke iskemik (p=0,012).Diskusi: Derajat kecemasan sedang-berat lebih tinggi terjadi pada lesi di hemisfer kanan. Instrumen klinis yang digunakan tidak dapat menghilangkan unsur subjektifitas.Kata kunci: Cemas pada stroke, hemisfer kanan, hemisfer kiri, letak lesi, stroke iskemik

HUBUNGAN ANTARA KADAR LIPID DARAH DENGAN DERAJAT HERNIASI DISKUS INTERVERTEBRALIS Elsa Ana Purika; Susi Aulina; Audry Devisanty Wuysang; Andi Alfian Zainuddin
NEURONA Vol 36 No 2 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i2.66

THE CORRELATION BETWEEN SERUM LIPID LEVELS WITH THE SEVERITY OF INTER-VERTEBRAL DISC HERNIATIONABSTRACTIntroduction: Inter-vertebral Disc Herniation (IDH) is one of the common causes of low back pain (LBP). High level of blood lipids is a risk factor for atherosclerosis, and responsible as the cause of decreased blood supply to the intervertebral discs which basically has minimal vascularization, thus, it is estimated that there is a relationship between blood lipid levels and IDH.Aim: To identify the correlation between serum lipid levels with the severity of IDH.Methods: Clinical trials with cross sectional designs were carried out on subjects with IDH during April to June 2018 in Dr. Wahidin Sudirohusodo Hospital, Makassar. Serum lipid levels (HDL, LDL, triglyceride and total cholesterol) were examined and the degree of disc herniation (1 to 4) was assessed. Data analyzed using the Spearman correlation test.Results: In this study there were 40 subjects, 15 males and 25 females, with mean age 50.75 (30-62) years old. Most patients were found with degrees of IDH 2 and 3 (total 75%). The Spearman correlation test showed that there was a negative correlation between HDL with degrees of IDH, as well as a positive correlation between LDL and triglycerides with degrees of IDH, but there was no correlation between total cholesterol levels with degrees of IDH.Discussion: The lower the HDL level, the higher the degree of IDH. On the other hand, the higher the level of LDL and triglycerides, the higher the degree of IDH.Keywords: Inter-vertebral disc herniation, low back pain, serum lipid levelsABSTRAKPendahuluan: Herniasi diskus intervertebralis (HDI) merupakan salah satu penyebab nyeri punggung bawah (LBP) yang cukup sering terjadi. Tingginya kadar lipid darah merupakan faktor risiko untuk aterosklerosis, dan bertanggung jawab sebagai penyebab menurunnya suplai darah pada diskus intervertebralis yang pada dasarnya sudah minim vaskularisasi, sehingga diperkirakan terdapat hubungan antara kadar lipid darah dengan penyakit degenerasi diskus intervertebralis.Tujuan: Mengetahui hubungan antara kadar lipid darah dengan derajat herniasi diskus intervertebralis.Metode: Penelitian potong lintang terhadap subjek dengan herniasi diskus intervertebralis yang berobat ke RSUP Dr. Wahidin Sudirohusodo, Makassar, selama bulan April-Juni 2018. Dilakukan penilaian kadar lipid darah (HDL, LDL, trigiliserida, dan kolesterol total) serta derajat herniasi diskus intervertebralis (1 sampai 4) berdasarkan gejala klinis dan gambaran MRI. Analisis data menggunakan uji korelasi Spearman.Hasil: Didapatkan 40 subjek yang terdiri atas 15 orang laki-laki dan 25 orang perempuan dengan rerata usia 50,75 (30–62) tahun. Mayoritas subjek mengalami HDI derajat 2 dan 3 (total 75%). Uji korelasi Spearman menunjukkan adanya korelasi negatif antara kadar HDL dengan derajat HDI, serta korelasi positif antara kadar LDL dan trigliserida dengan derajat HDI, namun tidak terdapat korelasi antara kadar kolesterol total dengan derajat HDI.Diskusi: Semakin rendah kadar HDL, maka semakin berat derajat HDI. Sebaliknya semakin tinggi kadar LDL dan trigliserida, maka semakin berat derajat HDI.Kata kunci: Herniasi diskus intervertebralis, kadar lipid darah, nyeri punggung bawah

HUBUNGAN ANTARA JUMLAH LIMFOSIT TCD4+ DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN TERINFEKSI HIV Rilia Datan Sampepajung; Audry Devisanty Wuysang; Abdul Muis
NEURONA Vol 36 No 3 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i3.72

CORRELATION BETWEEN QUANTITY OF CD4+ T LYMPHOCYTE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH HIV INFECTIONABSTRACTIntroduction: CD4+T lymphocyte is a T-lymphocyte that has CD4 glycoprotein on its surface. The quantity of CD4+ T lymphocyte is associated with cognitive function impairment.Aim: To determine the correlation between the quantity of CD4+ T lymphocyte with the cognitive function impairment in patients infected by human immunodeficiency virus (HIV).Methods: This is a cross-sectional study on HIV patients at Wahidin Sudirohusodo Hospital, Makassar from October to December 2018. Cognitive function was assessed using Montreal Cognitive Assessment of Indonesian version (MoCA-Ina) and all infected HIV patients’ CD4+ T lymphocyte was counted through blood laboratory examination. The data processing used SPSS program.Results: There were 40 subjects with male majority (70%). Most subjects (75%) had low count of CD4+ T lymphocytes (<200cel/µL) and most of them (72.5%) had cognitive function impairment.Discussion: The CD4+T lymphocyte was associated significantly with executive and memory impairment in patients with HIV.Keywords: CD4+ T lymphocyte, cognitive impairment, HIVABSTRAKPendahuluan: Limfosit TCD4+ adalah limfosit T yang memiliki glikoprotein CD4 pada permukaan selnya. Jumlah limfosit TCD4+ telah diketahui berhubungan dengan gangguan fungsi kognitif.Tujuan: Mengetahui hubungan antara jumlah limfosit TCD4+ dengan gangguan fungsi kognitif pada pasien terinfeksi human immunodeficiency virus (HIV).Metode: Penelitian observasional dengan rancangan potong lintang terhadap pasien yang terinfeksi HIV di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Oktober-Desember 2018. Subjek dinilai fungsi kognitif menggunakan Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) dan penghitungan jumlah limfosit TCD4+. Pengolahan data menggunakan program SPSS.Hasil: Terdapat 40 subjek yang mayoritas (70%) laki-laki. Terdapat 75% subjek memiliki kadar limfosit TCD4+ yang rendah (<200sel/µL) yang sebagian besarnya (72,5%) mengalami gangguan fungsi kognitif.Diskusi: Jumlah limfosit TCD4+ memiliki hubungan yang signifikan dengan komponen eksekutif dan memori dari fungsi kognitif pada pasien yang terinfeksi HIV.Kata kunci: Gangguan kognitif, HIV, limfosit TCD4+

HUBUNGAN KADAR LIPID DARAH DENGAN DERAJAT KEPARAHAN NEUROPATI DIABETIK PERIFER DI RUMAH SAKIT WAHIDIN SUDIROHUSODO Devina Irawan; Audry Devisanty Wuysang; Yudy Goysal
NEURONA Vol 37 No 1 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i1.99

CORRELATION BETWEEN BLOOD LIPID LEVELS AND SEVERITY OF DIABETIC PERIPHERAL NEUROPATHY IN WAHIDIN SUDIROHUSODO HOSPITALABSTRACTIntroduction: Blood lipid levels play a role in the etiopathogenesis of diabetic neuropathy and have a significant relationship to the severity of diabetic neuropathy in patients with diabetes mellitus (DM).Aim: To assess the correlation between blood lipid levels and the severity of diabetic peripheral neuropathy (DPN) based on nerve conduction study (NCS).Methods: A cross-sectional study at Wahidin Sudirohusodo General Hospital, Makassar, consecutively from December 2018 to March 2019 on type 2 DM patients with DPN based on screening for diabetic neuropathy symptoms. HbA1C and blood lipid levels were examined, and DPN severity based on NCS was assessed using electromyoneurography (ENMG) with England criteria. One-way ANOVA was used for correlation analysis.Results: There were 56 subjects with an average age of 60.25 years old, the majority was women (51.8%) with DM duration ≥5 years (62.5%), HbA1C levels of patients ≥7% (55.4%), dyslipidemia (76.8%), and experienced severe DPN (55.4%). There was a significant relationship between blood lipid levels and the severity of DPN (p<0.05), especially in subjects with a patient’s HbA1C level <7%.Discussion: High lipid level plays a role in etiopathogenesis of diabetic neuropathy.Keywords: Blood lipid levels, diabetic peripheral neuropathy, HbA1CABSTRAKPendahuluan: Kadar lipid darah berperan dalam etiopatogenesis neuropati diabetik dan memiliki hubungan signifikan terhadap derajat keparahan neuropati diabetik pada pasien diabetes melitus (DM).Tujuan: Menilai hubungan kadar lipid darah dengan derajat keparahan neuropati diabetik perifer (NDP) berdasarkan Nerve Conduction Study (NCS).Metode: Penelitian potong lintang di RSUP Wahidin Sudirohusodo, Makassar, secara konsekutif periode Desember 2018-Maret 2019 terhadap pasien DM tipe 2 yang mengalami NDP berdasarkan skrining diabetic neuropathy symptoms. Dilakukan pemeriksaan kadar HbA1C dan lipid darah, serta penilaian derajat keparahan NDP berdasarkan KHS menggunakan alat elektromioneurografi (ENMG) dengan kriteria England. Analisis hubungan menggunakan uji one-way ANOVA.Hasil: Didapatkan 56 subjek dengan rerata usia 60,25 tahun, mayoritas perempuan (51,8%) dengan durasi DM ≥5 tahun (62,5%), kadar HbA1C pasien ≥7% (55,4%), dalam keadaan dislipidemia (76,8%), dan mengalami NDP berat (55,4%). Terdapat hubungan bermakna antara kadar lipid darah dan derajat keparahan NDP (p<0,05), terutama pada subjek dengan kadar HbA1C pasien <7%.Diskusi: Tingginya kadar lipid darah akan memperberat derajat keparahan NDP.Kata kunci: HbA1C, kadar lipid darah, neuropati diabetik perifer

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